INT119839

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 8.36
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
macrophages 2
intestinal cells 1
epithelial cells 1
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 35 99.62 Very High Very High Very High
cytokine 193 99.56 Very High Very High Very High
chemokine 45 99.16 Very High Very High Very High
rheumatoid arthritis 289 97.30 Very High Very High Very High
metalloproteinase 9 95.00 High High
Leflunomide 30 94.64 High High
cINOD 27 87.36 High High
Inflammation 256 86.64 High High
COX-2 inhibitor 1 85.40 High High
agonist 107 81.24 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 55 100.00 Very High Very High Very High
Asthma 316 98.76 Very High Very High Very High
Repression 12 97.42 Very High Very High Very High
Rheumatoid Arthritis 379 97.30 Very High Very High Very High
Hypoxia 6 94.88 High High
Stress 36 94.72 High High
Cancer 94 94.16 High High
Shock 3 90.36 High High
Injury 44 90.32 High High
Adenocarcinoma 42 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas this finding suggested that TNF displays counteracting effects on IFN response activity, others have reported that TNF initiates an IRF1-dependent autocrine loop leading to sustained expression of STAT1-dependent type I IFN response genes [32].
Gene_expression (expression) of STAT1
1) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.31 Pain Relevance 0.26
However, an analysis of the differential gene expression shows that the present RA group is generally characterized by an expression profile highly compatible with previous gene expression studies [39], including the overexpression of several transcription factors (for example, FOS, FOSB, JUN, and STAT1 [10-12]), cytokines/chemokines (for example, IL2, IL4, CCL23, and CCL25 [40]), signal transduction molecules (for example, MAPK9, MAP3K2, PTPN7, and AKT2 [41,42]), cell cycle regulators (for example, CDC12, CCNB2, and CCNE2 [43]), and heat shock proteins (DNAJ molecules; [44]; data not shown), indicating that the present RA cohort is representative for RA patients in general.
Gene_expression (overexpression) of STAT1 associated with chemokine, shock, rheumatoid arthritis and cytokine
2) Confidence 0.68 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.16 Pain Relevance 0.57
, Ras/MAPK, Src kinase and Jak/Stat kinase pathways.
Gene_expression (kinase) of Stat
3) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.55 Pain Relevance 0
Additionally, NS-398 treatment increased expression of apoptotic genes such as BAD, STAT1, and CASP3.
Gene_expression (expression) of STAT1 associated with apoptosis
4) Confidence 0.62 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15240129 Disease Relevance 0.43 Pain Relevance 0.44
Here, we identify STAT1 and HIF-1?
Gene_expression (identify) of STAT1
5) Confidence 0.58 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0.71 Pain Relevance 0.16
Similarly, immunolabeling studies of DRGs from FIV-infected animals showed that macrophages were the principal sources of STAT-1 and iNOS protein production.
Gene_expression (sources) of STAT-1 in macrophages
6) Confidence 0.54 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.29 Pain Relevance 0.09
In contrast, we demonstrated that transcriptional inhibition of COX-2 by IFNbeta or IFNgamma occurs in cells with silenced signal transducer and activator of transcription 1 (STAT1) expression and that IFNs retained the ability to inhibit COX-2 transcription in cells with activated RasV12, in which IFNgamma failed to induce STAT1.
Gene_expression (expression) of STAT1
7) Confidence 0.50 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.38 Pain Relevance 0.08
To determine whether there is a general differential requirement for STAT1 in gene activation and gene repression in response to IFNgamma in intestinal cells, we performed genome-wide analysis of IFNgamma target genes in an IEC line in which STAT1 expression was silenced by small interfering RNA.
Gene_expression (expression) of STAT1 in intestinal cells associated with repression
8) Confidence 0.50 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.49 Pain Relevance 0.05
In contrast, we demonstrated that transcriptional inhibition of COX-2 by IFNbeta or IFNgamma occurs in cells with silenced signal transducer and activator of transcription 1 (STAT1) expression and that IFNs retained the ability to inhibit COX-2 transcription in cells with activated RasV12, in which IFNgamma failed to induce STAT1.
Gene_expression (expression) of signal transducer and activator of transcription 1
9) Confidence 0.50 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.38 Pain Relevance 0.08
Similarly, immunolabeling studies of DRGs from FIV-infected animals showed that macrophages were the principal sources of STAT-1 and iNOS protein production.
Gene_expression (production) of STAT-1 in macrophages
10) Confidence 0.42 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.29 Pain Relevance 0.09
IL18, OAS genes) or directly involved in IFN signaling (JAK/STAT), STAT1 and OAS1, OAS2, OAS3 and MxA best distinguished the two phenotypes.


Gene_expression (signaling) of STAT1
11) Confidence 0.36 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.35 Pain Relevance 0
MTX therapy reduced p-STAT1 MFI values in CD20+ cells (p?
Gene_expression (values) of STAT1 associated with methotrexate
12) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.24
Our analysis revealed significant reductions in the phosphorylation of AKT and H3 in the PBMC CD4+ cells (Figure S9) but no change in the reduction in p-STAT1 observed in the CD20+ cells.
Gene_expression (observed) of STAT1
13) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.17
STAT1 expression and activation is elevated in asthmatic bronchial epithelial cells in some, but not all [117], studies [118].
Gene_expression (expression) of STAT1 in epithelial cells associated with asthma
14) Confidence 0.26 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.47 Pain Relevance 0.13
IRFs and STAT1
Gene_expression (IRFs) of STAT1
15) Confidence 0.21 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.21 Pain Relevance 0.20
B binding activity although it decreased STAT-1 expression and enhanced expression and binding activity of the AP-1 proteins
Gene_expression (expression) of STAT-1
16) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0 Pain Relevance 0.14
Measured fractions of Specificity protein 1 (Sp1), Signal Transducer and Activator of Transcription (STAT1 and STAT3) and Retinoic Acid Receptor gamma (RAR?)
Gene_expression (fractions) of Signal Transducer and Activator
17) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.36 Pain Relevance 0

General Comments

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