INT119892

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 54
Total Number 56
Disease Relevance 23.76
Pain Relevance 9.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
Caco-2 4
epithelial cells 3
lungs 3
fat 2
intestinal cells 1
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1490 100.00 Very High Very High Very High
Bile 161 100.00 Very High Very High Very High
cINOD 18 99.82 Very High Very High Very High
aspirin 106 99.20 Very High Very High Very High
Chronic pancreatitis 15 97.28 Very High Very High Very High
imagery 18 96.76 Very High Very High Very High
Inflammation 322 93.28 High High
bradykinin 10 87.68 High High
Bioavailability 4 84.40 Quite High
sodium channel 30 84.32 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 1490 100.00 Very High Very High Very High
Targeted Disruption 72 100.00 Very High Very High Very High
Pseudomonas Infection 71 99.76 Very High Very High Very High
Disorder Of Lipid Metabolism 302 99.72 Very High Very High Very High
INFLAMMATION 271 99.70 Very High Very High Very High
Infection 185 99.68 Very High Very High Very High
Congenital Anomalies 161 99.50 Very High Very High Very High
Stress 30 99.20 Very High Very High Very High
Non-genital Cutaneous Warts 5 98.76 Very High Very High Very High
Pancreatitis 22 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a recent study demonstrated that CFTR is also expressed in tracheal SMC and may contribute to bronchodilation [36].
Gene_expression (expressed) of CFTR
1) Confidence 0.77 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.93 Pain Relevance 0.31
Mock-infected cells expressed a level of CFTR gene and protein, which was similar to non-infected cells and were, therefore, used as controls in subsequent experiments.
Gene_expression (expressed) of CFTR gene
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.09 Pain Relevance 0
To elucidate the mechanisms underlying the significant raise of FA upon reduction in CFTR expression, we assessed the expression of two proteins involved in FA intestinal uptake and transport.
Gene_expression (expression) of CFTR
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.17 Pain Relevance 0
Finally, specific transcription factors involved in the regulation of lipid metabolism are strongly suppressed in the presence of reduced CFTR expression.
Gene_expression (expression) of CFTR
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.27 Pain Relevance 0.11
Using the intestinal Caco-2/15 cell model, we could show that, reduced CFTR expression distinctively affects the different classes of FA.
Gene_expression (expression) of CFTR in Caco-2
5) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.44 Pain Relevance 0.14
Aspirin and some other nonsteroidal anti-inflammatory drugs inhibit cystic fibrosis transmembrane conductance regulator protein gene expression in T-84 cells.


Gene_expression (expression) of cystic fibrosis transmembrane conductance regulator protein gene associated with fibrosis, aspirin, inflammation, cystic fibrosis and cinod
6) Confidence 0.74 Published 1999 Journal Mediators Inflamm Section Title Doc Link PMC1781806 Disease Relevance 1.03 Pain Relevance 0.80
The present study was undertaken to determine whether three nonsteroidal anti-inflammatory drugs (NSAIDs) (aspirin, ibuprofen, and indomethacin) modulate CFTR gene expression in T-84 cells.
Gene_expression (expression) of CFTR gene associated with aspirin, inflammation and cinod
7) Confidence 0.74 Published 1999 Journal Mediators Inflamm Section Abstract Doc Link PMC1781806 Disease Relevance 0.93 Pain Relevance 0.79
The results indicate that NSAIDs can regulate both CFTR gene expression and the function of CFTR-related chloride transport, and suggest that NSAIDs act via multiple transduction pathways.



Gene_expression (expression) of CFTR gene associated with cinod
8) Confidence 0.74 Published 1999 Journal Mediators Inflamm Section Abstract Doc Link PMC1781806 Disease Relevance 0.82 Pain Relevance 0.91
+/+ mice at different intensity as compared to CFTR+/+ cPLA2?
Gene_expression (/) of CFTR
9) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.76 Pain Relevance 0.29
The absence of CFTR or its F508del mutation (known to promote CFTR degradation) may increase cPLA2?
Gene_expression (mutation) of CFTR
10) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.47 Pain Relevance 0.12
The fact that CFTR -/- and CFTR +/+ mice produce comparable levels of LTB4 and cysteinyl-leukotrienes is paradoxical given the enhanced production of free AA in BALF of CFTR -/- mice.
Gene_expression (produce) of CFTR
11) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.18 Pain Relevance 0.12
Thus, in addition to changes in AA levels and cPLAa activity, an increased PGES activity could be a possible interpretation of PGE2 elevation in CFTR -/- mice.
Gene_expression (elevation) of CFTR
12) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.49 Pain Relevance 0.21
Reduction in CFTR expression appears to cause a shift in the balance between energy-yielding and energy-consuming reactions in favor of the latter.
Gene_expression (expression) of CFTR
13) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0
Infection of Caco-2/15 cells with lentivirus carrying CFTR-shRNAi caused a reduction in CFTR gene (61%) and protein (57%) expression when compared to non-infected cells (Figure 1).
Gene_expression (expression) of CFTR gene in Caco-2 associated with infection
14) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.10 Pain Relevance 0
Cells mock-infected with the empty vector plko.1 served as controls since preliminary experiments have shown comparable gene and protein CFTR expression between mock and non-treated cells.


Gene_expression (expression) of CFTR
15) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.16 Pain Relevance 0
CFTR disruption did not influence the expression of PPAR-?
Gene_expression (disruption) of CFTR
16) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.05 Pain Relevance 0.03
shRNAs targeting CFTR and individually cloned into plko.1-puromycin vector (Open Biosystems, Huntsville, AL) were used to generate lentiviral particles in HEK293FT packaging cells.
Gene_expression (targeting) of CFTR
17) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.10 Pain Relevance 0
Furthermore, the present findings have revealed that CFTR reduced expression is associated with increased de novo lipogenesis.
Gene_expression (expression) of CFTR
18) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 1.09 Pain Relevance 0.25
-oxidation or lipid peroxidation as a consequence of oxidative stress, altered desaturase activity, enhanced production of eicosanoids and defective CFTR.
Gene_expression (production) of CFTR associated with stress
19) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.43 Pain Relevance 0.12
The most striking observation, in response to CFTR knockdown, was the downregulation of LXR-?
Gene_expression (knockdown) of CFTR
20) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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