INT1200

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2011
Negated 5
Speculated 3
Reported most in Abstract
Documents 274
Total Number 277
Disease Relevance 155.17
Pain Relevance 56.14

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extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 36
blood 19
liver 9
body 7
fat 5
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 560 100.00 Very High Very High Very High
Cholecystokinin 73 100.00 Very High Very High Very High
antagonist 73 100.00 Very High Very High Very High
Somatostatin 28 100.00 Very High Very High Very High
opiate 14 100.00 Very High Very High Very High
anesthesia 191 99.98 Very High Very High Very High
Nicotine 159 99.98 Very High Very High Very High
Chronic pancreatitis 62 99.94 Very High Very High Very High
Enkephalin 32 99.90 Very High Very High Very High
tolerance 445 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4313 100.00 Very High Very High Very High
Body Weight 788 100.00 Very High Very High Very High
Insulin Resistance 764 100.00 Very High Very High Very High
Obesity 753 100.00 Very High Very High Very High
INFLAMMATION 651 100.00 Very High Very High Very High
Burns 9 100.00 Very High Very High Very High
Hyperphagia 34 99.96 Very High Very High Very High
Pancreatitis 112 99.94 Very High Very High Very High
Hyperglycemia 454 99.92 Very High Very High Very High
Polycystic Ovary Syndrome 80 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with chronic pancreatitis a decrease in insulin activity of blood was observed.
Negative_regulation (decrease) of insulin in blood associated with chronic pancreatitis
1) Confidence 0.58 Published 1975 Journal Vopr. Med. Khim. Section Abstract Doc Link 1119116 Disease Relevance 0.35 Pain Relevance 0.34
In blood serum of the patients no effect of inhibition of the insulin activity could be observed by means of influence of insulin on lipolysis in epididymal rat adipose tissue.
Negative_regulation (inhibition) of insulin in adipose tissue associated with obesity
2) Confidence 0.58 Published 1975 Journal Vopr. Med. Khim. Section Abstract Doc Link 1119116 Disease Relevance 0.44 Pain Relevance 0.39
Actually, a significant rapid decrease in blood glucose, plasma insulin and hepatic glycogen content was observed.
Negative_regulation (decrease) of insulin in blood
3) Confidence 0.58 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2087480 Disease Relevance 0.35 Pain Relevance 0
Fifteen to 18 h after cessation of infusion, the glucose levels of both strains had fallen to below those of the respective controls whereas the insulin levels remained suppressed.
Negative_regulation (suppressed) of insulin associated with sprains and strains
4) Confidence 0.58 Published 1989 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2569528 Disease Relevance 0.43 Pain Relevance 0.21
Like the obese animals, lean rats exhibited a decrease in insulin sensitivity with age.
Negative_regulation (decrease) of insulin associated with obesity
5) Confidence 0.58 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989847 Disease Relevance 1.53 Pain Relevance 0.20
When the hypoglycemic effect of stress was prevented by glucose injection into ADR rats the decrease in plasma insulin and hepatic glycogen was not observed.
Negative_regulation (decrease) of insulin in plasma associated with stress
6) Confidence 0.58 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2087480 Disease Relevance 0.34 Pain Relevance 0
Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats.
Negative_regulation (deficiency) of insulin associated with hyperalgesia and nociceptor
7) Confidence 0.58 Published 2006 Journal Neurobiol. Dis. Section Title Doc Link 16935517 Disease Relevance 1.08 Pain Relevance 0.88
Nicotine reduced body weight and plasma insulin in female and male rats.
Negative_regulation (reduced) of insulin in plasma associated with body weight and nicotine
8) Confidence 0.58 Published 1994 Journal Life Sci. Section Abstract Doc Link 8057754 Disease Relevance 0.35 Pain Relevance 0.36
Depressed hepatic insulin extraction was indicated by a 37-47% reduction in insulin uptake by in situ perfused livers as well as alterations in portal-hepatic venous insulin differences and intravenous insulin tolerance tests in vivo.
Negative_regulation (reduction) of insulin in livers associated with tolerance
9) Confidence 0.58 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 6989267 Disease Relevance 0.16 Pain Relevance 0.13
The relaxing effect of insulin on the isolated rat duodenum was inhibited by sodium orthovanadate, trifluoperazine, verapamil, aspirin and dexamethasone, non-competitively. 4.
Negative_regulation (inhibited) of insulin in duodenum associated with aspirin and dexamethasone
10) Confidence 0.58 Published 1989 Journal Gen. Pharmacol. Section Abstract Doc Link 2666256 Disease Relevance 0.14 Pain Relevance 0.28
Finally, to assess the reliability of these indexes for the identification of animals with impaired insulin sensitivity, performance of the indexes was analyzed by receiver operating characteristic (ROC) curves in Wistar and Sprague-Dawley rats.
Negative_regulation (impaired) of insulin
11) Confidence 0.58 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18796548 Disease Relevance 0.08 Pain Relevance 0.05
Fasting caused a 10.5% decrease in insulin action per hour over six hours.
Negative_regulation (decrease) of insulin
12) Confidence 0.57 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11911229 Disease Relevance 0.34 Pain Relevance 0.08
Atropine produced a 56% inhibition of insulin action in fed rats.
Negative_regulation (inhibition) of insulin
13) Confidence 0.57 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11911229 Disease Relevance 0.27 Pain Relevance 0.09
The effect may be due to a capacity of insulin to produce analgesia through an action on one or more neurotransmitter receptors.
Negative_regulation (capacity) of insulin associated with neurotransmitter and analgesia
14) Confidence 0.57 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15155333 Disease Relevance 0.09 Pain Relevance 0.54
However, extended passage was associated with a decline in cellular insulin content (83% decline over 89 passages).
Negative_regulation (decline) of insulin
15) Confidence 0.56 Published 1990 Journal Endocrinology Section Abstract Doc Link 1701127 Disease Relevance 0 Pain Relevance 0.13
Therefore, the effect of CATO on lessening the blood glucose rise was seen even with a short feeding period of 5 days, and might be related with a degree of decrease in the fasting serum insulin levels.
Negative_regulation (decrease) of insulin in blood
16) Confidence 0.56 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 1.09 Pain Relevance 0
Treadmill running for 10 days up to 240 min/day led to a decrease of basal and glucose-stimulated plasma insulin levels without major alterations of the IV glucose tolerance (1 g/kg body weight).
Negative_regulation (decrease) of insulin in body associated with body weight, tolerance and impaired glucose tolerance
17) Confidence 0.55 Published 1979 Journal Diabetologia Section Abstract Doc Link 428688 Disease Relevance 0.44 Pain Relevance 0.17
The results of the euglycemic clamp study suggested that the insulin action was significantly impaired by STZ treatment, despite the injection of 2 units of insulin.
Negative_regulation (impaired) of insulin
18) Confidence 0.55 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.36 Pain Relevance 0.04
However, the impaired insulin sensitivity was significantly improved by 7 days administration of insulin combined with GJG or GJG alone.
Negative_regulation (impaired) of insulin
19) Confidence 0.55 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.37 Pain Relevance 0.04
The data from the chronic sleep disturbance experiment might suggest that the elevated glucose levels are caused by a reduced insulin response.
Negative_regulation (reduced) of insulin
20) Confidence 0.55 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2842885 Disease Relevance 0.67 Pain Relevance 0

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