INT119711

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.44
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
retina 2
embryos 1
nucleus accumbens 1
brain 1
brainstem 1
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 285 100.00 Very High Very High Very High
Kinase C 15 99.96 Very High Very High Very High
medulla 1 99.68 Very High Very High Very High
Nucleus accumbens 15 99.36 Very High Very High Very High
Hippocampus 23 99.32 Very High Very High Very High
Dopamine 34 99.16 Very High Very High Very High
fluoxetine 96 98.82 Very High Very High Very High
cocaine 26 98.56 Very High Very High Very High
Raphe 30 97.32 Very High Very High Very High
sSRI 159 96.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 99 99.78 Very High Very High Very High
Autism 10 98.76 Very High Very High Very High
Hypertension 5 97.96 Very High Very High Very High
Depression 128 96.44 Very High Very High Very High
Convulsion 7 92.84 High High
Body Weight Changes 1 90.60 High High
Major Depressive Disorder 1 89.28 High High
Affective Disorder 31 88.00 High High
Adhesions 7 82.28 Quite High
Epilepsy 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, the 7 day period of dietary fluoxetine exposure was effective in selectively reducing cell density in the parietal cortex and increasing serotonin transporter protein content in the nucleus accumbens.
Positive_regulation (increasing) of serotonin transporter protein in nucleus accumbens associated with nucleus accumbens, serotonin and fluoxetine
1) Confidence 0.69 Published 2007 Journal Epilepsy Res. Section Abstract Doc Link 17215106 Disease Relevance 0.81 Pain Relevance 1.00
Together, these results suggest that a low estrogen state increases SERT activity in the hippocampus despite an apparent reduction in SERT density.
Positive_regulation (increases) of SERT in hippocampus associated with hippocampus
2) Confidence 0.61 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298349 Disease Relevance 0.32 Pain Relevance 0.72
This resulted in a significant reduction in the activation of the sert promoter (Figure 4B).
Positive_regulation (activation) of sert
3) Confidence 0.59 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Cocaine conditioned place preference (CPP) is intact in dopamine transporter (DAT) knockout (KO) mice and enhanced in serotonin transporter (SERT) KO mice.
Positive_regulation (enhanced) of serotonin transporter associated with targeted disruption, dopamine, serotonin and cocaine
4) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15226739 Disease Relevance 0.57 Pain Relevance 0.67
These data provide evidence that (a) cocaine increases DAex in PFc independently of DAT and that (b), in the absence of SERT, CPu levels of 5-HT(ex) can be increased by blocking DAT.
Positive_regulation (increased) of SERT in PFc associated with dopamine and cocaine
5) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15226739 Disease Relevance 0.71 Pain Relevance 1.26
Another group which reported overall changes in brain volume in a genetic mouse line that was haploinsufficient for PTEN and SLC6A4, two susceptibility genes for autism which have an indirect influence on serotonergic signaling, reported sex specific changes in the social approach test (Page et al., 2009).
Positive_regulation (haploinsufficient) of SLC6A4 in brain associated with autism
6) Confidence 0.44 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2987632 Disease Relevance 0.58 Pain Relevance 0.03
To study the potential capacity of Zic2 to activate Sert transcription, the 130-bp conserved sequence (putative Sert promoter region) was amplified by PCR, cloned into a luciferase reporter plasmid (pGL3-basic), and used for luciferase assays in 293HEK cells.
Positive_regulation (activate) of Sert
7) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
The ectopic expression of Zic2 in cRGCs leads to a lack-of-refinement phenotype of their axons, a defect that is partially reverted after application of fluoxetine indicating, at least in part, this phenotype is caused by induction of Sert.
Positive_regulation (induction) of Sert associated with fluoxetine
8) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.19
To evaluate the relationship between Zic2 and Sert, we performed double staining, combining immunohistochemistry against Zic2 and in situ hybridization for Sert transcripts, on retinal cryosections from E16.5 mouse embryos.
Positive_regulation (hybridization) of Sert in embryos
9) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.08 Pain Relevance 0.08
VT segments showed an increase of around 3.5-fold in Sert mRNA levels compared with segments from the DN region of the retina (Figure 3B).
Positive_regulation (increase) of Sert in retina
10) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
To determine if Sert is a direct transcriptional target of Zic2, we investigated whether this transcription factor activates Sert regulatory sequences.
Positive_regulation (activates) of Sert
11) Confidence 0.42 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Central retinas co-electroporated with pCAG-Zic2 and pCAG-EGFP (Zic2/EGFP) and collected 24 or 72 h after electroporation showed a significant increase of 2.0-fold and 2.5-fold, respectively, in the levels of Sert mRNA compared with samples electroporated with pCAG-EGFP alone (Figure 3B).
Positive_regulation (increase) of Sert in retinas
12) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
We chose to administer citalopram; although many SSRIs such as fluoxetine and paroxetine have significant pharmacological interactions with targets other than SERT [78]–[80], citalopram (CIT) is extremely selective for SERT [26].
Positive_regulation (selective) of SERT associated with ssri and fluoxetine
13) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728775 Disease Relevance 0 Pain Relevance 0.24
We present evidence for the first time that 5-HT transactivates PDGFRbeta through the 5-HTT in pulmonary artery (PA) SMCs.
Positive_regulation (transactivates) of 5-HTT in pulmonary artery
14) Confidence 0.27 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.29 Pain Relevance 0.12
For example, protein kinase C (PKC) activation can decrease SERT activity (Qian et al 1997; Ramamoorthy et al 1998).
Positive_regulation (activation) of SERT associated with kinase c
15) Confidence 0.21 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.22 Pain Relevance 0.29
For example, dopamine transporter densities are increased in the striatum in both cases [96], but serotonin transporter densities are elevated in the brainstem during the early stage of cocaine abstinence [97], but not in clinical depression [98].
Positive_regulation (elevated) of serotonin transporter in brainstem associated with medulla, dopamine, depression, serotonin and cocaine
16) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.79 Pain Relevance 0.61

General Comments

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