INT119918

Context Info Confidence 0.00 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 1.64

generation of precursor metabolites and energy (ACAA1) small molecule metabolic process (ACAA1) peroxisome (ACAA1) intracellular (Zfp821)

Anatomy Link Frequency medulla 3 pons 1 Zfp821 (Rattus norvegicus) ACAA1 (Homo sapiens)

Pain Link Frequency Relevance Heat medulla 2 98.16 opioid receptor 16 97.44 agonist 6 88.52 antinociception 6 84.32 tail-flick 2 82.48 mu opioid receptor 2 58.48 antagonist 6 56.96 Kappa opioid receptor 2 51.68

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TAN-821 stimulated the binding of the nonhydrolyzable guanosine 5'-triphosphate analog, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via the activation of putative epsilon opioid receptor.

TAN-821 Positive_regulation (stimulated) of gamma-thio Binding (binding) of in medulla associated with medulla and opioid receptor

1) Confidence 0.00 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15246090 Disease Relevance 0 Pain Relevance 0.82

TAN-821 stimulated the binding of the nonhydrolyzable guanosine 5'-triphosphate analog, guanosine 5'-(gamma-thio)-triphosphate (GTPgammaS), to the mouse pons/medulla membrane via the activation of putative epsilon opioid receptor.

TAN-821 Positive_regulation (stimulated) of gamma-thio in pons Binding (binding) of in medulla associated with medulla and opioid receptor

2) Confidence 0.00 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15246090 Disease Relevance 0 Pain Relevance 0.82

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