INT1197

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 109
Total Number 115
Disease Relevance 28.29
Pain Relevance 48.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
pituitary 24
plasma 8
melanocyte 8
corticotroph 6
nucleus 4
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 186 100.00 Very High Very High Very High
narcan 146 100.00 Very High Very High Very High
Serotonin 48 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
electroacupuncture 29 100.00 Very High Very High Very High
Glutamate 18 100.00 Very High Very High Very High
anesthesia 12 100.00 Very High Very High Very High
intrathecal 7 100.00 Very High Very High Very High
agonist 304 99.98 Very High Very High Very High
Dopamine 139 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 219 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 8 99.60 Very High Very High Very High
Disease 281 99.54 Very High Very High Very High
Adenoma 38 99.42 Very High Very High Very High
Adrenal Cancer 94 99.40 Very High Very High Very High
Pituitary Cancer 76 99.38 Very High Very High Very High
Pain 114 99.30 Very High Very High Very High
Stress 296 99.28 Very High Very High Very High
Frailty 24 99.28 Very High Very High Very High
Carcinoid 2 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion.
Negative_regulation (suppression) of Localization (release) of ACTH
1) Confidence 0.59 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Dexamethasone produced a significant reversal of exercise-induced pain threshold elevations concomitantly with the suppression of exercise-induced ACTH release.
Negative_regulation (suppression) of Localization (release) of ACTH associated with pain threshold and dexamethasone
2) Confidence 0.59 Published 1990 Journal Brain Res. Section Abstract Doc Link 2168784 Disease Relevance 0.28 Pain Relevance 0.65
Pre-treatment with iv hydrocortisone (200 mg) completely suppressed both ACTH and beta-endorphin release in response to EA without significantly affecting EA anaesthesia in 6 other patients and in a patient with Addison's disease.
Negative_regulation (suppressed) of Neg (without) Localization (release) of beta-endorphin associated with disease and electroacupuncture
3) Confidence 0.59 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6310920 Disease Relevance 0.10 Pain Relevance 0.37
Experimental and human data in young volunteers suggest that tuberoinfundibular dopaminergic systems physiologically inhibit pituitary secretion of beta-endorphin.
Negative_regulation (inhibit) of Localization (secretion) of beta-endorphin in pituitary
4) Confidence 0.59 Published 1986 Journal Clin Neuropharmacol Section Abstract Doc Link 2948639 Disease Relevance 0.23 Pain Relevance 0.11
We conclude that clonidine, by blocking central noradrenergic pathways, which stimulate corticotropin-releasing hormone secretion, inhibits naloxone-induced ACTH secretion.
Negative_regulation (inhibits) of Localization (secretion) of ACTH associated with narcan and clonidine
5) Confidence 0.59 Published 1990 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2160341 Disease Relevance 0 Pain Relevance 0.65
Naloxone-induced ACTH release in man is inhibited by clonidine.
Negative_regulation (inhibited) of Localization (release) of ACTH associated with narcan and clonidine
6) Confidence 0.59 Published 1990 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 2160341 Disease Relevance 0 Pain Relevance 0.76
This inhibition of active ACTH release may result from clonidine blockade of fenfluramine-induced activation of central NNA.
Negative_regulation (inhibition) of Localization (release) of ACTH associated with clonidine
7) Confidence 0.59 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2856056 Disease Relevance 0.15 Pain Relevance 1.15
Inhibition of serotonin-induced ACTH release in man by clonidine.
Negative_regulation (Inhibition) of Localization (release) of ACTH associated with serotonin and clonidine
8) Confidence 0.59 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 2856056 Disease Relevance 0.15 Pain Relevance 1.03
Plasma beta-endorphin levels decreased significantly (p less than 0.005) after intrathecal morphine from 76 +/- 9.7 to 46.3 +/- 9.1 fmol/ml (mean +/- SE), possibly because of decreased pituitary beta-endorphin secretion in response to alleviation of labor pain.
Negative_regulation (decreased) of Localization (secretion) of beta-endorphin in Plasma associated with pain labor, morphine and intrathecal
9) Confidence 0.59 Published 1984 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6087663 Disease Relevance 0.10 Pain Relevance 0.53
Plasma beta-endorphin levels decreased significantly (p less than 0.005) after intrathecal morphine from 76 +/- 9.7 to 46.3 +/- 9.1 fmol/ml (mean +/- SE), possibly because of decreased pituitary beta-endorphin secretion in response to alleviation of labor pain.
Spec (possibly) Negative_regulation (decreased) of Localization (secretion) of beta-endorphin in Plasma associated with pain labor, morphine and intrathecal
10) Confidence 0.59 Published 1984 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6087663 Disease Relevance 0.10 Pain Relevance 0.54
In man the mu-opiate agonist loperamide specifically inhibits ACTH secretion induced by the cholecystokinin-like peptide ceruletide.
Negative_regulation (inhibits) of Localization (secretion) of ACTH associated with narcan, agonist, opiate and cholecystokinin
11) Confidence 0.59 Published 1994 Journal Neuroendocrinology Section Title Doc Link 8090278 Disease Relevance 0.08 Pain Relevance 0.61
In four cultured human corticotropic adenomas, loperamide was not able to reduce basal and CRH-induced ACTH secretion.
Negative_regulation (reduce) of Localization (secretion) of ACTH associated with adenoma
12) Confidence 0.59 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322429 Disease Relevance 0.66 Pain Relevance 0
In humans, the opioid antagonist, naloxone, stimulates the release of CRH, and so of ACTH and cortisol, while alprazolam, an indirect GABAA agonist, blocks naloxone-induced ACTH and cortisol secretion.
Negative_regulation (blocks) of Localization (secretion) of ACTH associated with antagonist, agonist, narcan and opioid
13) Confidence 0.59 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.62
Sodium valproate (SV) inhibits ACTH release in response to CRH, metyrapone and substance P.
Negative_regulation (inhibits) of Localization (release) of ACTH associated with substance p
14) Confidence 0.59 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.61
Estrogen and glucocorticoids decreased, in a dose- and time-dependent manner, the secretion of beta-endorphin from the Ishikawa cells while progesterone and dihydrotestosterone did not have a statistically significant effect.
Negative_regulation (decreased) of Localization (secretion) of beta-endorphin
15) Confidence 0.58 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7978924 Disease Relevance 0 Pain Relevance 0.54
The antiprogestin-antiglucocorticoid RU486 acted as an agonist, i.e., it diminished beta-endorphin secretion possibly via glucocorticoid receptors.
Negative_regulation (diminished) of Localization (secretion) of beta-endorphin associated with agonist
16) Confidence 0.58 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7978924 Disease Relevance 0 Pain Relevance 0.46
Inhibition of naloxone-stimulated adrenocorticotropin release by alprazolam in myotonic dystrophy patients.
Negative_regulation (Inhibition) of Localization (release) of adrenocorticotropin associated with frailty and narcan
17) Confidence 0.58 Published 1998 Journal J. Neuroendocrinol. Section Title Doc Link 9663654 Disease Relevance 1.11 Pain Relevance 0.39
Dexamethasone (5 mg, i.v.) immediately inhibited the secretion of ACTH from the monkey pituitary.
Negative_regulation (inhibited) of Localization (secretion) of ACTH in pituitary associated with dexamethasone
18) Confidence 0.58 Published 1975 Journal J. Endocrinol. Section Abstract Doc Link 173773 Disease Relevance 0 Pain Relevance 0.14
Somatostatin, dexamethasone, bromocriptine, and cyproheptadine in a concentration of 1 microM each inhibited ACTH release by 25 +/- 2%, 35 +/- 2%, 52 +/- 2%, and 61 +/- 4%, respectively, while lysine vasopressin (0.1 microM) and dibutyryl cAMP (5 mM) stimulated ACTH release by 112 +/- 8% and 220 +/- 4%, respectively.
Negative_regulation (inhibited) of Localization (release) of ACTH associated with somatostatin and dexamethasone
19) Confidence 0.58 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6270182 Disease Relevance 0.33 Pain Relevance 0.48
A met-enkephalin analog inhibits adrenocorticotropin secretion by cultured pituitary cells from a patient with Nelson's syndrome.
Negative_regulation (inhibits) of Localization (secretion) of adrenocorticotropin in pituitary associated with syndrome and enkephalin
20) Confidence 0.58 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6270182 Disease Relevance 0.35 Pain Relevance 0.63

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