INT119832

Context Info Confidence 0.49 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 7.12 Pain Relevance 1.19

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

Anatomy Link Frequency blood vessels 2 colon 2 PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 17 98.04 COX-2 inhibitor 2 92.64 antagonist 12 89.84 agonist 60 87.84 cva 2 40.92 cytokine 15 34.12 Inflammation 21 5.00 chemokine 13 5.00 metalloproteinase 6 5.00 imagery 6 5.00

Disease Link Frequency Relevance Heat Cancer 374 100.00 Hyperplasia 23 99.96 Glioma 2 99.50 Ovarian Cancer 100 99.20 Microsatellite Instability 47 98.16 Leukemia 15 98.08 Rheumatoid Arthritis 34 97.44 Malignant Neoplastic Disease 34 96.68 Apoptosis 107 96.60 Lung Cancer 94 96.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human glioma xenografts treated with PTEN/MMAC gene transfer exhibited...[33]

Positive_regulation (transfer) of Gene_expression (transfer) of MMAC associated with glioma

1) Confidence 0.49 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

Human glioma xenografts treated with PTEN/MMAC gene transfer exhibited...[33]

Positive_regulation (transfer) of Gene_expression (transfer) of PTEN associated with glioma

2) Confidence 0.49 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

In atypical hyperplasia, alterations of PTEN, ?

Positive_regulation (alterations) of Gene_expression (alterations) of PTEN associated with hyperplasia

3) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.70 Pain Relevance 0

We found that indomethacin and NS-398 treatment significantly upregulated expression of the tumor suppressor gene, PTEN, the MAP kinase phosphatase-3, MKP-3, and the protein tyrosine phosphatase, SHP2.

Positive_regulation (upregulated) of Gene_expression (expression) of PTEN associated with cancer

4) Confidence 0.44 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.44 Pain Relevance 0.42

These results suggest that as a consequence of increased expression of phosphatases such as PTEN and the resulting dephosphorylation of kinases, NSAIDs can negatively regulate the EGF/PDGF pathways in colon cancer cells-a novel mechanism for NSAIDs' chemopreventive actions.

Positive_regulation (increased) of Gene_expression (expression) of PTEN in colon associated with colon cancer and cinod

5) Confidence 0.44 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.51 Pain Relevance 0.46

ligand, and this is associated with an increase in the expression of PTEN, but

Positive_regulation (increase) of Gene_expression (expression) of PTEN

6) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.71 Pain Relevance 0.07

On the opposite, the presence of a mutated PTEN protein enables Akt phosphorylation, which in turn may phosphorylate I?

Positive_regulation (mutated) of Gene_expression (protein) of PTEN

7) Confidence 0.36 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0

others have shown similar increases in PTEN expression induced by rosiglitazone [44].

Positive_regulation (increases) of Gene_expression (expression) of PTEN

8) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.40 Pain Relevance 0.04

associated with synergistic upregulation of PTEN expression [49].

Positive_regulation (upregulation) of Gene_expression (expression) of PTEN

9) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.11 Pain Relevance 0.12

work of others showing similar increases in PTEN expression induced by

Positive_regulation (induced) of Gene_expression (expression) of PTEN

10) Confidence 0.16 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.41 Pain Relevance 0.04

work of others showing similar increases in PTEN expression induced by

Positive_regulation (increases) of Gene_expression (expression) of PTEN

11) Confidence 0.16 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.41 Pain Relevance 0.04

Overexpression of the PTEN gene by transfection in ovarian cancer cell lines without PTEN mutations leads to decreased VEGF concentrations and a reduced number of new blood vessels.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PTEN gene in blood vessels associated with ovarian cancer

12) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.02 Pain Relevance 0

General Comments

This test has worked.