INT119855

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 3.15
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gabbr1) plasma membrane (Gabbr1) transcription factor binding (Gabbr1)
cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Anatomy Link Frequency
neurons 2
brain 2
neuronal 1
proximal 1
extracellular matrix 1
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 140 100.00 Very High Very High Very High
GABAergic 75 97.60 Very High Very High Very High
Pain 26 94.56 High High
Lasting pain 4 90.24 High High
antagonist 51 87.40 High High
agonist 131 86.76 High High
Hyperalgesia 7 84.20 Quite High
adenocard 224 82.84 Quite High
gABA 324 82.20 Quite High
antinociception 2 78.24 Quite High
Disease Link Frequency Relevance Heat
Nociception 48 99.52 Very High Very High Very High
Pain 31 94.56 High High
Generalized Anxiety Disorder 40 88.80 High High
Cognitive Disorder 36 86.40 High High
Hyperalgesia 10 84.20 Quite High
Convulsion 2 83.64 Quite High
Neurological Disease 14 80.08 Quite High
Adhesions 14 73.92 Quite High
Epilepsy 16 64.92 Quite High
Depression 16 64.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that secreted GABAB1 isoforms like
GABAB1j could, in principle, adjust the level of presynaptic
inhibition at glutamatergic terminals. 
Localization (secreted) of GABAB1j
1) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.05 Pain Relevance 0.23
Here, we identified a
novel secreted GABAB1 isoform containing the SDs and addressed
whether such soluble isoforms have the potential to block neuronal
GABAB receptor functions in a dominant-negative manner.
Localization (secreted) of GABAB1 in neuronal
2) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.05 Pain Relevance 0
Our data show that secreted GABAB1 isoforms like
GABAB1j could, in principle, adjust the level of presynaptic
inhibition at glutamatergic terminals. 
Localization (secreted) of GABAB1
3) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.05 Pain Relevance 0.23
It therefore will be interesting to
address whether the production of the various secreted GABAB1
isoforms is regulated in response to physiological stimuli. 
Localization (secreted) of GABAB1
4) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.07 Pain Relevance 0.15
A protein binding to the
first SD of GABAB1a is the extracellular matrix protein fibulin-2,
but whether it mediates GABAB receptor localization is unknown
(19).
Localization (localization) of GABAB in extracellular matrix
5) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.07 Pain Relevance 0
The
GABAB1a and GABAB1b isoforms constitute two
independently regulated receptor subtypes, GABAB(1a,2) and
GABAB(1b,2), whereas the functional role of several secreted
GABAB1 isoforms remains unclear
(1,
14-17).

Localization (secreted) of GABAB1
6) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.32 Pain Relevance 0.10
We therefore asked
whether the SDs of secreted GABAB1 isoforms could act similarly and
scavenge a putative extracellular binding partner of the membrane-bound
GABAB1a subunit. 
Localization (secreted) of GABAB1
7) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.21
Furthermore, in the absence of GABAB(2), the GABAB(1) protein relocates from distal neuronal sites to the soma and proximal dendrites.
Localization (relocates) of GABAB in soma
8) Confidence 0.74 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240800 Disease Relevance 0.25 Pain Relevance 0.15
The
GABAB1a and GABAB1b isoforms constitute two
independently regulated receptor subtypes, GABAB(1a,2) and
GABAB(1b,2), whereas the functional role of several secreted
GABAB1 isoforms remains unclear
(1,
14-17).

Localization (secreted) of GABAB
9) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.33 Pain Relevance 0.10
Soluble SD protein,
when added at nanomolar concentrations to dissociated hippocampal neurons or
to acute hippocampal slices, impairs the inhibitory effect of GABAB
heteroreceptors on evoked and spontaneous glutamate release. 
Localization (release) of GABAB in neurons associated with glutamate
10) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0.07 Pain Relevance 0.15
The
GABAB1a and GABAB1b isoforms constitute two
independently regulated receptor subtypes, GABAB(1a,2) and
GABAB(1b,2), whereas the functional role of several secreted
GABAB1 isoforms remains unclear
(1,
14-17).

Localization (secreted) of GABAB
11) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.33 Pain Relevance 0.10
Here, we
describe GABAB1j, a secreted GABAB1 isoform comprising
the two SDs. 
Localization (secreted) of GABAB1
12) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0.08 Pain Relevance 0.16
Here, we
describe GABAB1j, a secreted GABAB1 isoform comprising
the two SDs. 
Localization (secreted) of GABAB1j
13) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576543 Disease Relevance 0.08 Pain Relevance 0.16
Detailed behavioral and electrophysiological analyses in the paradigms of basal and pathological nociception revealed that although GABAB receptors localized in first order nociceptive neurons have the capacity to modulate sensitization phenomena, their contribution towards the modulation of pain at the level of the whole living organism is not pronounced.
Localization (localized) of GABAB in neurons associated with nociception and pain
14) Confidence 0.71 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.81 Pain Relevance 0.42
Conditioned medium of transfected
HEK293 cells (Lipofectamine 2000, Invitrogen) was collected after 48 h and
used to immunoprecipitate secreted GABAB1 protein. 
Localization (secreted) of GABAB1
15) Confidence 0.70 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0
Membrane-bound GABAB1a protein was
selectively detected in the cell lysate, whereas secreted GABAB1j
protein was additionally detected in the cell-conditioned medium. 
Localization (secreted) of GABAB1j
16) Confidence 0.61 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.07
Indeed, both GABAB1 and GABAB2 mRNAs are co-localized in most brain regions.
Localization (localized) of GABAB1 in brain
17) Confidence 0.45 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.09
Indeed, both GABAB1 and GABAB2 mRNAs are co-localized in most brain regions.
Localization (localized) of GABAB2 in brain
18) Confidence 0.45 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.09
Furthermore, in the absence of GABAB(2), the GABAB(1) protein relocates from distal neuronal sites to the soma and proximal dendrites.
Localization (relocates) of GABAB in proximal
19) Confidence 0.25 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240800 Disease Relevance 0.25 Pain Relevance 0.15
1 (Alomone Labs Inc., Jerusalem, Israel), sheep polyclonal antiserum against GABAB-R1 and GABAB-R2 (gift from Graham Disney and Fiona Marshall, GlaxoWellcome R&D Inc., Stevenage, UK), mouse monoclonal antiserum against PCNA (Merck Biosciences, Schwalbach, Germany) and mouse monoclonal antiserum against ?
Localization (antiserum) of GABAB
20) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.17 Pain Relevance 0.07

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