INT11980

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2008
Negated 3
Speculated 3
Reported most in Abstract
Documents 27
Total Number 32
Disease Relevance 6.17
Pain Relevance 14.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 6
striatum 5
DRG 2
anterior 1
nociceptors 1
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 41 100.00 Very High Very High Very High
Cholecystokinin 12 100.00 Very High Very High Very High
gABA 10 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
Dopamine 50 99.90 Very High Very High Very High
Nucleus accumbens 10 99.88 Very High Very High Very High
Inflammation 13 99.82 Very High Very High Very High
substance P 42 99.80 Very High Very High Very High
Neuropeptide 29 99.80 Very High Very High Very High
Dynorphin 10 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.82 Very High Very High Very High
Hypoxia 10 99.78 Very High Very High Very High
Ganglion Cysts 7 99.60 Very High Very High Very High
Injury 7 99.00 Very High Very High Very High
Hyperalgesia 6 98.06 Very High Very High Very High
Hypertension 3 97.96 Very High Very High Very High
Nociception 7 97.32 Very High Very High Very High
Colitis 2 96.56 Very High Very High Very High
Diverticulitis 1 96.20 Very High Very High Very High
Abdominal Pain 1 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The identification of spinal projection neurons with inflammation-induced increases in PPT mRNA suggests that tachykinin peptides may act as neurotransmitters in nociceptive CNS projection pathways.
Positive_regulation (increases) of PPT mRNA in spinal associated with nociception, neurotransmitter, inflammation and projection neuron
1) Confidence 0.69 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1613548 Disease Relevance 0.58 Pain Relevance 0.60
The corticosterone-induced increase in striatal PPT mRNA was evident after 16 h, but not after 2 h, of corticosterone treatment of ADX animals.
Positive_regulation (increase) of PPT mRNA
2) Confidence 0.69 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.09 Pain Relevance 0.04
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Positive_regulation (increased) of PPT mRNA in neurons associated with injury
3) Confidence 0.68 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.30
These results suggest that the chronic hypoxia causes an increase in lung tachykinin levels which, in turn, enhance the development of pulmonary hypertension.
Positive_regulation (increase) of tachykinin in lung associated with hypoxia and hypertension
4) Confidence 0.67 Published 1995 Journal Respir Physiol Section Abstract Doc Link 7539934 Disease Relevance 0.83 Pain Relevance 0.65
To determine if increased PPT and PPE mRNA levels represented a transient response to brief 5-HT inhibition, additional experiments were performed to provide continual suppression of 5-HT within the striatum.
Spec (determine) Positive_regulation (increased) of PPT in striatum
5) Confidence 0.65 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.19
As measured by Northern analysis, PPT and PPE mRNA levels were elevated 50% and 160% respectively in the anterior ventromedial striatum (region included nucleus accumbens).
Positive_regulation (elevated) of PPT in nucleus accumbens associated with nucleus accumbens
6) Confidence 0.65 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.16
Adjuvant injection increased preprotachykinin (PPT) and calcitonin gene-related peptide (CGRP) messenger RNA (mRNA) after 8 h, whereas somatostatin mRNA expression remained unchanged, in innervating L5 DRG neurons.
Positive_regulation (increased) of PPT in DRG associated with somatostatin and calcitonin gene-related peptide
7) Confidence 0.57 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970189 Disease Relevance 0.35 Pain Relevance 0.56
Prior administration of the 5-HT2A/2C receptor antagonist, ritanserin (1 mg/kg) or the 5-HT2A receptor antagonist, ketanserin (1 mg/kg) completely blocked the DOI-induced increases in striatal PPT mRNA in both lesioned and intact animals.
Positive_regulation (increases) of PPT mRNA associated with antagonist
8) Confidence 0.55 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.67
The increase in the level of PPT mRNA was blocked in rats previously subjected to nigrostriatal deafferentation (i.e., 6-hydroxydopamine lesion) or pretreated with D1-receptor antagonist SCH-23390 (0.1 mg/kg), the D2-receptor antagonist eticlopride (0.5 mg/kg), or the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK-801 (0.1 mg/kg).
Positive_regulation (increase) of PPT mRNA associated with glutamate receptor, antagonist and deafferentation
9) Confidence 0.54 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.30
These results suggest that locomotor activity increases, in a NMDA receptor dependent fashion, the excitatory influence of the corticostriatal glutamatergic system on the two populations of striatal projection neurons, as reflected by increases in the levels of PPT and PPE mRNA.
Positive_regulation (increases) of PPT in projection neurons associated with nmda receptor, eae and projection neuron
10) Confidence 0.54 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.63
Up-regulation of PPE and PPT mRNA was also observed in unlesioned BDNF-injected animals.
Positive_regulation (Up-regulation) of PPT mRNA
11) Confidence 0.53 Published 1994 Journal Neuroreport Section Abstract Doc Link 8025254 Disease Relevance 0 Pain Relevance 0.20
LPS induced significant increases in PPT mRNA and SP levels in vitro and in vivo and an increase in airway reactivity to capsaicin in vivo.
Positive_regulation (increases) of PPT mRNA associated with qutenza and substance p
12) Confidence 0.52 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613715 Disease Relevance 0.07 Pain Relevance 0.41
This suggestion is supported by observations that acute systemic stimulation of 5-HT2A/C receptors with DOI (7 mg/kg single i.p. injection) raised PPT and PPE mRNA levels within anterior dorsolateral (30-60%) and posterior (100-200%) striata, but not within the anterior ventromedial striatum.
Neg (not) Positive_regulation (raised) of PPT in anterior
13) Confidence 0.47 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.15
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Positive_regulation (levels) of PPT mRNA in neurons associated with injury
14) Confidence 0.45 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.30
Analysis of hybridization signals in the emulsion autoradiography showed that the lumbar-5 DRG neurons expressing PPTA mRNAs were significantly increased in number and signal intensity on the formalin-injected side.
Positive_regulation (increased) of PPTA in DRG associated with dorsal root ganglion
15) Confidence 0.39 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.45 Pain Relevance 0.27
Further confirmation of a subset of the genes identified Neuregulin 1 and its high affinity receptor, ErbB4, Tachykinin 1, and Metabotropic glutamate receptor 6 as female specific genes upregulated following L5 nerve root injury.
Positive_regulation (upregulated) of Tachykinin 1 in nerve associated with glutamate receptor and injury
16) Confidence 0.37 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17401154 Disease Relevance 0.38 Pain Relevance 0.59
The results obtained after dopamine depletion or injection of dopamine receptor antagonists suggest that a concomitant increase in dopamine release may enhance PPT mRNA level in striatonigral neurons via D1 receptors, and reduce PPE mRNA level in striatopallidal neurons via D2 receptors.
Spec (may) Positive_regulation (enhance) of PPT mRNA in neurons associated with dopamine, antagonist and dopamine receptor
17) Confidence 0.34 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.61
Treadmill running induced a significant increase in the levels of both PPT (60% increase) and PPE (90% increase) mRNA in the striatum of normal rats.
Positive_regulation (induced) of PPT in striatum
18) Confidence 0.31 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.26
Treadmill running induced a significant increase in the levels of both PPT (60% increase) and PPE (90% increase) mRNA in the striatum of normal rats.
Positive_regulation (increase) of PPT in striatum
19) Confidence 0.31 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.26
Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).
Positive_regulation (increased) of PPT mRNA in ventral associated with nucleus accumbens and neuropeptide
20) Confidence 0.27 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.46

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