INT11984

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Context Info
Confidence 0.54
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.12
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 1
bone marrow 1
IGHA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 6 99.98 Very High Very High Very High
spinal inflammation 10 99.64 Very High Very High Very High
abdominal pain 3 98.26 Very High Very High Very High
rheumatoid arthritis 5 94.12 High High
Bile 2 94.08 High High
Inflammation 9 72.92 Quite High
imagery 11 42.96 Quite Low
Electroencephalography 6 11.12 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
backache 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 18 99.64 Very High Very High Very High
Cancer 85 99.48 Very High Very High Very High
Eosinophilia 1 98.84 Very High Very High Very High
Abdominal Pain 3 98.26 Very High Very High Very High
Enteritis 1 97.66 Very High Very High Very High
Rhinitis 1 97.46 Very High Very High Very High
Lymphocytosis 12 97.10 Very High Very High Very High
Infection 19 96.58 Very High Very High Very High
Togavirus Infection 123 95.84 Very High Very High Very High
Malignant Neoplastic Disease 11 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum levels of IgA, IgA1, and IgA2 rheumatoid factors (RF) were demonstrated by enzyme-linked immunosorbent assay in 69%, 73%, and 36%, respectively, of 100 patients with rheumatoid arthritis (RA), whereas fewer than 5% of 100 healthy donor sera contained elevated levels of these RFs.
Gene_expression (levels) of IgA1 associated with rheumatoid arthritis
1) Confidence 0.54 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.59 Pain Relevance 0.19
In bone marrow cultures of patients with AS and controls the production of IgA, IgA1 and IgA2 were in the same range as were the relative numbers of bone marrow cells containing IgA and IgA subclasses.
Gene_expression (production) of IgA1 in bone marrow associated with spinal inflammation
2) Confidence 0.20 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1613704 Disease Relevance 0.74 Pain Relevance 0.73
On the other hand, ELISA detecting IgG4 showed the highest specificity (95%), followed by IgG2 (85%) and the least specific test was obtained with detection of IgG (70%) and IgG1 (65%).
Gene_expression (detection) of IgG1
3) Confidence 0.09 Published 2004 Journal J Egypt Soc Parasitol Section Abstract Doc Link 15587312 Disease Relevance 0.61 Pain Relevance 0.11
Olympic game rings All patients had positive IgG4 levels, 55 cases were positive for specific total IgG and IgG1, whereas, only 24 cases had positive IgG2 levels (26.6%).
Gene_expression (positive) of IgG1
4) Confidence 0.09 Published 2004 Journal J Egypt Soc Parasitol Section Abstract Doc Link 15587312 Disease Relevance 0.69 Pain Relevance 0.13
, MMP3, SPON2, PRSS2, CCL3, TMEPAI/PMEPAI, SIX3, MFNG, SOSTDC1, SGNE1, SST, IGHA1, AKR1B10, FCGBP, ATP4B, NCAPH2) were shown to be differentially expressed between the tumours and the paired normal, for the first time.
Gene_expression (expressed) of IGHA1 associated with cancer
5) Confidence 0.09 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC3004887 Disease Relevance 0.91 Pain Relevance 0
All IgG1 controls were negative.
Gene_expression (negative) of IgG1
6) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.07 Pain Relevance 0
It is possible that the CSF lymphocytosis might partly represent an influx of antigen-specific T and B cells (data on lymphocyte subsets is unfortunately not available); the intrathecal synthesis of NMDAR IgG1 antibodies (Tuzun et al., 2009) is likely to require antigen-specific T cell help.
Gene_expression (synthesis) of IgG1 in B cells associated with lymphocytosis and intrathecal
7) Confidence 0.01 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0.64 Pain Relevance 0.09
F5 Fab was expressed as a complete IgG1 molecule, F5 native (n) IgG.
Gene_expression (expressed) of IgG1
8) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2903468 Disease Relevance 0.88 Pain Relevance 0
Twenty sera from patients with suspected enteric infection with A. caninum (manifested as eosinophilic enteritis or unexplained abdominal pain with peripheral eosinophilia) were tested; 16 had total IgG antibodies to Ac68, while IgG1, IgG2, IgG3, and IgG4 responses were found in 11, 10, 9, and 12 of these sera, respectively.
Gene_expression (found) of IgG1 associated with rhinitis, abdominal pain, enteritis, eosinophilia and infection
9) Confidence 0.01 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.98 Pain Relevance 0.10

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