INT119909

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.76
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
blood 1
endometrium 1
submandibular glands 1
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
Nortriptyline 10 100.00 Very High Very High Very High
Opioid 8 99.78 Very High Very High Very High
Buprenorphine 12 99.40 Very High Very High Very High
Oxycodone 9 99.24 Very High Very High Very High
methadone 15 99.20 Very High Very High Very High
Paracetamol 9 99.00 Very High Very High Very High
fluoxetine 8 98.98 Very High Very High Very High
addiction 6 97.52 Very High Very High Very High
Central nervous system 1 97.52 Very High Very High Very High
tail-flick 4 92.20 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 97.80 Very High Very High Very High
Salivary Gland Disease 1 95.84 Very High Very High Very High
Drug Induced Neurotoxicity 3 93.36 High High
Targeted Disruption 3 87.00 High High
Necrosis 1 57.04 Quite High
Cancer 1 56.68 Quite High
Pain 2 53.28 Quite High
Endometriosis (extended) 2 50.00 Quite Low
Hyperalgesia 1 50.00 Quite Low
Intellectual Impairment 1 29.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this investigation is to evaluate the pharmacokinetic drug interaction between MDMA and fluoxetine and also to determine the role of P-glycoprotein (P-gp) on mediating drug-drug interactions with MDMA.
P-gp Binding (interactions) of associated with fluoxetine
1) Confidence 0.36 Published 2008 Journal J Pharm Sci Section Abstract Doc Link 17724664 Disease Relevance 0.09 Pain Relevance 0.34
The objective of this study was to evaluate the P-gp affinity status of methadone, buprenorphine and diprenorphine to predict P-gp-mediated drug-drug interactions and to determine a better candidate for management of opioid dependence.
P-gp Binding (interactions) of associated with addiction, methadone, opioid and buprenorphine
2) Confidence 0.32 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19370547 Disease Relevance 0.16 Pain Relevance 1.01
Buprenorphine most likely is not a P-gp substrate and concerns regarding P-gp-mediated drug-drug interaction are not expected.
P-gp Neg (not) Binding (interaction) of associated with buprenorphine
3) Confidence 0.30 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19370547 Disease Relevance 0.16 Pain Relevance 1.43
The interaction of NT with P-gp in vitro was confirmed by measurement of P-gp stimulated ATPase activity (Km = 257.6 microM, Vmax = 51.0 nmol phosphate released/mg protein-min).
P-gp Binding (interaction) of associated with nortriptyline
4) Confidence 0.29 Published 2006 Journal Drug Metabol Drug Interact Section Abstract Doc Link 16841511 Disease Relevance 0.08 Pain Relevance 0.29
PURPOSE: To quantify the in vivo role of P-glycoprotein (P-gp) in the pharmacokinetics of methadone after intravenous and oral administration, using valspodar as a P-gp inhibitor.
P-gp Binding (role) of associated with methadone
5) Confidence 0.18 Published 2007 Journal Pharm. Res. Section Abstract Doc Link 17380267 Disease Relevance 0 Pain Relevance 0.17
With certain people, before they've come in, you've already perceived it's going to be difficult because that's your prior expectation, your prior knowledge of them.....I mean and they could be coming with something totally different, but your initial reaction is "oh my god" [PGP16]
PGP16 Binding (reaction) of
6) Confidence 0.13 Published 2008 Journal BMC Fam Pract Section Body Doc Link PMC2533666 Disease Relevance 0.05 Pain Relevance 0.05
UNLABELLED: Loperamide is a peripherally acting antidiarrheal opioid with some affinity for P-glycoprotein (P-gp).
P-gp Binding (affinity) of associated with opioid
7) Confidence 0.11 Published 2004 Journal Drug Dev Ind Pharm Section Abstract Doc Link 15244080 Disease Relevance 0 Pain Relevance 0.15
They also had a significantly lower immunoreactivity to Trpv1 in eutopic endometrium, to Pkcepsilon in ectopic endometrium and to Pgp9.5 in vagina.
Pgp9 Binding (immunoreactivity) of in endometrium
8) Confidence 0.05 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20118114 Disease Relevance 0.11 Pain Relevance 0
However, the constant S/P ratio during acetaminophen disposition and the finding that P-glycoprotein (P-gp), a protein recognized to pump substrates out of the cell, is expressed in duct cells of the submandibular glands questions the mechanisms involved in acetaminophen salivary secretion.
P-gp Binding (recognized) of in submandibular glands associated with paracetamol
9) Confidence 0.03 Published 2004 Journal Arch. Oral Biol. Section Abstract Doc Link 15353245 Disease Relevance 0.10 Pain Relevance 0.66
This has important clinical implications, as it indicates that oxycodone, unlike some other opioids, will not interact at the blood-brain barrier (BBB) with concomitantly administered P-gp substrates.
P-gp Neg (not) Binding (interact) of in blood associated with oxycodone and opioid
10) Confidence 0.01 Published 2005 Journal J Pharm Sci Section Abstract Doc Link 15799017 Disease Relevance 0 Pain Relevance 0.97

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