INT119674

Context Info Confidence 0.52 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 8 Disease Relevance 2.84 Pain Relevance 0.99

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2) intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)

Anatomy Link Frequency THP-1 3 monocyte 2 SH-SY5Y 1 B cells 1 Calu-3 1 GLI2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 22 99.96 Inflammation 147 98.60 corticosteroid 7 96.80 cINOD 3 91.08 Abeta 1 89.20 imagery 6 79.44 agonist 72 65.20 addiction 17 51.60 Inflammatory stimuli 3 49.08 antagonist 33 43.20

Disease Link Frequency Relevance Heat Asthma 21 99.84 Neuroblastoma 1 98.64 INFLAMMATION 159 98.60 Mycobacterial Infection 141 98.60 Acute Monocytic Leukemia 2 94.24 Infection 71 91.96 Alzheimer's Dementia 1 88.40 Targeted Disruption 9 86.00 Disease 23 83.20 Disseminated Intravascular Coagulation 3 77.60

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Anatomy

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Speculation

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We compared the neuroprotective activity of S- and R-enantiomers of flurbiprofen and ibuprofen in a standard assay where secretions from activated human THP-1 or microglial cells are toxic to neuroblastoma SH-SY5Y cells.

Localization (secretions) of THP-1 in SH-SY5Y associated with neuroblastoma

1) Confidence 0.52 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15223239 Disease Relevance 0.43 Pain Relevance 0.30

release from monocytic-like cell lines such as THP-1 (22, 28–30), the mechanism of IL-1?

Localization (release) of THP-1 in THP-1

2) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.06 Pain Relevance 0.03

release from LPS-primed THP-1 cells and blood monocytes (22), but the role of P2X7 receptor signaling in human monocyte IL-1?

Localization (release) of THP-1 in monocyte

3) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.07

release from either THP-1 cells or primary human monocytes.

Localization (release) of THP-1 in monocytes

4) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.09 Pain Relevance 0

T helper-2 (TH-2) lymphocytes release cytokines, including IL-4, IL-5 and IL-13, that have a range of actions, including eosinophil activation and immunoglobulin secretion from B cells.

Localization (release) of helper-2 in B cells associated with cytokine

5) Confidence 0.08 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 1.05 Pain Relevance 0.45

Calu-3 and THP-1 secreted the monomeric form of PRXV into the medium (Figure 6A).

Localization (secreted) of THP-1 in THP-1

6) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.24 Pain Relevance 0.07

secretion in human THP-1 cells was inhibited by glutathione and DPI but was not affected in murine BMDMs derived from NOX2-deficient mice (Figures 3B and 3D).

Localization (secretion) of THP-1 in THP-1

7) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.67 Pain Relevance 0

Calu-3 and THP-1 secreted the monomeric form of PRXV into the medium (Figure 6A).

Localization (secreted) of THP-1 in Calu-3

8) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1601951 Disease Relevance 0.24 Pain Relevance 0.07

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