INT119888

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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Usf1) DNA binding (Creb1, Usf1) mitochondrion (Creb1)
enzyme binding (Usf1) transcription factor binding (Creb1)
Anatomy Link Frequency
nervous system 2
Creb1 (Mus musculus)
Usf1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 36 95.96 Very High Very High Very High
Neuropathic pain 2 43.52 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 77.72 Quite High
Epilepsy 2 44.04 Quite Low
Neuropathic Pain 2 43.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results, together with our finding that the depolarization-sensitive upstream stimulatory factor (USF) binds to a composite CREB/ATF4/USF regulatory element only in the absence of CREB binding, indicate that selective control of alternative GABA(B)R1 promoters by CREB, ATF4, and USF may dynamically regulate expression of their gene products in the nervous system.
CREB Binding (binds) of USF in nervous system associated with gaba
1) Confidence 0.18 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240803 Disease Relevance 0.08 Pain Relevance 0.50
These results, together with our finding that the depolarization-sensitive upstream stimulatory factor (USF) binds to a composite CREB/ATF4/USF regulatory element only in the absence of CREB binding, indicate that selective control of alternative GABA(B)R1 promoters by CREB, ATF4, and USF may dynamically regulate expression of their gene products in the nervous system.
CREB Binding (binds) of upstream stimulatory factor in nervous system associated with gaba
2) Confidence 0.18 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240803 Disease Relevance 0.08 Pain Relevance 0.56

General Comments

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