INT119880

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.55
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Usf1) enzyme binding (Usf1) DNA binding (Usf1)
Anatomy Link Frequency
nervous system 2
Usf1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 36 95.96 Very High Very High Very High
Inflammatory response 8 90.52 High High
Inflammation 90 78.64 Quite High
Neuropathic pain 2 43.52 Quite Low
metalloproteinase 2 5.20 Low Low
cytokine 26 5.00 Very Low Very Low Very Low
Kinase C 24 5.00 Very Low Very Low Very Low
Neuropeptide 18 5.00 Very Low Very Low Very Low
dexamethasone 18 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 8 97.96 Very High Very High Very High
Diabetes Mellitus 8 97.28 Very High Very High Very High
Hyponatremia 10 95.12 Very High Very High Very High
Overactive Bladder 122 93.48 High High
Small Cell Lung Carcinoma 2 91.52 High High
INFLAMMATION 104 90.12 High High
Cancer 26 89.88 High High
Targeted Disruption 26 77.72 Quite High
Cystitis 4 75.04 Quite High
Neurodegenerative Disease 2 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results, together with our finding that the depolarization-sensitive upstream stimulatory factor (USF) binds to a composite CREB/ATF4/USF regulatory element only in the absence of CREB binding, indicate that selective control of alternative GABA(B)R1 promoters by CREB, ATF4, and USF may dynamically regulate expression of their gene products in the nervous system.
upstream stimulatory factor Binding (binds) of in nervous system associated with gaba
1) Confidence 0.20 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240803 Disease Relevance 0.08 Pain Relevance 0.55
These results, together with our finding that the depolarization-sensitive upstream stimulatory factor (USF) binds to a composite CREB/ATF4/USF regulatory element only in the absence of CREB binding, indicate that selective control of alternative GABA(B)R1 promoters by CREB, ATF4, and USF may dynamically regulate expression of their gene products in the nervous system.
USF Binding (binds) of in nervous system associated with gaba
2) Confidence 0.20 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240803 Disease Relevance 0.08 Pain Relevance 0.50
USF dimerizes to regulate transcription through E-box motifs in target genes.
USF Binding (dimerizes) of
3) Confidence 0.19 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.56 Pain Relevance 0.08
Upstream stimulatory factor 1 (USF1) and USF2 contribute to the ectopic vasopressin gene expression in the SCLC cells, by the binding of the E-box element in the vasopressin gene promoter region (Coulson et al. 1999a).
Upstream stimulatory factor 1 Binding (contribute) of associated with small cell lung cancer
4) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.53 Pain Relevance 0
Upstream stimulatory factor 1 (USF1) and USF2 contribute to the ectopic vasopressin gene expression in the SCLC cells, by the binding of the E-box element in the vasopressin gene promoter region (Coulson et al. 1999a).
USF1 Binding (contribute) of associated with small cell lung cancer
5) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.52 Pain Relevance 0
Others have shown that USF binding activity is enhanced in response to LPS [56].
USF Binding (binding) of
6) Confidence 0.14 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.78 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox