INT119731

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 3.93
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc18a3)
Anatomy Link Frequency
neurons 3
sympathetic 2
dorsal root ganglion 2
cholinergic neuron 1
adrenergic neurons 1
Slc18a3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 62 99.80 Very High Very High Very High
Spinal cord 87 99.40 Very High Very High Very High
spinal dorsal horn 16 97.36 Very High Very High Very High
Neuropeptide 100 97.20 Very High Very High Very High
Somatostatin 3 97.16 Very High Very High Very High
TRP channel 100 96.52 Very High Very High Very High
Dopamine 14 95.68 Very High Very High Very High
noradrenaline 70 93.60 High High
Enkephalin 1 93.60 High High
imagery 63 92.40 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 989 99.86 Very High Very High Very High
Weight Loss 1 89.92 High High
Disease 10 88.60 High High
Injury 7 85.44 High High
Targeted Disruption 278 83.12 Quite High
Neuropathic Pain 26 81.72 Quite High
Motor Neuron Diseases 14 79.04 Quite High
Low Back Pain 14 65.76 Quite High
Death 99 63.40 Quite High
Paralysis 1 58.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data show that ret is required for the development of cholinergic sympathetic neurons at advanced developmental stages but not for the induction of ChAT and VAChT expression early during embryonic development.
Gene_expression (expression) of VAChT in neurons
1) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.30 Pain Relevance 0
Whether ChAT and VAChT expression is affected remains to be analysed.


Gene_expression (expression) of VAChT
2) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.18 Pain Relevance 0.05
After the ret-independent initial induction of ChAT and VAChT expression in the majority or even all sympathetic neurons, the cholinergic markers are lost in most cells and become expressed at comparatively high levels in a small subset of sympathetic neurons (Fig. 5).
Gene_expression (expression) of VAChT in neurons
3) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.03
In newborn ret mutant animals, expression of ChAT and VAChT is largely undetectable indicating that the downregulation of cholinergic gene expression has occurred but that development of the remaining cholinergic neuron population is disturbed.
Gene_expression (expression) of VAChT in cholinergic neuron
4) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0
Cells showing low levels of expression of VAChT mRNA at this stage, however, are only moderately reduced in mutant mice, similar to the total cell population.
Gene_expression (expression) of VAChT mRNA
5) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.28 Pain Relevance 0
We determined whether the SCCs express ChAT and VAChT, two critical elements for synthesis and packaging of ACh, a potential transmitter.
Spec (whether) Gene_expression (express) of VAChT
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.08 Pain Relevance 0.07
Additionally, the SCCs express choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) for synthesizing and packaging acetylcholine, a potential transmitter.
Gene_expression (express) of VAChT
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912856 Disease Relevance 0.14 Pain Relevance 0.09
There have been reports that dorsal root ganglion (DRG) neurons express several marker molecules for cholinergic neurons, including cholinergic vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) [16-18].
Gene_expression (express) of acetylcholine transporter in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
8) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.60 Pain Relevance 1.28
There have been reports that dorsal root ganglion (DRG) neurons express several marker molecules for cholinergic neurons, including cholinergic vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) [16-18].
Gene_expression (express) of VAChT in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
9) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.60 Pain Relevance 1.28
At E13 and E14, when many STG cells express ChAT and VAChT mRNAs at low levels, no reduction of the cholinergic markers is observed by ISH in mutant mice (Burau et al. 2004).
Gene_expression (express) of VAChT associated with ganglion cysts
10) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.27 Pain Relevance 0
This has been confirmed in newborn ret mutant mice, which almost entirely lose the expression of ChAT and VAChT mRNAs in sympathetic ganglia.
Gene_expression (expression) of VAChT in sympathetic
11) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0
The number of STG cells with strong expression of ChAT and VAChT mRNAs is reduced in mutant animals by more than 80%.
Gene_expression (expression) of VAChT associated with ganglion cysts
12) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.28 Pain Relevance 0.03
After embryonic day 14, most cells lose ChAT and VAChT expression.
Gene_expression (expression) of VAChT
13) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.12
-hydroxylase (DBH), and the enzyme synthesizing acetylcholine, choline acetyltransferase (ChAT), which is coexpressed from the cholinergic gene locus with the vesicular acetylcholine transporter (VAChT).
Gene_expression (coexpressed) of VAChT
14) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.25
An essential aspect of this process is the loss of ChAT and VAChT expression in a large number of sympathetic neurons (Burau et al. 2004).
Gene_expression (expression) of VAChT in neurons
15) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.10
Initiation of cholinergic differentiation occurs during embryonic day 11 when ChAT and VAChT mRNA is first detectable by in situ hybridization.
Gene_expression (detectable) of VAChT mRNA
16) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.08 Pain Relevance 0.11
-hydroxylase (DBH), and the enzyme synthesizing acetylcholine, choline acetyltransferase (ChAT), which is coexpressed from the cholinergic gene locus with the vesicular acetylcholine transporter (VAChT).
Gene_expression (coexpressed) of acetylcholine transporter
17) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.25
Observations on a variety of gene products involved in specific neuronal functions hint at crucial regulatory processes that occur during the third week in mouse embryogenesis and that result in the development of sympathetic and sensory neuron classes differing in molecular equipment and, consequently, function. ret signalling is crucially involved in the expression of the cholinergic markers ChAT and VAChT at this time in sympathetic neurons.
Gene_expression (expression) of VAChT in sympathetic
18) Confidence 0.28 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.06
In addition, expression studies of motor neuron-specific markers, vesicular acetylcholine transporter and the high affinity choline transporter, demonstrated that motor neurons in the lumbar spinal cord were partly spared from degeneration by reduced VGLUT2 expression in Sod1G93A;Vglut2flox/+ mice.
Gene_expression (expression) of acetylcholine transporter in motor neuron associated with spinal cord
19) Confidence 0.10 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.81 Pain Relevance 0.19
Three subpopulations of PG neurons supplying BG could be distinguished: 1) cholinergic neurons [vesicular acetylcholine transporter (VAChT)-positive] which also contained vasoactive intestinal polypeptide (VIP), nitric oxide synthase (NOS), SOM and NPY, 2) adrenergic neurons (TH-positive) which also stained for NPY, GAL or leu5-enkephalin (LEU), and 3) non-adrenergic, non-cholinergic neurons (NANC).
Gene_expression (contained) of vesicular acetylcholine transporter in adrenergic neurons associated with somatostatin and enkephalin
20) Confidence 0.03 Published 2004 Journal Pol J Vet Sci Section Abstract Doc Link 15230545 Disease Relevance 0.25 Pain Relevance 0.41

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