INT11975

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Context Info
Confidence 0.71
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 4.06
Pain Relevance 6.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
striatum 9
nucleus accumbens 2
caudate-putamen 2
DRG 2
spinal 1
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 10 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
dorsal root ganglion 10 99.82 Very High Very High Very High
Dopamine 33 99.68 Very High Very High Very High
opiate 4 99.54 Very High Very High Very High
Central grey 2 99.52 Very High Very High Very High
projection neuron 6 99.46 Very High Very High Very High
Dorsal horn 3 99.08 Very High Very High Very High
substance P 8 99.04 Very High Very High Very High
Inflammation 5 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 99.82 Very High Very High Very High
Shock 6 99.78 Very High Very High Very High
Urological Neuroanatomy 2 99.52 Very High Very High Very High
INFLAMMATION 5 98.44 Very High Very High Very High
Nociception 11 94.96 High High
Parkinson's Disease 19 92.72 High High
Dyskinesias 16 90.56 High High
Pain 4 70.56 Quite High
Stress 1 56.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the inflammation-induced response of dorsal horn projection neurons and local circuit neurons expressing preprotachykinin (PPT) mRNA using RNA blot analysis and in situ hybridization histochemistry.
Transcription (expressing) of PPT in projection neurons associated with inflammation, dorsal horn and projection neuron
1) Confidence 0.71 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1613548 Disease Relevance 0.42 Pain Relevance 0.57
Expression of the preprotachykinin (PPT) mRNA and of the preproenkephalin (PPE) mRNA in the rat striatum has been assessed by in situ hybridization.
Transcription (Expression) of PPT in striatum
2) Confidence 0.68 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.06 Pain Relevance 0.04
As measured by Northern analysis, PPT and PPE mRNA levels were elevated 50% and 160% respectively in the anterior ventromedial striatum (region included nucleus accumbens).
Transcription (levels) of PPT in nucleus accumbens associated with nucleus accumbens
3) Confidence 0.50 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.16
To determine if increased PPT and PPE mRNA levels represented a transient response to brief 5-HT inhibition, additional experiments were performed to provide continual suppression of 5-HT within the striatum.
Transcription (levels) of PPT in striatum
4) Confidence 0.50 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.20
The changes in mRNA levels for protachykinin and proenkephalin were uniform throughout the caudate-putamen of the rat as determined by in situ hybridization histochemistry.
Transcription (levels) of protachykinin in caudate-putamen
5) Confidence 0.47 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
We have investigated the effect of dopamine receptor blockade on striatal proenkephalin mRNA and protachykinin mRNA by Northern gel analysis and by in situ hybridization histochemistry.
Transcription (mRNA) of protachykinin associated with dopamine receptor
6) Confidence 0.47 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
We have investigated the effect of dopamine receptor blockade on striatal proenkephalin mRNA and protachykinin mRNA by Northern gel analysis and by in situ hybridization histochemistry.
Transcription (mRNA) of protachykinin associated with dopamine receptor
7) Confidence 0.47 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
Treadmill running induced a significant increase in the levels of both PPT (60% increase) and PPE (90% increase) mRNA in the striatum of normal rats.
Transcription (levels) of PPT in striatum
8) Confidence 0.47 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.26
Analysis of hybridization signals in the emulsion autoradiography showed that the lumbar-5 DRG neurons expressing PPTA mRNAs were significantly increased in number and signal intensity on the formalin-injected side.
Transcription (expressing) of PPTA in DRG associated with dorsal root ganglion
9) Confidence 0.45 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.45 Pain Relevance 0.27
Using in situ hybridization histochemistry, we examined the biosynthesis of the preprotachykinin-A (PPTA) mRNAs, which code for substance P (SP) and also a related peptide, substance K (SK), in the rat dorsal root ganglion (DRG).
Spec (examined) Transcription (biosynthesis) of PPTA in DRG associated with ganglion cysts, dorsal root ganglion and substance p
10) Confidence 0.45 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.42 Pain Relevance 0.25
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Transcription (expression) of PPT in STR associated with dopamine
11) Confidence 0.40 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.62
Needle manipulation was also effective in suppressing the mRNA expression of pain-related genes such as Fos, opioid receptor-like 1, tachykinin 1, tachykinin receptor 1, mu-opioid receptor and 5-hydroxytryptamine receptor 2A in the spinal cord.
Transcription (expression) of tachykinin 1 in spinal cord
12) Confidence 0.37 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034454 Disease Relevance 0.07 Pain Relevance 0
The effect of N-methyl-D-aspartate (NMDA) receptor blockade on the expression of preproenkephalin (PPE), preprotachykinin (PPT) and preprodynorphin (PPD) mRNAs in the caudate-putamen and nucleus accumbens was assessed with the non-competitive NMDA receptor antagonist MK-801.
Transcription (expression) of PPT in nucleus accumbens associated with nucleus accumbens and nmda receptor antagonist
13) Confidence 0.31 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.31
Following 6-OHDA, PPT mRNA levels were depressed 60-66% across three subregions of the A-STR and 52-59% across two subregions of the P-STR, while PPE mRNA expression was elevated in both the A-STR (50-62%) and P-STR (55-82%).
Transcription (levels) of PPT in STR
14) Confidence 0.31 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.57
PCA normalized PPT mRNA levels in all regions of the DA-depleted A-STR and P-STR, yet did not alter PPE levels in either dorsal central or medial regions from 6-OHDA alone, but reduced PPE to control levels in the dorsal lateral A-STR.
Transcription (levels) of PPT in STR associated with dopamine
15) Confidence 0.27 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.43
The results of this study indicate that pretreatment with opiate ligands modulates the expression of tachykinin peptide and neurokinin receptor encoding mRNAs in spinal systems following a peripheral chemogenic inflammatory stimulus.
Transcription (expression) of tachykinin in spinal associated with opiate and inflammatory stimuli
16) Confidence 0.25 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.33 Pain Relevance 0.71
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Transcription (levels) of protachykinin associated with dopamine receptor
17) Confidence 0.16 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.33
Using in situ hybridisation histochemistry, we now compare the effects of these drug treatments on striatal preproenkephalin-A (PPE-A) and adenosine A(2a) receptor mRNA expression as markers of the indirect pathway and striatal preprotachykinin (PPT) mRNA and preproenkephalin-B (PPE-B, prodynorphin) mRNA expression as markers of the direct pathway.The equivalent marked losses of specific [3H]mazindol binding in the striatum of all drug treatment groups confirmed the identical nature of the nigral cell loss produced by MPTP treatment.
Transcription (expression) of PPT in striatum associated with parkinson's disease and adenocard
18) Confidence 0.12 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453478 Disease Relevance 0.77 Pain Relevance 0.09
Repeated electroconvulsive shock increases tachykinin and cholecystokinin mRNA expression in ventral periaqueductal gray.
Transcription (expression) of tachykinin in ventral associated with shock, central grey and cholecystokinin
19) Confidence 0.11 Published 1991 Journal Neuroscience Section Title Doc Link 1754069 Disease Relevance 0.56 Pain Relevance 0.30
The effect of N-methyl-D-aspartate (NMDA) receptor blockade on the expression of preproenkephalin (PPE), preprotachykinin (PPT) and preprodynorphin (PPD) mRNAs in the caudate-putamen and nucleus accumbens was assessed with the non-competitive NMDA receptor antagonist MK-801.
Transcription (expression) of PPT in caudate-putamen associated with nucleus accumbens and nmda receptor antagonist
20) Confidence 0.11 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.31

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