INT120046

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl)
vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)
Anatomy Link Frequency
brains 2
vesicle 2
Ctsl (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 7 100.00 Very High Very High Very High
Neuropeptide 4 94.48 High High
analgesia 1 90.28 High High
Opioid 1 88.12 High High
Neurotransmitter 3 85.72 High High
Enkephalin 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cathepsin L knockout mouse brains showed extensive decreases in dynorphin A, dynorphin B, and alpha-neoendorphin that were reduced by 75%, 83%, and 90%, respectively, compared to controls.
Negative_regulation (reduced) of Localization (decreases) of Cathepsin L in brains associated with targeted disruption and dynorphin
1) Confidence 0.40 Published 2010 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19837164 Disease Relevance 0.31 Pain Relevance 0.57
In this review, evidence for secretory vesicle cathepsin L and Arg/Lys aminopeptidase as a distinct proteolytic pathway for processing the prohormone proenkephalin is presented.
Negative_regulation (presented) of Localization (secretory) of cathepsin L in vesicle
2) Confidence 0.11 Published 2004 Journal Biol. Chem. Section Abstract Doc Link 15255178 Disease Relevance 0 Pain Relevance 0.23

General Comments

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