INT119769

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 6.57
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
neutrophils 6
leukocytes 3
microglia 3
blood cells 2
dorsal 1
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 406 99.52 Very High Very High Very High
ischemia 73 98.22 Very High Very High Very High
Thalamus 36 97.68 Very High Very High Very High
Pain 17 97.44 Very High Very High Very High
imagery 2 95.60 Very High Very High Very High
Neuropathic pain 56 95.12 Very High Very High Very High
metalloproteinase 20 91.80 High High
projection neuron 6 90.08 High High
Spinal nerve ligature 3 88.28 High High
cytokine 60 87.28 High High
Disease Link Frequency Relevance Heat
Adhesions 420 99.80 Very High Very High Very High
Injury 177 99.78 Very High Very High Very High
INFLAMMATION 465 99.52 Very High Very High Very High
Cv Unclassified Under Development 70 98.22 Very High Very High Very High
Pain 25 97.44 Very High Very High Very High
Neuropathic Pain 81 95.12 Very High Very High Very High
Peripheral Neuropathy 2 87.60 High High
Pathologic Processes 2 85.32 High High
Stab Wounds 12 81.68 Quite High
Hypersensitivity 68 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased immunoreactivity for OX-42 (CR3/CD11b) and GFAP at various brain regions was also observed after the acute and subacute phases of the inflammation, respectively.
CD11b Binding (immunoreactivity) of in brain associated with inflammation
1) Confidence 0.36 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15233755 Disease Relevance 1.01 Pain Relevance 0.80
Immunohistochemistry was performed on sections from untreated and vehicle-treated animals that were exposed to H-I (N = 5 per group) to assess the immune cell response using anti-OX-42, an antibody that binds the CD11b antigen that is expressed on cell surfaces of microglia and macrophages.
CD11b Binding (binds) of in immune cell associated with ischemia
2) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2527306 Disease Relevance 0.57 Pain Relevance 0.26
In ropivacaine-treated CCI rats, the immunoreactivity for CD11b was significantly decreased compared with saline-treated CCI rats (37.8 ± 1.9 a.u. for ropivacaine treatment and 64.2 ± 1.7 a.u. for saline treatment; p < 0.001; n = 4; Figure 2a and 2b).
CD11b Binding (immunoreactivity) of associated with injury
3) Confidence 0.20 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022746 Disease Relevance 0.58 Pain Relevance 0.25
However, in all these rats there was markedly increased immunoreactivity for CD11b or ?
CD11b Binding (immunoreactivity) of
4) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.08 Pain Relevance 0.24
The intact red nucleus contained microglia immunoreactive for CD11b and ?
CD11b Binding (immunoreactive) of in microglia
5) Confidence 0.19 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.32 Pain Relevance 0.14
2 integrins, CD11b and CD11c, the isolectin binding molecule IB4, the microglia specific calcium binding protein IBA-1 and major histocompatibility complex (MHC) class II.
CD11c Binding (binding) of in microglia
6) Confidence 0.19 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.24 Pain Relevance 0.08
2 integrins, CD11b and CD11c, the isolectin binding molecule IB4, the microglia specific calcium binding protein IBA-1 and major histocompatibility complex (MHC) class II.
CD11b Binding (binding) of in microglia
7) Confidence 0.19 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.24 Pain Relevance 0.08
Bilateral dorsal corticospinal tract lesions, combined with retrograde tracing with fluorogold, were performed on 3 rats killed 1 week post operation and 3 rats killed at 2 weeks post operation and reacted for CD11b.
CD11b Binding (reacted) of in dorsal
8) Confidence 0.18 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0 Pain Relevance 0.04
The histograms, in Figure 4A, show the increase in fluorescence intensity over the control responses upon the addition of PAF, as well as the inhibitory effect of feG on PAF enhancement of CD11b antibody binding.
CD11b Binding (binding) of
9) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.14 Pain Relevance 0
The reduction by feG of antibody binding for CD11b and CD16b could be due to several factors which include, preventing the mobilization of granule-stored intracellular molecules, promoting their shedding from the cell surface, or altering antibody binding without affecting the amount of CD11b or CD16b expressed on the cell membrane.
CD11b Binding (binding) of
10) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0
We initially examined if the decrease in binding of CD11b and CD16b antibodies was also observed with intracellular as well as cell surface localized molecules.
CD11b Spec (examined) Binding (binding) of
11) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0
Basal binding of CD11b to peritoneal and blood neutrophils, expressed as MFI, was 1342 ± 102 and 367 ± 46, respectively (Figure 10A).
CD11b Binding (binding) of in neutrophils
12) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.16 Pain Relevance 0.05
Since feG affects CD11b and has no effect on CD11a, CD11c or CD18, it appears that the peptide affects predominately the binding of CD11b antibody rather than promoting a loss of this integrin from the cell.
CD11b Binding (binding) of
13) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.22 Pain Relevance 0.08
The peptide feG reduced basal binding of CD11b to 896 ± 183 and 158 ± 29 for the peritoneal and blood neutrophils, respectively.
CD11b Binding (binding) of in neutrophils
14) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.15 Pain Relevance 0.04
Figure 6 shows that feG reduced binding of CD11b antibody to the cell surface, whereas binding to the internal pool of this marker was not altered.
CD11b Binding (binding) of in internal
15) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0
CD11b and CD16 antibody binding to rat peritoneal and blood cells
CD11b Binding (binding) of in blood cells
16) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.17 Pain Relevance 0.04
This altered antibody binding may reflect reduced affinity of CD11b for its counter and accessory receptors.
CD11b Binding (affinity) of
17) Confidence 0.12 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.21 Pain Relevance 0.10
The binding of CD11b on blood cells was increased 1.8 fold by the antigen, whereas on peritoneal cells the increase was only 1.2 fold.
CD11b Binding (binding) of in blood cells
18) Confidence 0.09 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.14 Pain Relevance 0.04
Incubating the neutrophils with feG alone did not affect binding of CD11b antibody, however if PAF was added to feG incubated cells small, but significant, reductions in CD11b antibody binding of 12%, 17% and 15% occurred with 10-10M, 10-11M and 10-12M feG, respectively (Figure 3A).
CD11b Binding (binding) of in neutrophils
19) Confidence 0.09 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.34 Pain Relevance 0
Effects of feG on binding of CD11b and CD16b antibodies
CD11b Binding (binding) of
20) Confidence 0.09 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0

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