INT119940

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 18.87
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
dorsal 8
CPu 6
dentate gyrus 4
adult brain 4
amygdala 4
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 235 100.00 Very High Very High Very High
withdrawal 42 99.88 Very High Very High Very High
amygdala 148 99.68 Very High Very High Very High
Morphine 78 99.66 Very High Very High Very High
narcan 8 99.56 Very High Very High Very High
projection neuron 9 98.82 Very High Very High Very High
Hippocampus 370 98.72 Very High Very High Very High
Enkephalin 30 98.64 Very High Very High Very High
mu opioid receptor 22 98.36 Very High Very High Very High
c fibre 4 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1135 100.00 Very High Very High Very High
Urological Neuroanatomy 6 99.68 Very High Very High Very High
Retinal Degeneration 58 98.24 Very High Very High Very High
Encephalitis 6 96.92 Very High Very High Very High
Targeted Disruption 37 94.08 High High
Cognitive Disorder 178 92.08 High High
Apoptosis 20 90.76 High High
Retrograde Degeneration 2 89.28 High High
Injury 20 86.36 High High
Hyperphagia 7 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dendritic expression of the activity-regulated cytoskeleton-associated protein (Arc) is dramatically enhanced by increased synaptic activity in adult brain.
Positive_regulation (enhanced) of Gene_expression (expression) of Arc in adult brain associated with aids-related complex
1) Confidence 0.70 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.32 Pain Relevance 0.14
In addition, we found that conditioned morphine withdrawal also increased activity-regulated cytoskeletal-associated protein (Arc) expression in the amygdala but not in the DH, although actin rearrangements were observed in both areas.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Arc in amygdala associated with aids-related complex, hippocampus, amygdala, withdrawal and morphine
2) Confidence 0.64 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19793983 Disease Relevance 0.10 Pain Relevance 1.48
Ensure cues increased arc expression in limbic regions including the dorsal hippocampus and the basolateral amygdala, but not in the central nucleus of the amygdala.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of arc in hippocampus associated with aids-related complex, hippocampus and amygdala
3) Confidence 0.54 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.54 Pain Relevance 0.29
Dendritic expression of the activity-regulated cytoskeleton-associated protein (Arc) is dramatically enhanced by increased synaptic activity in adult brain.
Positive_regulation (enhanced) of Gene_expression (expression) of activity-regulated cytoskeleton-associated protein in adult brain associated with aids-related complex
4) Confidence 0.50 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.32 Pain Relevance 0.14
IEG upregulation after a few (Ribeiro et al., 1999, 2002) or many (Figure 4) sleep cycles is a plausible explanation for late waves of arc and zif-268 gene expression upregulation many hours after memory acquisition (Bekinschtein et al., 2007; Grimm and Tischmeyer, 1997).
Positive_regulation (upregulation) of Gene_expression (expression) of arc associated with aids-related complex
5) Confidence 0.49 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.10 Pain Relevance 0.03
As previously noted for WK conditions (Guzowski et al., 2001), the range of arc expression upregulation during REM sleep was twice as large as that of zif-268 (50–60% vs. 20–30%, respectively, Figures 4A and 4B), a difference that fits a direct role of the arc protein on morphological plasticity (Lyford et al., 1995) as well as the indirect, transcriptional role played by the zif-268 protein (Thiel et al., 1994; Wisden et al., 1990).
Positive_regulation (upregulation) of Gene_expression (expression) of arc associated with aids-related complex
6) Confidence 0.49 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.34 Pain Relevance 0.19
Indeed, IEG reinduction during REM sleep may explain the second wave of arc protein expression detected 8–24?
Positive_regulation (during) of Gene_expression (expression) of arc protein associated with aids-related complex
7) Confidence 0.49 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.20 Pain Relevance 0
These data indicate that mu opioid receptor activation contributes to METH-induced gene expression in the CPu and stereotypy, and that patch-enhanced PD and arc expression may be a homeostatic response to METH treatment.
Positive_regulation (enhanced) of Gene_expression (expression) of arc in CPu associated with aids-related complex and mu opioid receptor
8) Confidence 0.49 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20298714 Disease Relevance 0.41 Pain Relevance 0.19
In the present study, we examined the expression of Arc protein induced by conditioned naloxone-precipitated drug withdrawal in different brain regions of acute morphine-dependent rats.
Spec (examined) Positive_regulation (induced) of Spec (examined) Gene_expression (expression) of Arc in brain associated with aids-related complex, narcan, withdrawal and morphine
9) Confidence 0.46 Published 2009 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 19262551 Disease Relevance 0.35 Pain Relevance 0.31
expression of Arc, Narp, and Zif268 in the dentate gyrus after training rats in
Positive_regulation (after) of Gene_expression (expression) of Arc in dentate gyrus associated with aids-related complex
10) Confidence 0.46 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.49 Pain Relevance 0.06
blades of the dentate gyrus, whereas Arc and Narp expression are selectively
Positive_regulation (whereas) of Gene_expression (expression) of Arc in dentate gyrus associated with aids-related complex
11) Confidence 0.46 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.81 Pain Relevance 0
The density of Arc
Positive_regulation (density) of Gene_expression (density) of Arc associated with aids-related complex
12) Confidence 0.46 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.59 Pain Relevance 0
Arc levels were elevated more than
Positive_regulation (elevated) of Gene_expression (levels) of Arc associated with aids-related complex
13) Confidence 0.46 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.63 Pain Relevance 0
When rats are allowed to eat beyond satiety in the presence of a discrete cue that had been previously paired with food delivery when hungry, lateral hypothalamus projection neurons in the basolateral amygdala and prefrontal cortex exhibit increased homer1a and arc expression [58].
Positive_regulation (increased) of Gene_expression (expression) of arc in hypothalamus associated with aids-related complex, projection neuron and amygdala
14) Confidence 0.45 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.39 Pain Relevance 0.39
Sustained synthesis of Arc during a surprisingly protracted time-window is required for hyperphosphorylation of actin depolymerizing factor/cofilin and local expansion of the actin cytoskeleton in vivo.
Positive_regulation (required) of Gene_expression (synthesis) of Arc associated with aids-related complex
15) Confidence 0.45 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.88 Pain Relevance 0.26
Interestingly, no significant increase of Arc expression was observed
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of Arc associated with aids-related complex
16) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.77 Pain Relevance 0
Thus, enhancement of Arc expression in the dorsal blade of the DG
Positive_regulation (enhancement) of Gene_expression (expression) of Arc in dorsal associated with aids-related complex
17) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.72 Pain Relevance 0
induced in the dorsal blade. (3) The levels of Arc, ?
Positive_regulation (induced) of Gene_expression (levels) of Arc in dorsal associated with aids-related complex
18) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.82 Pain Relevance 0
objects resulted in a 2-fold increase in Arc-expression at 10 minutes (P = .05)
Positive_regulation (increase) of Gene_expression (expression) of Arc associated with aids-related complex
19) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.67 Pain Relevance 0
increase of Arc expression in the dorsal blade.
Positive_regulation (increase) of Gene_expression (expression) of Arc in dorsal associated with aids-related complex
20) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.77 Pain Relevance 0

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