INT119994

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.04
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2)
transmembrane transport (Trpv2) cytoplasm (Trpv2)
Anatomy Link Frequency
muscle fibers 1
Nociceptors 1
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 3 100.00 Very High Very High Very High
nociceptor 10 99.98 Very High Very High Very High
Inflammation 1 87.48 High High
qutenza 6 86.96 High High
Thermal hyperalgesia 1 86.84 High High
fibrosis 3 85.84 High High
Pain 2 81.80 Quite High
tissue acidosis 1 79.60 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Frailty 12 99.48 Very High Very High Very High
Targeted Disruption 10 97.08 Very High Very High Very High
Muscle Disease 3 96.24 Very High Very High Very High
Nociception 2 95.04 Very High Very High Very High
Muscle Weakness 3 93.96 High High
Disease 3 92.44 High High
INFLAMMATION 1 87.48 High High
Hyperalgesia 1 86.84 High High
Fibrosis 3 85.84 High High
Apoptosis 3 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that muscular dystrophy is ameliorated in two animal models, dystrophin-deficient mdx mice and delta-sarcoglycan-deficient BIO14.6 hamsters by dominant-negative inhibition of the transient receptor potential cation channel, TRPV2, a principal candidate for Ca(2+)-entry pathways.
Negative_regulation (inhibition) of TRPV2 associated with member 8 and frailty
1) Confidence 0.58 Published 2009 Journal Hum. Mol. Genet. Section Abstract Doc Link 19050039 Disease Relevance 0.87 Pain Relevance 0.13
When transgenic (Tg) mice expressing a TRPV2 mutant in muscle were crossed with mdx mice, the [Ca(2+)](i) increase in muscle fibers was reduced by dominant-negative inhibition of endogenous TRPV2.
Negative_regulation (inhibition) of TRPV2 in muscle fibers associated with targeted disruption
2) Confidence 0.58 Published 2009 Journal Hum. Mol. Genet. Section Abstract Doc Link 19050039 Disease Relevance 0.87 Pain Relevance 0.13
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses.
Negative_regulation (lacking) of TRPV2 in Nociceptors associated with nociceptor
3) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Title Doc Link 15254097 Disease Relevance 0.10 Pain Relevance 0.46
Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models.
Negative_regulation (inhibition) of TRPV2 associated with frailty
4) Confidence 0.37 Published 2009 Journal Hum. Mol. Genet. Section Title Doc Link 19050039 Disease Relevance 0.80 Pain Relevance 0.10
However, mice deficient of TRPV2 and TRPV1 or TRPV3 or TRPV4 show no major impairment of noxious heat sensing.
Negative_regulation (deficient) of TRPV2
5) Confidence 0.34 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19404626 Disease Relevance 0.41 Pain Relevance 0.76

General Comments

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