INT119914

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 1
Olr1714 (Rattus norvegicus)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 6 99.92 Very High Very High Very High
Thermal hyperalgesia 2 94.08 High High
intrathecal 2 79.52 Quite High
Hyperalgesia 2 75.60 Quite High
Antinociceptive 4 68.72 Quite High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 4 94.08 High High
Hypertension 2 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ONO-1714 potently inhibited both crude rat cerebellar NOS and recombinant human nNOS in vitro.
ONO-1714 Negative_regulation (inhibited) of nNOS
1) Confidence 0.02 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15245789 Disease Relevance 0.25 Pain Relevance 0.54
We evaluated if ONO-1714, known as an inducible nitric oxide synthase (iNOS) inhibitor, could inhibit neuronal NOS (nNOS) and exert antinociception.
ONO-1714 Negative_regulation (inhibit) of nNOS in neuronal associated with antinociception
2) Confidence 0.02 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15245789 Disease Relevance 0.22 Pain Relevance 0.47

General Comments

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