INT120014

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.03
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
blood 1
melanocytes 1
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 155 100.00 Very High Very High Very High
Inflammation 108 100.00 Very High Very High Very High
cytokine 33 99.38 Very High Very High Very High
Arthritis 102 98.08 Very High Very High Very High
rheumatoid arthritis 67 93.56 High High
cINOD 8 91.68 High High
Paracetamol 5 91.24 High High
methotrexate 29 90.84 High High
aspirin 1 86.88 High High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 111 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 80 98.08 Very High Very High Very High
Ovarian Cancer 8 98.04 Very High Very High Very High
Rheumatoid Arthritis 67 93.56 High High
Apoptosis 5 92.84 High High
Colon Cancer 1 87.92 High High
Disease 39 79.36 Quite High
Cancer 15 78.56 Quite High
Wound Healing 2 77.52 Quite High
Frailty 1 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is proposed that the major mechanism by these anti-inflammatory agents is a shared pathway dependent on the suppression of NF-kappaB activity, which may subsequently decrease transcription of growth factors, chemokines and proteases such as COX-2, VEGF, IL-8/CXCL8, MCP-1/CCL-2, MIP1alpha/CCL-3, tPA and uPA, which are shown to be elevated in ovarian carcinoma, and which play diverse roles such as inducing angiogenesis, invasion, autocrine growth loops and resistance to apoptosis.
Transcription (transcription) of CCL-3 associated with chemokine, inflammation, ovarian cancer and apoptosis
1) Confidence 0.69 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 1.00 Pain Relevance 0.72
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Transcription (Levels) of CCL3 associated with chemokine and inflammation
2) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
Constitutive transcription of CXCL10 was demonstrated in all PBMCs, while CCL3 mRNA was readily detected in control PBMCs and seven of eight PBMCs from JIA patients. mRNA for CXCL10 and CCL3 were readily detected in all SFMC samples.
Transcription (detected) of CCL3 associated with arthritis
3) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.53 Pain Relevance 0.39
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Transcription (expression) of CCL3 in blood
4) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.22 Pain Relevance 0.11
When stimulated by TLR ligands, human melanocytes can: (1) release IL-6 and IL-8 cytokines, (2) enhance chemokine (CCL2, CCL3, and CCL5) mRNA production, (3) upregulate phosphorylated I?
Transcription (production) of CCL3 in melanocytes associated with chemokine and cytokine
5) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.59 Pain Relevance 0.17

General Comments

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