INT12001

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 17
Speculated 22
Reported most in Abstract
Documents 97
Total Number 119
Disease Relevance 54.64
Pain Relevance 76.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 14
DRG 8
neurons 7
dorsal horn 5
muscle 4
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2306 100.00 Very High Very High Very High
Sciatic nerve 198 100.00 Very High Very High Very High
Inflammation 160 100.00 Very High Very High Very High
Pain 153 100.00 Very High Very High Very High
Calcitonin gene-related peptide 112 100.00 Very High Very High Very High
qutenza 98 100.00 Very High Very High Very High
substance P 98 100.00 Very High Very High Very High
Hyperalgesia 80 100.00 Very High Very High Very High
intrathecal 39 100.00 Very High Very High Very High
withdrawal 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 114 100.00 Very High Very High Very High
Pressure And Volume Under Development 11 100.00 Very High Very High Very High
INFLAMMATION 166 99.96 Very High Very High Very High
Rheumatoid Arthritis 8 99.88 Very High Very High Very High
Pain 146 99.84 Very High Very High Very High
Nociception 116 99.84 Very High Very High Very High
Neuropathic Pain 93 99.84 Very High Very High Very High
Neuroleptic Malignant Syndrome 22 99.82 Very High Very High Very High
Ganglion Cysts 178 99.74 Very High Very High Very High
Disease 51 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plantar incision did not change NGF levels in the tibial nerve and L4-L6 dorsal root ganglia.
Neg (not) Regulation (change) of NGF in dorsal root ganglia associated with nerve growth factor
1) Confidence 0.62 Published 2005 Journal Pain Section Abstract Doc Link 16061324 Disease Relevance 0.47 Pain Relevance 0.84
MAM treated animals showed no changes in paw NGF or substance P levels suggesting that the altered nociceptive response is not related to local downregulation of these two molecules.
Neg (no) Regulation (changes) of NGF in paw associated with nociception, nerve growth factor and substance p
2) Confidence 0.62 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10465689 Disease Relevance 0.39 Pain Relevance 0.33
Unlesioned sites did not show any significant changes in NGF levels.
Neg (not) Regulation (changes) of NGF associated with nerve growth factor
3) Confidence 0.62 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 10638445 Disease Relevance 0.22 Pain Relevance 0.57
Thus, the bioactivity of LBD-NGF was not affected by fusing with the LBD peptide.
Neg (not) Regulation (affected) of LBD-NGF associated with nerve growth factor
4) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.05 Pain Relevance 0.95
Arthritis in capsaicin-treated rats had no effect on substance P or NGF levels in any tissue when compared with capsaicin-treated control rats, suggesting that pharmacological impairment of the sensory nervous system can reduce the severity of inflammatory joint disease.
Neg (no) Regulation (effect) of NGF in joint associated with inflammation, nerve growth factor, qutenza, arthropathy, substance p and arthritis
5) Confidence 0.61 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259450 Disease Relevance 1.00 Pain Relevance 1.50
Coexpression of semaphorin3A and NGF at moderate to low concentrations within the adult spinal cord reduced sprouting of calcitonin gene-related peptide and substance P-containing axons compared with GFP and NGF coexpression controls.
Regulation (controls) of NGF in spinal cord associated with substance p, calcitonin gene-related peptide and spinal cord
6) Confidence 0.61 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749426 Disease Relevance 0.66 Pain Relevance 0.63
RESULTS: ALC cotreatment was able to significantly reduce the neurotoxicity of both cisplatin and paclitaxel in rat models, and this effect was correlated with a modulation of the plasma levels of NGF in the cisplatin-treated animals.
Regulation (modulation) of NGF in plasma
7) Confidence 0.60 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 14654561 Disease Relevance 0.07 Pain Relevance 0
We wanted to analyze the NGF regulation of M/KCNQ channels at the single-channel level to determine whether the inhibition can be attributed to a decrease in Po or single-channel conductance.
Spec (analyze) Regulation (regulation) of NGF associated with nerve growth factor
8) Confidence 0.60 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.14 Pain Relevance 0.29
However, it has not been clarified quantitatively whether disc herniation induces changes in nerve growth factor levels in the dorsal root ganglion in relation to pain-related behavior.
Spec (whether) Regulation (changes) of nerve growth factor in dorsal root ganglion
9) Confidence 0.60 Published 2005 Journal Spine Section Body Doc Link 15644754 Disease Relevance 0.08 Pain Relevance 0
Comparable changes in GFAP and NGF could be achieved by treatment of control cultures with interferon-gamma or interleukin-1 beta.
Regulation (changes) of NGF associated with nerve growth factor
10) Confidence 0.59 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7532097 Disease Relevance 0.17 Pain Relevance 0.42
Differential regulation of NGF receptors in primary sensory neurons by adjuvant-induced arthritis in the rat.
Regulation (regulation) of NGF in primary sensory neurons associated with arthritis
11) Confidence 0.58 Published 2001 Journal Pain Section Title Doc Link 11166977 Disease Relevance 0.56 Pain Relevance 0.48
No changes were detected in the substance P content of nine different brain regions, in agreement with previous observations on the lack of effect of NGF on central neurons.
Regulation (effect) of NGF in neurons associated with nerve growth factor and substance p
12) Confidence 0.45 Published 1981 Journal J. Neurosci. Section Abstract Doc Link 6171632 Disease Relevance 0 Pain Relevance 0.95
Effects of morphine on oedema and tissue concentration of nerve growth factor in experimental inflammation of the rat paw.
Regulation (Effects) of nerve growth factor in paw associated with pressure and volume under development, inflammation, nerve growth factor and morphine
13) Confidence 0.45 Published 2002 Journal Pharmacology Section Title Doc Link 12372907 Disease Relevance 0.66 Pain Relevance 0.91
In order to examine the relationship between the action of opioid neurotransmitters and growth factors in the regulation of brain development, we have studied the long-term effect of the opiate antagonist naltrexone (NTX) on the content of nerve growth factor (NGF) in cortex, hippocampus, septum and neostriatum, and on NGF receptor (NGFRs) levels in cortical membranes. 50 mg/kg NTX treatment induced a decrease in the number of 125I-NGF high-affinity binding sites, without detectable changes in NGF levels.
Regulation (effect) of NGF in nerve associated with neurotransmitter, nerve growth factor, antagonist, hippocampus, opiate and opioid
14) Confidence 0.45 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469378 Disease Relevance 0 Pain Relevance 0.83
In order to examine the relationship between the action of opioid neurotransmitters and growth factors in the regulation of brain development, we have studied the long-term effect of the opiate antagonist naltrexone (NTX) on the content of nerve growth factor (NGF) in cortex, hippocampus, septum and neostriatum, and on NGF receptor (NGFRs) levels in cortical membranes. 50 mg/kg NTX treatment induced a decrease in the number of 125I-NGF high-affinity binding sites, without detectable changes in NGF levels.
Regulation (effect) of nerve growth factor in nerve associated with neurotransmitter, nerve growth factor, antagonist, hippocampus, opiate and opioid
15) Confidence 0.45 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469378 Disease Relevance 0 Pain Relevance 0.82
Previous studies have demonstrated that nerve growth factor (NGF) is released in incised tissue and contributes to hyperalgesia in incisional pain.
Regulation (contributes) of nerve growth factor in nerve associated with pain, hyperalgesia and nerve growth factor
16) Confidence 0.45 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17585224 Disease Relevance 0.39 Pain Relevance 0.57
RESULTS: NGF mRNA increased from 2 to 4 h after incision and was the same as control by postoperative day 1.
Regulation (control) of NGF mRNA
17) Confidence 0.45 Published 2007 Journal Anesthesiology Section Body Doc Link 17585224 Disease Relevance 0 Pain Relevance 0
Previous studies have demonstrated that nerve growth factor (NGF) is released in incised tissue and contributes to hyperalgesia in incisional pain.
Regulation (contributes) of NGF in nerve associated with pain, hyperalgesia and nerve growth factor
18) Confidence 0.45 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17585224 Disease Relevance 0.39 Pain Relevance 0.57
We have studied the effects of NGF on the chemosensitivity of adult rat DRG neurons over a 1-2 week period in vitro, using voltage-clamp and radioactive ion flux methods.
Regulation (effects) of NGF in neurons associated with nerve growth factor
19) Confidence 0.45 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7623122 Disease Relevance 0 Pain Relevance 0.33
Because multiple mediators are released during inflammatory processes, we examined the effect of NGF alone using viral gene transfer in vivo.
Spec (examined) Regulation (effect) of NGF associated with nerve growth factor and inflammation
20) Confidence 0.45 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.34 Pain Relevance 0.61

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