INT119917

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 1.82

plasma membrane (Oprd1) intracellular (Zfp821) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency medulla 3 pons 1 Zfp821 (Rattus norvegicus) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 16 100.00 medulla 2 100.00 antinociception 6 93.68 tail-flick 2 91.84 agonist 6 88.52 mu opioid receptor 2 67.84 antagonist 6 66.32 Kappa opioid receptor 2 61.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TAN-821 stimulated the binding of the nonhydrolyzable guanosine 5'-triphosphate analog, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via the activation of putative epsilon opioid receptor.

TAN-821 Positive_regulation (stimulated) of Positive_regulation (activation) of epsilon opioid receptor in medulla associated with medulla and opioid receptor

1) Confidence 0.01 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15246090 Disease Relevance 0 Pain Relevance 0.91

TAN-821 stimulated the binding of the nonhydrolyzable guanosine 5'-triphosphate analog, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via the activation of putative epsilon opioid receptor.

TAN-821 Positive_regulation (stimulated) of in pons Positive_regulation (activation) of epsilon opioid receptor in medulla associated with medulla and opioid receptor

2) Confidence 0.00 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15246090 Disease Relevance 0 Pain Relevance 0.91

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