INT119753

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 0
Speculated 4
Reported most in Abstract
Documents 7
Total Number 12
Disease Relevance 12.88
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PSCs 7
endothelial cells 2
duct 1
Pscs (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 95 99.96 Very High Very High Very High
Chronic pancreatitis 38 99.22 Very High Very High Very High
Inflammation 12 98.40 Very High Very High Very High
COX2 2 94.36 High High
cytokine 43 93.96 High High
Inflammatory response 1 93.16 High High
alcohol 6 86.68 High High
chemokine 2 79.24 Quite High
COX-2 inhibitor 1 75.20 Quite High
antagonist 12 52.96 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 39 100.00 Very High Very High Very High
Fibrosis 121 99.96 Very High Very High Very High
Pancreatitis 46 99.22 Very High Very High Very High
INFLAMMATION 14 98.40 Very High Very High Very High
Primary Sclerosing Cholangitis 94 98.08 Very High Very High Very High
Pancreatic Cancer 38 96.76 Very High Very High Very High
Alcoholic Pancreatitis 4 96.00 Very High Very High Very High
Bacterial Infection 1 95.36 Very High Very High Very High
Necrosis 3 93.96 High High
Cancer 9 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of hypoxia and conditioned media of hypoxia-treated PSCs on cell functions in PSCs and in human umbilical vein endothelial cells.
Spec (examined) Regulation (effects) of PSCs in endothelial cells associated with hypoxia
1) Confidence 0.45 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.66 Pain Relevance 0.20
Furthermore, in vitro data suggest that ethanol directly acts on PSCs and induces activation [23]: Cultured PSCs respond to ethanol application by increased ?
Regulation (acts) of PSCs
2) Confidence 0.36 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 1.23 Pain Relevance 0.41
To assess the role of fibrosis in pancreatic carcinogenesis, we investigated the effects of pancreatic stellate cells (PSCs), which are largely responsible for pancreatic fibrogenesis, on duct cells, in vitro and in vivo.
Regulation (responsible) of PSCs in duct associated with fibrosis
3) Confidence 0.33 Published 2009 Journal Clin. Gastroenterol. Hepatol. Section Abstract Doc Link 19896093 Disease Relevance 1.21 Pain Relevance 0.18
We examined the effects of hypoxia and conditioned media of hypoxia-treated PSCs on cell functions in PSCs and in human umbilical vein endothelial cells.
Regulation (treated) of PSCs in endothelial cells associated with hypoxia
4) Confidence 0.33 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.63 Pain Relevance 0.20
This study aimed to clarify whether hypoxia affected the cell functions in PSCs.
Spec (whether) Regulation (affected) of PSCs in PSCs associated with hypoxia
5) Confidence 0.33 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.59 Pain Relevance 0.21
Targeting PSCs might be an effective therapeutic approach in chronic pancreatitis.
Regulation (Targeting) of PSCs in PSCs associated with chronic pancreatitis
6) Confidence 0.17 Published 2008 Journal J. Gastroenterol. Section Abstract Doc Link 19012035 Disease Relevance 1.17 Pain Relevance 0.54
Given that activated PSCs are the principle effector cells in pancreatic fibrosis, targeting PSCs might become a promising therapeutic approach.
Regulation (targeting) of PSCs associated with fibrosis
7) Confidence 0.16 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 1.25 Pain Relevance 0.20
Because the activation and cell functions in PSCs are regulated by the dynamic but coordinated activation of intracellular signaling pathways, identification of signaling molecules that play a crucial role in PSCs activation is important for the development of anti-fibrosis therapy.
Regulation (regulated) of PSCs in PSCs associated with fibrosis
8) Confidence 0.15 Published 2009 Journal J. Gastroenterol. Section Abstract Doc Link 19271115 Disease Relevance 0.81 Pain Relevance 0.41
Moreover, we investigated the effect of IS-741 on rat pancreatic stellate cells (PSCs).
Spec (investigated) Regulation (effect) of PSCs in stellate cells
9) Confidence 0.10 Published 2007 Journal Pancreas Section Abstract Doc Link 17414052 Disease Relevance 0.51 Pain Relevance 0.29
Their effects on PSCs can be synergistic, antagonistic or complementary.
Regulation (effects) of PSCs in PSCs
10) Confidence 0.09 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15232519 Disease Relevance 1.06 Pain Relevance 0.86
To examine the role of COX-2 in chronic pancreatitis, we investigated its participation in regulating functions of pancreatic stellate cells (PSCs), using isolated rat PSCs.
Regulation (regulating) of PSCs in PSCs associated with chronic pancreatitis
11) Confidence 0.05 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.42 Pain Relevance 0.32
Assuming a protective role of PAP, we investigated its effects on human PSCs.
Spec (investigated) Regulation (effects) of PSCs in PSCs
12) Confidence 0.04 Published 2009 Journal Pancreatology Section Abstract Doc Link 19077460 Disease Relevance 0.35 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox