INT119837

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.66
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
macrophages 2
epithelial cells 2
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 21 99.64 Very High Very High Very High
cytokine 116 99.56 Very High Very High Very High
chemokine 27 99.16 Very High Very High Very High
rheumatoid arthritis 211 97.30 Very High Very High Very High
Leflunomide 15 94.64 High High
cINOD 15 87.36 High High
Inflammation 139 85.84 High High
COX-2 inhibitor 1 85.80 High High
Sicca syndrome 10 75.12 Quite High
Infliximab 13 73.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 26 100.00 Very High Very High Very High
Asthma 316 99.84 Very High Very High Very High
Rheumatoid Arthritis 256 97.30 Very High Very High Very High
Cancer 10 94.56 High High
Shock 1 90.36 High High
Injury 6 88.08 High High
Infection 9 86.68 High High
INFLAMMATION 148 85.84 High High
Colon Cancer 4 82.36 Quite High
Alagille Syndrome 1 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas this finding suggested that TNF displays counteracting effects on IFN response activity, others have reported that TNF initiates an IRF1-dependent autocrine loop leading to sustained expression of STAT1-dependent type I IFN response genes [32].
Positive_regulation (leading) of Gene_expression (expression) of STAT1
1) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.32 Pain Relevance 0.26
However, an analysis of the differential gene expression shows that the present RA group is generally characterized by an expression profile highly compatible with previous gene expression studies [39], including the overexpression of several transcription factors (for example, FOS, FOSB, JUN, and STAT1 [10-12]), cytokines/chemokines (for example, IL2, IL4, CCL23, and CCL25 [40]), signal transduction molecules (for example, MAPK9, MAP3K2, PTPN7, and AKT2 [41,42]), cell cycle regulators (for example, CDC12, CCNB2, and CCNE2 [43]), and heat shock proteins (DNAJ molecules; [44]; data not shown), indicating that the present RA cohort is representative for RA patients in general.
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 associated with chemokine, shock, rheumatoid arthritis and cytokine
2) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.16 Pain Relevance 0.57
Additionally, NS-398 treatment increased expression of apoptotic genes such as BAD, STAT1, and CASP3.
Positive_regulation (increased) of Gene_expression (expression) of STAT1 associated with apoptosis
3) Confidence 0.40 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.44
Similarly, immunolabeling studies of DRGs from FIV-infected animals showed that macrophages were the principal sources of STAT-1 and iNOS protein production.
Positive_regulation (sources) of Gene_expression (sources) of STAT-1 in macrophages
4) Confidence 0.35 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.29 Pain Relevance 0.09
MTX therapy reduced p-STAT1 MFI values in CD20+ cells (p?
Positive_regulation (-) of Gene_expression (values) of STAT1 associated with methotrexate
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.24
STAT1 expression and activation is elevated in asthmatic bronchial epithelial cells in some, but not all [117], studies [118].
Positive_regulation (elevated) of Gene_expression (expression) of STAT1 in epithelial cells associated with asthma
6) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.13

General Comments

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