INT11996

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 4.80
Pain Relevance 13.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ina) structural molecule activity (Ina)
Anatomy Link Frequency
neurons 3
hair cells 2
internal 1
nociceptors 1
neurite 1
Ina (Rattus norvegicus)
Pain Link Frequency Relevance Heat
inferior alveolar nerve 604 100.00 Very High Very High Very High
tetrodotoxin 325 100.00 Very High Very High Very High
depression 7 100.00 Very High Very High Very High
Mexiletine 6 99.98 Very High Very High Very High
Endep 6 99.98 Very High Very High Very High
trigeminal ganglion 312 99.84 Very High Very High Very High
Hyperalgesia 6 99.68 Very High Very High Very High
Action potential 191 99.56 Very High Very High Very High
halothane 16 99.56 Very High Very High Very High
local anesthetic 5 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 8 100.00 Very High Very High Very High
Ganglion Cysts 343 99.84 Very High Very High Very High
Hyperalgesia 6 99.68 Very High Very High Very High
INFLAMMATION 1 99.16 Very High Very High Very High
Heart Rate Under Development 24 97.40 Very High Very High Very High
Inflammatory Pain 2 94.04 High High
Diastolic Heart Failure 2 91.80 High High
Diabetes Mellitus 9 90.68 High High
Nervous System Injury 68 89.40 High High
Pain 46 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M TTX compared to those before TTX administration, suggesting that some neurons in both groups included TTX-S as well as TTX-R INa components.
Gene_expression (included) of INa in neurons associated with tetrodotoxin
1) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.13 Pain Relevance 1.51
TTX-R INa was much larger than TTX-S INa in both naive and IAN-transected rats (Figure 4Ac, d, e, f).
Gene_expression (rats) of INa associated with tetrodotoxin and inferior alveolar nerve
2) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.30 Pain Relevance 1.90
Change in INa, IA and Ik, and ability to generate action potentials in TG neurons
Gene_expression (Change) of INa in neurons associated with action potential and trigeminal ganglion
3) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.48 Pain Relevance 0.89
In agreement with this finding, the present study revealed that both TTX-R INa and -S INa densities of TG neurons were significantly larger in IAN-transected rats (14 days after transection) compared with those in naive rats (Figure 4).
Gene_expression (densities) of INa in neurons associated with tetrodotoxin, inferior alveolar nerve and trigeminal ganglion
4) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 1.09 Pain Relevance 1.43
When the cells were stimulated infrequently (less than 1 Hz), both drugs produced dose-dependent depression of INa, which was correlated with one-to-one binding to sodium channel.
Gene_expression (produced) of INa associated with depression and sodium channel
5) Confidence 0.53 Published 1985 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2411942 Disease Relevance 0.10 Pain Relevance 0.29
Mexiletine produced a marked use-dependent blockage of INa, whereas disopyramide did not produce significant use-dependent block under similar experimental conditions.
Gene_expression (produced) of INa associated with mexiletine
6) Confidence 0.53 Published 1985 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2411942 Disease Relevance 0.09 Pain Relevance 0.31
The drug also produced an additional use-dependent block of INa, which depended on the frequency of the voltage clamp pulse.
Gene_expression (produced) of INa
7) Confidence 0.53 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6089001 Disease Relevance 0 Pain Relevance 0.25
The second aspect dealt with cell excitability as revealed by voltage-dependent Na current (INa) expression.
Gene_expression (expression) of INa
8) Confidence 0.53 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8131265 Disease Relevance 0 Pain Relevance 0.33
Immature action potentials and their underlying INaS were present in a small proportion of E12 cells.
Gene_expression (present) of INaS associated with action potential
9) Confidence 0.53 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8131265 Disease Relevance 0 Pain Relevance 0.34
The earliest expressed somatic INa has been characterized and compared with that present at a later date. 2.
Gene_expression (expressed) of INa
10) Confidence 0.52 Published 1991 Journal J. Neurophysiol. Section Abstract Doc Link 1651371 Disease Relevance 0 Pain Relevance 0.09
During this period, INa was present in most (31/43) type I hair cells irrespective of their position in the crista, in most type II hair cells located far from the planum semilunatum (48/63), but only occasionally in type II hair cells close to the planum semilunatum (2/35).
Gene_expression (present) of INa in hair cells
11) Confidence 0.52 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12702715 Disease Relevance 0 Pain Relevance 0.07
Here we describe that chick hair cells, from the semicircular canals, begin expressing a voltage-dependent Na current (INa) from embryonic day 14 (E14) and continue to express the current up to hatching (E21).
Gene_expression (expressing) of INa in hair cells
12) Confidence 0.52 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12702715 Disease Relevance 0 Pain Relevance 0.06
INaP and IS were present both in cells resembling medium spiny neurons and in cells resembling aspiny interneurons. 6.
Gene_expression (present) of INaP in interneurons
13) Confidence 0.52 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7500162 Disease Relevance 0 Pain Relevance 0.14
However, it did produce use-dependent blockade of INa when it was placed internally at a concentration of 200 microM.
Gene_expression (produce) of INa
14) Confidence 0.52 Published 1984 Journal J. Membr. Biol. Section Abstract Doc Link 6088775 Disease Relevance 0 Pain Relevance 0.16
Its effects, when placed in the internal solution, are similar to those of permanently charged local anesthetic derivatives, which also produce use-dependent block of INa.
Gene_expression (produce) of INa in internal associated with local anesthetic
15) Confidence 0.52 Published 1984 Journal J. Membr. Biol. Section Abstract Doc Link 6088775 Disease Relevance 0 Pain Relevance 0.18
Halothane at 0.6 mM and 1.2 mM produced significant (P < 0.05) depressions of peak INa of 12.3% +/- 1.8% and 24.4% +/- 4.1% (mean +/- SEM, n = 12), respectively.
Gene_expression (produced) of INa associated with depression and halothane
16) Confidence 0.52 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9024016 Disease Relevance 0.26 Pain Relevance 0.43
We regarded INa evoked by conditioning pulses and test pulses to ?
Gene_expression (regarded) of INa
17) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453160 Disease Relevance 0 Pain Relevance 0.09
Effects of QDs on properties of INa inactivation
Gene_expression (inactivation) of INa
18) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453160 Disease Relevance 0 Pain Relevance 0
Effects of QDs on the properties of INa activation
Gene_expression (properties) of INa
19) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453160 Disease Relevance 0 Pain Relevance 0.29
Representative traces of INa in control and in 10 nM QDs are presented in Figure 4A; 10 and 20 nM QDs induced depolarizing shifts of peak voltage, at which the current amplitudes reached the maximum, to approximately ?
Gene_expression (traces) of INa
20) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453160 Disease Relevance 0 Pain Relevance 0.25

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