INT119743

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
sensory neurons 2
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 4 99.36 Very High Very High Very High
dorsal root ganglion 3 99.32 Very High Very High Very High
potassium channel 1 98.20 Very High Very High Very High
Pain 7 96.56 Very High Very High Very High
agonist 4 91.36 High High
Inflammatory mediators 2 86.16 High High
IPN 1 83.00 Quite High
Inflammation 3 75.00 Quite High
Root ganglion neuron 3 75.00 Quite High
imagery 1 46.56 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.32 Very High Very High Very High
Nociception 11 97.56 Very High Very High Very High
Pain 6 96.56 Very High Very High Very High
INFLAMMATION 4 85.76 High High
Inflammatory Pain 1 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Fos expression caused by PAR-2 activation was inhibited by ablation of capsaicin-sensitive sensory neurons.
Negative_regulation (inhibited) of Positive_regulation (activation) of PAR-2 in sensory neurons associated with qutenza
1) Confidence 0.43 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232294 Disease Relevance 0.42 Pain Relevance 0.44
We found that activation of PAR-2 in these cells strongly inhibited M-type potassium currents (conducted by Kv7 potassium channels).
Negative_regulation (inhibited) of Positive_regulation (activation) of PAR-2 associated with potassium channel
2) Confidence 0.43 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 1.09 Pain Relevance 0.47
Moreover, protein kinase A does not participate in the inhibition of P2X3 currents caused by PAR2 activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of PAR2
3) Confidence 0.43 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.47 Pain Relevance 0.40

General Comments

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