INT119831

Context Info Confidence 0.75 First Reported 1999 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 55 Total Number 55 Disease Relevance 40.37 Pain Relevance 8.57

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

Anatomy Link Frequency capsules 2 blood 1 blood vessels 1 colon 1 arms 1 PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat methotrexate 486 100.00 corticosteroid 5 99.28 Arthritis 441 99.04 Inflammation 323 98.22 cINOD 40 98.04 Infliximab 65 97.24 Adalimumab 47 96.50 agonist 95 96.48 Etanercept 38 95.82 cva 13 95.80

Disease Link Frequency Relevance Heat Cancer 1530 100.00 Infection 117 100.00 Microsatellite Instability 333 99.98 Hyperplasia 166 99.96 Colon Cancer 180 99.88 Cholesteatoma 60 99.84 Rheumatoid Arthritis 756 99.62 Lymphatic Filariasis 192 99.62 Lung Cancer 110 99.58 Glioma 18 99.50

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human glioma xenografts treated with PTEN/MMAC gene transfer exhibited...[33]

Gene_expression (transfer) of PTEN associated with glioma

1) Confidence 0.75 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

Nevertheless, co-expression of EGFRvIII and PTEN seem to be predictive factor of response to EGFR inhibitors currently tested in glioblastomas.

Gene_expression (co-expression) of PTEN associated with glioblastoma

2) Confidence 0.75 Published 2009 Journal Bull Cancer Section Abstract Doc Link 19357011 Disease Relevance 0.82 Pain Relevance 0.06

A recent publication by Mellinghoff et al. could identify patients expressing EGFRvIII as well as the tumor suppression protein PTEN showing a greater response to the TKIs [25].

Gene_expression (expressing) of PTEN associated with cancer

3) Confidence 0.75 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1524973 Disease Relevance 0.83 Pain Relevance 0

Human glioma xenografts treated with PTEN/MMAC gene transfer exhibited...[33]

Gene_expression (transfer) of MMAC associated with glioma

4) Confidence 0.75 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

Inactivating mutations and decreased expression (either by LOH or methylation) of PTEN, a tumor suppressor that reverses the action of PI3K, are the most frequently observed aberrations.

Gene_expression (expression) of PTEN associated with cancer

5) Confidence 0.73 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.79 Pain Relevance 0

PAX6 and PTEN expression levels are deemed to be two independent and powerful prognostic markers for the outcome of patients with astrocytic malignant gliomas (24).

Gene_expression (expression) of PTEN associated with glioma

6) Confidence 0.68 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 1.50 Pain Relevance 0.04

We found that indomethacin and NS-398 treatment significantly upregulated expression of the tumor suppressor gene, PTEN, the MAP kinase phosphatase-3, MKP-3, and the protein tyrosine phosphatase, SHP2.

Gene_expression (expression) of PTEN associated with cancer

7) Confidence 0.67 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.42

These results suggest that as a consequence of increased expression of phosphatases such as PTEN and the resulting dephosphorylation of kinases, NSAIDs can negatively regulate the EGF/PDGF pathways in colon cancer cells-a novel mechanism for NSAIDs' chemopreventive actions.

Gene_expression (expression) of PTEN in colon associated with colon cancer and cinod

8) Confidence 0.67 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.50 Pain Relevance 0.46

The discovery of promising specific targets for intervention in the inflammatory arthritis process have included, S1P, IL-7R, Syk, Raf/MEK/ERK 1/2, MK5/PRAK, miRNA, PI3K/PTEN/Akt, NF-?

Gene_expression (/) of PTEN associated with inflammation and arthritis

9) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.99 Pain Relevance 0.63

The discovery of promising specific targets for intervention in the inflammatory arthritis process have included, S1P, IL-7R, Syk, Raf/MEK/ERK 1/2, MK5/PRAK, miRNA, PI3K/PTEN/Akt, NF-?

Gene_expression (/) of PTEN associated with inflammation and arthritis

10) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.99 Pain Relevance 0.63

The prostate cancer cell line LNCaP, lacking both critical enzymes in the negative control of PKB/Akt activation, PTEN and SHIP2, was the most sensitive to these effects, as assessed by analysing the cell cycle profile and expression of cell cycle regulating proteins.

Gene_expression (activation) of PTEN associated with reprotox - general 1

11) Confidence 0.65 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19433066 Disease Relevance 0.60 Pain Relevance 0.42

On the other hand, identical PTEN mutations have been detected in MSI-negative endometrial hyperplasia with coexisting MSI-positive endometrioid endometrial carcinomas.

Neg (negative) Gene_expression (detected) of PTEN associated with microsatellite instability and endometrial cancer

12) Confidence 0.64 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.56 Pain Relevance 0

Interestingly, concordance between MSI status and PTEN mutations has been found; the mutations occur in 60–86% of MSI-positive endometrioid endometrial carcinoma but in only 24–35% of the MSI-negative cases [7–9, 13, 17].

Gene_expression (status) of PTEN associated with microsatellite instability and endometrial cancer

13) Confidence 0.64 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.38 Pain Relevance 0

However, PTEN and KRAS mutations seem to occur earlier, since they were found in simple hyperplasia, partially associated with monoclonality.

Gene_expression (mutations) of PTEN associated with hyperplasia

14) Confidence 0.64 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.59 Pain Relevance 0

In atypical hyperplasia, alterations of PTEN, ?

Gene_expression (alterations) of PTEN associated with hyperplasia

15) Confidence 0.64 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.70 Pain Relevance 0

Thus, some PTEN mutations may precede MSI, and coexistence of both alterations does not necessarily mean a cause-effect relationship [9].

Gene_expression (precede) of PTEN associated with microsatellite instability

16) Confidence 0.64 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.45 Pain Relevance 0

RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].

Gene_expression (promote) of PTEN associated with microsatellite instability and endometrial cancer

17) Confidence 0.64 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.69 Pain Relevance 0

In the patient tumor, PTEN was under-expressed (-109.7 FC in lung relative to compendium; -440.1 FC in lung relative to blood), and we note that PTEN maps to a region of heterozygous loss in the tumor genome.

Gene_expression (expressed) of PTEN in blood associated with cancer

18) Confidence 0.63 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.80 Pain Relevance 0

The drugs were repackaged in look-alike capsules containing either Daflon (500 mg) + DEC (25 mg) or DEC (25 mg).

Gene_expression (containing) of DEC in capsules

19) Confidence 0.58 Published 2003 Journal Filaria J Section Body Doc Link PMC153483 Disease Relevance 0.50 Pain Relevance 0

The drugs were repackaged in look-alike capsules containing either Daflon (500 mg) + DEC (25 mg) or DEC (25 mg).

Gene_expression (containing) of DEC in capsules

20) Confidence 0.58 Published 2003 Journal Filaria J Section Body Doc Link PMC153483 Disease Relevance 0.50 Pain Relevance 0

General Comments

This test has worked.