INT119713

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
PFc 2
Slc6a3 (Mus musculus)
Cpu3 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 12 99.84 Very High Very High Very High
Dopamine 11 98.66 Very High Very High Very High
fluoxetine 1 89.60 High High
Nucleus accumbens 4 84.72 Quite High
Serotonin 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 11 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data provide evidence that (a) cocaine increases DAex in PFc independently of DAT and that (b), in the absence of SERT, CPu levels of 5-HT(ex) can be increased by blocking DAT.
Negative_regulation (blocking) of DAT in PFc Positive_regulation (increased) of CPu associated with dopamine and cocaine
1) Confidence 0.39 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15226739 Disease Relevance 0.71 Pain Relevance 1.26

General Comments

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