INT119830

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 20.05
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
Anatomy Link Frequency
macrophages 1
chondrocytes 1
AsPC-1 1
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 98.86 Very High Very High Very High
Osteoarthritis 35 96.36 Very High Very High Very High
ischemia 46 95.28 Very High Very High Very High
Central nervous system 2 91.84 High High
cINOD 6 86.80 High High
COX-2 inhibitor 5 85.40 High High
cerebral cortex 6 83.20 Quite High
Inflammatory marker 8 50.00 Quite Low
Angina 1 38.88 Quite Low
abdominal pain 6 37.60 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 858 100.00 Very High Very High Very High
Death 91 100.00 Very High Very High Very High
Hypoxia 40 99.62 Very High Very High Very High
Atherosclerosis 28 99.60 Very High Very High Very High
Pancreatic Cancer 324 98.60 Very High Very High Very High
Infection 57 98.40 Very High Very High Very High
Mycobacterial Infection 4 98.20 Very High Very High Very High
Cancer 430 98.12 Very High Very High Very High
Rupture 2 97.28 Very High Very High Very High
Stroke 1 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, NS-398 treatment increased expression of apoptotic genes such as BAD, STAT1, and CASP3.
Gene_expression (expression) of BAD associated with apoptosis
1) Confidence 0.50 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.44
EMA, Bcl-2, Ki67, PCNA, Bad, Mcl-1; bcl-x, bak, mdm2, bax, p16, p21, p27, p53 and Cyclin D1 expression were evaluated by the standard avidin-biotin complex method with positive and negative controls as per standard laboratory protocol.
Gene_expression (expression) of Bad
2) Confidence 0.44 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.76 Pain Relevance 0
, Bcl-2, pBAD, BAD and Bak, with monoclonal anti-COX-2 (all purchased from Santa Cruz Biotechnology, Heidelberg, Germany), or anti-?
Gene_expression (with) of BAD
3) Confidence 0.40 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.06 Pain Relevance 0
Bad was overexpressed in 82.6% of cases (19 patients) and Bak was positive in 73.9% (17 patients).
Gene_expression (overexpressed) of Bad
4) Confidence 0.39 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.59 Pain Relevance 0
Immunohistochemical expression of Bad, Mcl-1, bcl-x, bak, mdm2, bax, p16, p21, p53, p27, EMA, Bcl-2, Ki67 and PCNA was correlated with clinico-pathological data including survival outcomes.


Gene_expression (expression) of Bad
5) Confidence 0.34 Published 2010 Journal World J Surg Oncol Section Abstract Doc Link PMC2913917 Disease Relevance 0.86 Pain Relevance 0
In our study, all cases demonstrated diffuse expression of Bax, Bad and Bak proteins in contrast to weak or negative expression of Mcl-1, MDM2 and Bcl-x.
Gene_expression (expression) of Bad
6) Confidence 0.34 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 1.08 Pain Relevance 0
Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions: potential role of STATs, cyclinD1, BAD, and Bcl-XL.
Gene_expression (role) of BAD associated with atherosclerosis and apoptosis
7) Confidence 0.31 Published 2005 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 16005468 Disease Relevance 1.14 Pain Relevance 0
In Bcl-2 family members, the expression of Bcl-2, Bax and Bad after PTL treatment for 48 hours were detected by Western blotting (Fig. 5A).
Gene_expression (expression) of Bad
8) Confidence 0.28 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.58 Pain Relevance 0
No alteration in Bad expression was found after treatment.


Gene_expression (expression) of Bad
9) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2924280 Disease Relevance 0.75 Pain Relevance 0
Western blotting was used to demonstrate Bad, Bcl-2, Bax, caspase-9 and pro-caspase-3 expression.


Gene_expression (expression) of Bad
10) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2924280 Disease Relevance 0.82 Pain Relevance 0
No change was found on Bad
Gene_expression (found) of Bad
11) Confidence 0.24 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.75 Pain Relevance 0
It up-regulates the anti-apoptotic Bcl-2 proteins, Bcl-2, and Bclxl and decreases pro-apoptotic Bax and Bad expression (Bazan 2005).
Gene_expression (expression) of Bad associated with apoptosis
12) Confidence 0.24 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.06 Pain Relevance 0.09
OA chondrocytes incubated in the absence of (control) or in the presence of ET-1 (10 nM) for 72 hours showed that ET-1 did not affect apoptosis (TUNEL reaction; data not shown) or the production of either anti-apoptotic Bcl2 or pro-apoptotic Bad proteins.
Gene_expression (production) of Bad in chondrocytes associated with apoptosis and osteoarthritis
13) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.72 Pain Relevance 0.12
High glucose levels increase expression of the pro-apoptotic Bcl protein Bim (a transcriptional target of FKHR).
Gene_expression (expression) of Bcl protein Bim associated with apoptosis and death
14) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.09 Pain Relevance 0.06
Compared with parental cells and vector cells, clone 2 and pool 1 cells transfected with pcDNA3.1-FRNK showed a decrease in survivin expression and Bad phosphorylation at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 (Fig. 5E).
Gene_expression (expression) of Bad
15) Confidence 0.19 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.62 Pain Relevance 0
LN also caused an increase in the expression of survivin and the phosphorylation of Bad at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 in AsPC-1cells (Fig. 10D).
Gene_expression (expression) of Bad
16) Confidence 0.19 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.38 Pain Relevance 0
It indicated that constitutive pFAK was at least partially responsible for Gem chemoresistance in pancreatic cancer lines and suggested that the mechanisms might be related to survivin expression and pBad (pS136) level.


Gene_expression (expression) of pBad associated with pancreatic cancer
17) Confidence 0.19 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
Compared with parental cells and vector cells, clone 2 and pool 1 cells transfected with pcDNA3.1-FRNK showed a decrease in survivin expression and Bad phosphorylation at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 (Fig. 5E).
Gene_expression (expression) of Bad
18) Confidence 0.15 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.69 Pain Relevance 0
We further found that laminin (LN) induced FAK and Akt phosphorylation in a time-dependent manner, increased the levels of survivin and pBad (pS136) and decreased Gem-induced cytotoxicity and apoptosis in AsPC-1 cells; Specific inhibition of LN-induced FAK phosphorylation by either FAK RNAi or FRNK overexpression suppressed the effects of LN on AsPC-1 cells.
Gene_expression (levels) of pBad in AsPC-1 associated with apoptosis
19) Confidence 0.15 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2806309 Disease Relevance 0.68 Pain Relevance 0
M. tuberculosis infection of epithelial cells results in increased expression of BCL2 and pRb, decreased expression of BAX and BAD, and no change in p53 expression despite a large increase in expression of p53 in infected macrophages.
Gene_expression (expression) of BAD in macrophages associated with mycobacterial infection and infection
20) Confidence 0.13 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.18 Pain Relevance 0

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