INT119700

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 88
Total Number 109
Disease Relevance 65.33
Pain Relevance 11.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
skin 7
osteoblast 5
body 4
macrophages 3
chondrocytes 2
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 312 100.00 Very High Very High Very High
Pain 401 99.80 Very High Very High Very High
dexamethasone 103 99.80 Very High Very High Very High
Multiple sclerosis 380 99.46 Very High Very High Very High
aspirin 17 98.00 Very High Very High Very High
Osteoarthritis 158 97.84 Very High Very High Very High
carbamazepine 122 96.44 Very High Very High Very High
antagonist 49 95.60 Very High Very High Very High
backache 43 93.92 High High
Arthritis 175 92.20 High High
Disease Link Frequency Relevance Heat
Pain 705 100.00 Very High Very High Very High
Osteoporosis 649 100.00 Very High Very High Very High
Skin Cancer 277 100.00 Very High Very High Very High
Infection 201 100.00 Very High Very High Very High
Dengue 63 100.00 Very High Very High Very High
Prostate Cancer 744 99.86 Very High Very High Very High
Rickets 352 99.66 Very High Very High Very High
Osteogenic Sarcomas 89 99.64 Very High Very High Very High
Disease 847 99.60 Very High Very High Very High
Sunburn 156 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vitamin D receptor (VDR), expressed in normal and malignant prostate cells, mediates the biological actions of 1,25(OH)2D [9,23–25].
Gene_expression (expressed) of VDR associated with malignant neoplastic disease
1) Confidence 0.75 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.41 Pain Relevance 0
The vitamin D receptor (VDR), expressed in normal and malignant prostate cells, mediates the biological actions of 1,25(OH)2D [9,23–25].
Gene_expression (expressed) of vitamin D receptor associated with malignant neoplastic disease
2) Confidence 0.75 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.41 Pain Relevance 0
Studies of vitamin D receptor gene
Gene_expression (gene) of vitamin D receptor
3) Confidence 0.66 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.24 Pain Relevance 0.03
We found no interactions of vitamin D level or the VDR polymorphisms with the ?
Gene_expression (polymorphisms) of VDR
4) Confidence 0.65 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.46 Pain Relevance 0.05
For VDR polymorphisms, 1,034 patients (and 1,566 control participants) had the FokI genotype data, and 1,010 patients (and 1,432 control participants) had the BsmI genotype data.
Gene_expression (polymorphisms) of VDR
5) Confidence 0.65 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.33 Pain Relevance 0
The common etiological factors of vitamin D deficiency are lack of exposure to sun rays (solar ultraviolet-B exposure to as much of body surface as possible produces vitamin D) and decreased intake of foods rich in vitamin D.
Gene_expression (produces) of vitamin D in body
6) Confidence 0.65 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.74 Pain Relevance 0
Since the affinity of binding of the receptor to the DRE was lower than to a DR3, the CAT activity was also examined after the overexpression of VDR.
Spec (examined) Gene_expression (overexpression) of VDR
7) Confidence 0.65 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
HeLa cells possess endogenous VDR, but do not express DREAM (2,28).
Neg (not) Gene_expression (express) of VDR in HeLa
8) Confidence 0.65 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
The common etiological factors of vitamin D deficiency are lack of exposure to sun rays (solar ultraviolet-B exposure to as much of body surface as possible produces vitamin D) and decreased intake of foods rich in vitamin D.
Gene_expression (produces) of vitamin D in body
9) Confidence 0.65 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.78 Pain Relevance 0.03
These findings are associated with the observations that Dex enhances VDR expression in SCC cells and VDR ligand binding activities in tumor cell extracts and kidneys but decreases that in intestinal mucosa 53.
Gene_expression (expression) of VDR associated with cancer, skin cancer and dexamethasone
10) Confidence 0.62 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.11 Pain Relevance 0.23
Increased expression of VDR protein, VDR transcriptional activity, and the expression of VDR target genes are also observed in the combination treatment group 61.
Gene_expression (expression) of VDR
11) Confidence 0.62 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.52 Pain Relevance 0
Molecular mimicry of naturally phosphorylated human PRL at the major phosphorylation site S179, S179D (PRL), sensitizes relatively vitamin D-insensitive prostate cancer cells DU-145 and PC3 to calcitriol-mediated anti-proliferative effect and apoptosis, which is associated with increased VDR and p21 expression 63.
Gene_expression (expression) of VDR associated with prostate cancer and apoptosis
12) Confidence 0.62 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.51 Pain Relevance 0
Genistein, an isoflavone found in soybeans and a number of plants, in combination with calcitriol, inhibits cell growth in human prostate LNCaP cells, which is dependent on increased expression of p21 and associated with increased VDR expression 60.
Gene_expression (expression) of VDR
13) Confidence 0.62 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.70 Pain Relevance 0
Increased expression of VDR protein, VDR transcriptional activity, and the expression of VDR target genes are also observed in the combination treatment group 61.
Gene_expression (expression) of VDR
14) Confidence 0.62 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.48 Pain Relevance 0
Using real-time PCR (LightCycler), we have compared mRNA expression of Vitamin D receptor (VDR), Vitamin D-25-hydroxylase (25-OHase), 25-hydroxyVitamin D-1alpha-hydroxylase (1alpha-OHase), and 1,25-dihydroxyVitamin D-24-hydroxylase (24-OHase) in a melanoma cell line that responds to antiproliferative effects of Vitamin D (MeWo) with a non-responsive melanoma cell line (SkMel5).
Gene_expression (expression) of Vitamin D receptor in MeWo associated with skin cancer
15) Confidence 0.60 Published 2004 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15225804 Disease Relevance 0.41 Pain Relevance 0
Using real-time PCR (LightCycler), we have compared mRNA expression of Vitamin D receptor (VDR), Vitamin D-25-hydroxylase (25-OHase), 25-hydroxyVitamin D-1alpha-hydroxylase (1alpha-OHase), and 1,25-dihydroxyVitamin D-24-hydroxylase (24-OHase) in a melanoma cell line that responds to antiproliferative effects of Vitamin D (MeWo) with a non-responsive melanoma cell line (SkMel5).
Gene_expression (expression) of VDR in MeWo associated with skin cancer
16) Confidence 0.60 Published 2004 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15225804 Disease Relevance 0.41 Pain Relevance 0
Additionally, modulation of cell proliferation by calpain inhibitors, as well as regulation of mRNA expression of VDR, 1alpha-OHase, and 24-OHase genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR, respectively.
Gene_expression (expression) of VDR associated with skin cancer
17) Confidence 0.60 Published 2004 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15225804 Disease Relevance 0.57 Pain Relevance 0
VDR is expressed in both osteoblasts and chondrocytes, both of which are found in osteophytes, suggesting a role for the vitamin D/VDR complex in the formation or progression of osteophytes, or both.
Gene_expression (expressed) of VDR in chondrocytes associated with osteophyte
18) Confidence 0.59 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.83 Pain Relevance 0.19
How does one explain the absence of clinical osteomalacia in individuals with very low vitamin D levels?
Gene_expression (levels) of vitamin D associated with rickets
19) Confidence 0.56 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.36 Pain Relevance 0.42
Thus paradoxically, vitamin D deficiency may be a disease of the rich!
Gene_expression (deficiency) of vitamin D associated with disease
20) Confidence 0.56 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.05 Pain Relevance 0.13

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