INT119827

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 24.21
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN11) cytoplasm (PTPN11)
Anatomy Link Frequency
plasma 3
blood 2
fat 1
B19 1
cochlear 1
PTPN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 30 99.16 Very High Very High Very High
Osteoarthritis 2 96.40 Very High Very High Very High
cytokine 119 93.60 High High
COX-2 inhibitor 1 92.16 High High
cva 22 91.04 High High
headache 31 87.64 High High
cINOD 5 84.80 Quite High
Inflammation 112 47.52 Quite Low
isoflurane 2 9.36 Low Low
anesthesia 17 7.56 Low Low
Disease Link Frequency Relevance Heat
Dengue 1685 100.00 Very High Very High Very High
Infection 826 100.00 Very High Very High Very High
Cancer 13 100.00 Very High Very High Very High
Targeted Disruption 6 99.98 Very High Very High Very High
Influenza Virus Infection 247 99.86 Very High Very High Very High
Fever 264 99.68 Very High Very High Very High
Arthritis 32 99.16 Very High Very High Very High
Dengue Hemorrhagic Fever 177 98.52 Very High Very High Very High
Injury 3 98.28 Very High Very High Very High
Disease 427 98.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NS1 deletion mutant viruses can be successfully produced in IFN deficient Vero cells, which are qualified for human use, reaching titers exceeding 8.0 log10/ml, in turn making the production of such vaccines feasible and comparable to production in eggs.
Gene_expression (produced) of NS1 in eggs
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.45 Pain Relevance 0
In these mice NS1 was expressed in the synovium after arthritis induction.
Gene_expression (expressed) of NS1 in synovium associated with arthritis
2) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 1.49 Pain Relevance 0.23
While transgenic expression of nonstructural protein-1 (NS1) of parvovirus B19 in C57Bl/6 mice did not result in spontaneous arthritis, it did render mice of a resistant genetic background susceptible to collagen-induced arthritis [78].
Gene_expression (expression) of NS1 in B19 associated with targeted disruption and arthritis
3) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 1.57 Pain Relevance 0.23
To confirm whether oil treatment inhibited viral protein but not mRNA production, we also measured mRNA and protein expression levels of another viral protein, NS1, in control and oil treated virus-exposed cells.
Gene_expression (expression) of NS1
4) Confidence 0.75 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0.07 Pain Relevance 0
Following blocking with 3% non fat milk plus 1% BSA, the membranes were incubated anti-IAV NS1 or anti-?
Gene_expression (anti) of NS1 in fat
5) Confidence 0.65 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0.23 Pain Relevance 0
NS1 was designed as a 5?
Gene_expression (designed) of NS1
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694350 Disease Relevance 0.38 Pain Relevance 0.14
The development of a single immunochromatographic assay combining NS1 antigen and DENV IgM antibody detection would provide clinicians with a rapid test for dengue diagnosis sensitive during both the acute and early convalescence phases, between days 0 and 8 after the onset of fever.
Gene_expression (detection) of NS1 associated with convalescence, dengue and fever
7) Confidence 0.64 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.30 Pain Relevance 0
In addition, as observed in Table 3, the sensitivity of NS1 detection rapidly decreases on day five of secondary DENV infection, requiring NS1 detection between days 0 and four for an accurate diagnosis.
Gene_expression (detection) of NS1 associated with infection
8) Confidence 0.64 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.30 Pain Relevance 0
Dengue NS1 Ag STRIP (Bio-Rad Laboratories) is an immunochromatographic test (ICT) for the rapid detection of NS1 antigen.
Gene_expression (detection) of NS1 associated with dengue
9) Confidence 0.64 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 2.02 Pain Relevance 0.19
As suggested by Table 6, the sensitivity of NS1 Ag detection with the three commercial tests would be expected to be higher during primary infection than during secondary infection, and we clearly showed greater sensitivity with the Platelia Dengue NS1 Ag test or the Dengue NS1 Ag STRIP than with the pan-E Dengue Early ELISA.
Gene_expression (detection) of NS1 associated with dengue and infection
10) Confidence 0.64 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.55 Pain Relevance 0
In contrast, NS1 protein expression was significantly decreased by treatment of PR8 with essential oil.
Gene_expression (expression) of NS1
11) Confidence 0.58 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0.14 Pain Relevance 0
We show here a high rate of detection in samples from patients with the rapid immunochromatographic test, Dengue NS1 Ag STRIP — the first ICT test developed for NS1 detection — for all four DENV serotypes.
Gene_expression (detection) of NS1 associated with dengue
12) Confidence 0.58 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 0.78 Pain Relevance 0
We evaluated and compared the performance of the Platelia Dengue NS1 Ag test from Bio-Rad Laboratories with two new commercial tests for the detection of dengue virus NS1 antigen (Ag) in patients with clinically diagnosed DENV infection: Dengue NS1 Ag STRIP, an immunochromatographic assay developed by Bio-Rad Laboratories, and pan-E Dengue Early ELISA, an enzyme-linked immunosorbent assay developed by Panbio (Brisbane, Australia).


Gene_expression (detection) of NS1 associated with dengue and infection
13) Confidence 0.58 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.33 Pain Relevance 0
During in vitro infection, the flavivirus NS1 protein is expressed as an intracellular membrane-associated form essential for viral replication [5],[6] or as a cell surface-associated form that may be involved in signal transduction [7].
Gene_expression (expressed) of NS1 associated with infection
14) Confidence 0.58 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 0.82 Pain Relevance 0
Our findings support the use of diagnostic tools based on the NS1 antigen detection for the diagnosis of acute DENV infection.
Gene_expression (detection) of NS1 associated with infection
15) Confidence 0.58 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2500180 Disease Relevance 1.49 Pain Relevance 0
The development of an ICT for the NS1 detection in whole blood would allow rapid diagnosis of dengue in the field or during medical consultations in health care centers with minimal equipment.
Gene_expression (detection) of NS1 in blood associated with dengue
16) Confidence 0.58 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.01 Pain Relevance 0
However, the severe fatal forms of the disease, such as DHF/DSS, are known to occur between four and six days after fever onset, whereas NS1 detection is optimized for all sera collected during the first five days of the disease.
Gene_expression (detection) of NS1 associated with dengue hemorrhagic fever, fever and disease
17) Confidence 0.58 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.51 Pain Relevance 0
In addition, as observed in Table 3, the sensitivity of NS1 detection rapidly decreases on day five of secondary DENV infection, requiring NS1 detection between days 0 and four for an accurate diagnosis.
Gene_expression (detection) of NS1 associated with infection
18) Confidence 0.56 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.34 Pain Relevance 0
We found that indomethacin and NS-398 treatment significantly upregulated expression of the tumor suppressor gene, PTEN, the MAP kinase phosphatase-3, MKP-3, and the protein tyrosine phosphatase, SHP2.
Gene_expression (expression) of SHP2 associated with cancer
19) Confidence 0.53 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.44 Pain Relevance 0.43
Among the most relevant, we identified a) processes of remodeling and organization of actin (WDR1, CLRN1, FLII), an essential component of the hair-cell bundle; b) formation and maintenance of cilia (ALMS1, USH1G, CC2D2A), the sensory organelles devoted to receive the mechanical stimulus; c) cycling and pH homeostasis in cochlear fluids (ATP6V0A4, KCNQ1, KCNE1L), essentials for the generation and maintenance of the endocochlear potential; d) signal transduction (PTPLA, PTPN11, TBL1X, TIMM8A).
Gene_expression (transduction) of PTPN11 in cochlear
20) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2946934 Disease Relevance 0.35 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox