INT120004

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.92
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
joint 2
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 118 94.36 High High
cytokine 9 93.76 High High
ischemia 2 86.64 High High
anesthesia 3 84.20 Quite High
Neuronal nitric oxide synthase 3 83.44 Quite High
rheumatoid arthritis 35 82.16 Quite High
fibrosis 57 79.44 Quite High
Central nervous system 3 75.84 Quite High
Enkephalin 2 75.00 Quite High
Opioid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 15 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 1 99.20 Very High Very High Very High
Apoptosis 115 98.28 Very High Very High Very High
Disease 53 96.76 Very High Very High Very High
Nephrotoxicity 3 95.28 Very High Very High Very High
Arthritis 41 94.36 High High
Parkinson's Disease 2 91.52 High High
Experimental Arthritis 78 87.36 High High
Cv Unclassified Under Development 2 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcription of p53 is probably

increased in response to the toxic environment of the inflamed joint.

Transcription (Transcription) of p53 in joint
1) Confidence 0.72 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.24 Pain Relevance 0.32
Transcription of p53 is

probably increased in response to the toxic environment of the inflamed joint, with local production of oxygen radicals, nitric oxide [30], and cytokines.

Transcription (Transcription) of p53 in joint associated with cytokine
2) Confidence 0.53 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.26 Pain Relevance 0.40
To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels.
Transcription (levels) of p53 associated with apoptosis
3) Confidence 0.52 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473255 Disease Relevance 0.56 Pain Relevance 0.13
CONCLUSION: Our preliminary data show that N2O induced a selective increase in nNOS and p53 transcription.
Transcription (transcription) of p53
4) Confidence 0.52 Published 2010 Journal Minerva Anestesiol Section Body Doc Link 20473255 Disease Relevance 0 Pain Relevance 0
A semi-quantitative RT-PCR analysis was performed on the p53 transcript (using Ciclophylin A as a housekeeping gene).
Transcription (transcript) of p53
5) Confidence 0.50 Published 2010 Journal Minerva Anestesiol Section Body Doc Link 20473255 Disease Relevance 0 Pain Relevance 0
Such neuroprotective effects of DADLE against METH neurotoxicity was accompanied by attenuation of mRNA expressions of a tumor necrosis factor p53 and an immediate early gene c-fos.
Transcription (expressions) of p53 associated with necrosis, drug induced neurotoxicity and cancer
6) Confidence 0.40 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353366 Disease Relevance 0.80 Pain Relevance 0.54
The p53 mRNA expression showed a single peak at 12 weeks.
Transcription (expression) of p53
7) Confidence 0.25 Published 2004 Journal JOP Section Body Doc Link 15254349 Disease Relevance 0.10 Pain Relevance 0
In addition, PFD downregulated mRNA expression of CsA-induced p53 and Fas-ligand and increased that of Bcl-xL, which had previously been reduced by CsA.
Transcription (expression) of p53
8) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.96 Pain Relevance 0.10

General Comments

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