INT119835

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 7.66
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 9 99.22 Very High Very High Very High
cINOD 5 86.80 High High
COX-2 inhibitor 1 85.80 High High
cerebral cortex 6 83.20 Quite High
ischemia 1 59.36 Quite High
Central nervous system 1 55.92 Quite High
Inflammatory marker 4 50.00 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 75 100.00 Very High Very High Very High
Death 15 100.00 Very High Very High Very High
Hypoxia 39 99.98 Very High Very High Very High
Cancer 61 94.56 High High
Colon Cancer 5 82.36 Quite High
Malignant Neoplastic Disease 9 80.96 Quite High
Obesity 8 64.72 Quite High
Endometrial Cancer 5 63.12 Quite High
Cv General 4 Under Development 1 59.36 Quite High
Stress 7 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, NS-398 treatment increased expression of apoptotic genes such as BAD, STAT1, and CASP3.
Positive_regulation (increased) of Gene_expression (expression) of BAD associated with apoptosis
1) Confidence 0.44 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.44
Bad was overexpressed in 82.6% of cases (19 patients) and Bak was positive in 73.9% (17 patients).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Bad
2) Confidence 0.35 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.59 Pain Relevance 0
High glucose levels increase expression of the pro-apoptotic Bcl protein Bim (a transcriptional target of FKHR).
Positive_regulation (increase) of Gene_expression (expression) of Bcl protein Bim associated with apoptosis and death
3) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.09 Pain Relevance 0.06
Bax and Bad protein expression increased in all the three compartments during hypoxia, while there was no significant change in the expression of anti-apoptotic proteins Bcl-2 and Bcl-xl.
Positive_regulation (increased) of Gene_expression (expression) of Bad associated with hypoxia and apoptosis
4) Confidence 0.05 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.80 Pain Relevance 0.35
In Clonidine pretreated hypoxic group, the hypoxia-induced increased expression of pro-apoptotic proteins Bad and Bax was prevented in all the three fractions.
Positive_regulation (increased) of Gene_expression (expression) of Bad associated with hypoxia, apoptosis and clonidine
5) Confidence 0.04 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.87 Pain Relevance 0.33
In Clonidine pretreated hypoxic group, the hypoxia-induced increased expression of pro-apoptotic proteins Bad and Bax was prevented in all the three fractions.
Positive_regulation (induced) of Gene_expression (expression) of Bad associated with hypoxia, apoptosis and clonidine
6) Confidence 0.04 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.88 Pain Relevance 0.33

General Comments

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