INT119785

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.99
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
neurons 2
Epithelium 2
ganglia 2
forebrain 1
Dorsal root ganglion 1
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 238 100.00 Very High Very High Very High
Dorsal horn 9 99.60 Very High Very High Very High
dorsal root ganglion 7 99.32 Very High Very High Very High
Spinal cord 91 97.92 Very High Very High Very High
GABAergic 162 97.04 Very High Very High Very High
Substantia nigra 73 96.96 Very High Very High Very High
Neuropathic pain 21 94.40 High High
antiallodynic 1 93.84 High High
spinal dorsal horn 2 93.76 High High
Thermal hyperalgesia 2 92.52 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 69 100.00 Very High Very High Very High
Ganglion Cysts 99 99.32 Very High Very High Very High
Neuropathic Pain 27 94.40 High High
Nicotine Addiction 136 94.24 High High
Parkinson's Disease 16 93.96 High High
Frailty 13 93.08 High High
Cold Sores 6 92.60 High High
Hyperalgesia 4 92.52 High High
Herpes Simplex Virus 3 92.40 High High
Cv Unclassified Under Development 72 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the airway epithelial localization of GAD67 expression, bronchial biopsies were obtained by flexible bronchoscopy from the large airway epithelium of 10 healthy nonsmokers and 10 healthy smokers [13].
Localization (localization) of GAD67 in epithelium associated with nicotine addiction
1) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.16 Pain Relevance 0.04
Localization of GAD67 Expression in Human Airway Epithelium
Localization (Localization) of GAD67 in Epithelium
2) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.15 Pain Relevance 0.03
Dorsal root ganglion (DRG) neurons transduced in vitro or in vivo by subcutaneous inoculation produced GAD and released GABA constitutively.
Localization (released) of GAD in Dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, gaba and generalized anxiety disorder
3) Confidence 0.59 Published 2004 Journal Mol. Ther. Section Abstract Doc Link 15233942 Disease Relevance 1.54 Pain Relevance 0.98
We also found that subcutaneous inoculation of rdvGAD67 resulted in enhanced production of GAD and tonical GABA release from transduced DRG neurons.
Localization (release) of GAD in neurons associated with dorsal root ganglion, gaba and generalized anxiety disorder
4) Confidence 0.58 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18180106 Disease Relevance 1.39 Pain Relevance 1.00
Examination of sections stained for HNu, GAD, and GluR2/3 showed a large number of NSC-derived neurons colocalizing both GAD and GluR2/3.
Localization (colocalizing) of GAD in neurons associated with generalized anxiety disorder
5) Confidence 0.30 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1796906 Disease Relevance 0.59 Pain Relevance 0.50
For example, in contrast to the above studies, Liu and colleagues [6,8,38] found GAD immunostaining of the ganglia was not above background but the same group did detect low levels of GAD by real time PCR and Western blotting and also found low level of GABA release into the dorsal horn [6,8,38].
Localization (release) of GAD in ganglia associated with gaba, generalized anxiety disorder and dorsal horn
6) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.75 Pain Relevance 0.66
For example, in contrast to the above studies, Liu and colleagues [6,8,38] found GAD immunostaining of the ganglia was not above background but the same group did detect low levels of GAD by real time PCR and Western blotting and also found low level of GABA release into the dorsal horn [6,8,38].
Localization (release) of GAD in ganglia associated with gaba, generalized anxiety disorder and dorsal horn
7) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.73 Pain Relevance 0.59
Decrease of nigral GAD-expression should result in the reduction of GABA synthesis and release in SN, which may decrease the inhibition on DAergic neurons to play a role in Parkinsonism development after forebrain ischemia.

6.3.

Localization (Decrease) of GAD in forebrain associated with parkinson's disease, gaba, generalized anxiety disorder, ischemia and substantia nigra
8) Confidence 0.07 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.68 Pain Relevance 0.54

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