INT119836

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.44
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN11) cytoplasm (PTPN11)
Anatomy Link Frequency
synovium 2
PTPN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 15 100.00 Very High Very High Very High
COX-2 inhibitor 1 92.64 High High
Osteoarthritis 1 87.04 High High
cINOD 5 85.28 High High
Inflammation 35 50.88 Quite High
cytokine 18 31.44 Quite Low
rheumatoid arthritis 22 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 16 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Infection 119 99.96 Very High Very High Very High
Apoptosis 3 95.44 Very High Very High Very High
Hepatitis 2 92.08 High High
Sprains And Strains 7 91.76 High High
Coronary Heart Disease 1 91.20 High High
Targeted Disruption 3 90.60 High High
Dengue 160 90.00 High High
Colon Cancer 4 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these mice NS1 was expressed in the synovium after arthritis induction.
Positive_regulation (induction) of Gene_expression (expressed) of NS1 in synovium associated with arthritis
1) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 1.56 Pain Relevance 0.25
We found that indomethacin and NS-398 treatment significantly upregulated expression of the tumor suppressor gene, PTEN, the MAP kinase phosphatase-3, MKP-3, and the protein tyrosine phosphatase, SHP2.
Positive_regulation (upregulated) of Gene_expression (expression) of SHP2 associated with cancer
2) Confidence 0.47 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.44 Pain Relevance 0.43
In addition, as observed in Table 3, the sensitivity of NS1 detection rapidly decreases on day five of secondary DENV infection, requiring NS1 detection between days 0 and four for an accurate diagnosis.
Positive_regulation (requiring) of Gene_expression (detection) of NS1 associated with infection
3) Confidence 0.42 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.35 Pain Relevance 0
Time to negative NS1 antigenaemia
Positive_regulation (Time) of Gene_expression (antigenaemia) of NS1
4) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919376 Disease Relevance 0 Pain Relevance 0
Briefly, 293 cells were transfected with p125-Luc, pRL-TK, and pCAGGS NS1 or pCAGGS GFP (negative control).
Positive_regulation (transfected) of Gene_expression (transfected) of NS1
5) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2940759 Disease Relevance 0.09 Pain Relevance 0
Briefly, 293 cells were transfected with pISRE-Luc, pRL-TK, and pCAGGS NS1 or pCAGGS GFP (negative control).
Positive_regulation (transfected) of Neg (negative) Gene_expression (transfected) of NS1
6) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2940759 Disease Relevance 0 Pain Relevance 0

General Comments

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