INT12005

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Context Info
Confidence 0.57
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.49
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
brain 4
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 11 100.00 Very High Very High Very High
analgesia 5 100.00 Very High Very High Very High
Enkephalin 6 99.98 Very High Very High Very High
antagonist 8 99.90 Very High Very High Very High
noradrenaline 1 98.32 Very High Very High Very High
opiate 4 98.04 Very High Very High Very High
bradykinin 1 97.92 Very High Very High Very High
aspirin 2 97.16 Very High Very High Very High
tetrodotoxin 1 76.04 Quite High
Intracerebroventricular 2 70.88 Quite High
Disease Link Frequency Relevance Heat
Stress 10 100.00 Very High Very High Very High
Hypertension 1 100.00 Very High Very High Very High
Targeted Disruption 1 100.00 Very High Very High Very High
Hypoxia 54 93.12 High High
Pituitary Cancer 1 89.68 High High
Apoptosis 1 82.68 Quite High
INFLAMMATION 1 53.84 Quite High
Acidosis 2 5.00 Very Low Very Low Very Low
Dementia 1 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infusion of the Ang II selective antagonist, (1-Sar-8-Ile)-Ang II, blocked Ang II-induced [3H]adenosine release.
Negative_regulation (blocked) of Localization (release) of Ang II associated with adenocard and antagonist
1) Confidence 0.57 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1696651 Disease Relevance 0 Pain Relevance 0.51
Brain renin angiotensin system (RAS) in stress-induced analgesia and impaired retention.
Negative_regulation (impaired) of Localization (retention) of angiotensin system in Brain associated with stress and analgesia
2) Confidence 0.42 Published 1999 Journal Peptides Section Title Doc Link 10447091 Disease Relevance 0.65 Pain Relevance 0.48
W-7, which displays specificity for inhibition of the Ca2+/calmodulin complex below 0.2 mM, decreased angiotensin release in a dose-dependent manner.
Negative_regulation (decreased) of Localization (release) of angiotensin
3) Confidence 0.42 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1617438 Disease Relevance 0 Pain Relevance 0.16
In this context, Lochard et al. [17] reported that Ang IV can mobilize [Ca2+]i via AT1 receptors mediated by an allosteric mechanism and that AT1 receptor antagonist can block the hypertension in transgenic mice with Ang IV release in the brain.
Negative_regulation (block) of Localization (release) of Ang IV in brain associated with targeted disruption, antagonist and hypertension
4) Confidence 0.41 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.79 Pain Relevance 0.05
Release of the PGI2-like substance by angiotensin II was reduced after intravenous administration of indomethacin (2, 5, or 10 mg/kg), aspirin (100 mg/kg), aspirin (100 mg/kg), and meclofenamic acid (2 mg/kg), but was not completely eliminated by any of the above inhibitors.
Negative_regulation (reduced) of Localization (Release) of angiotensin associated with aspirin
5) Confidence 0.36 Published 1981 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6160349 Disease Relevance 0.05 Pain Relevance 0.20
It is concluded that angiotensin stimulates release of vasopressin by interaction with specific, saralasin-sensitive, receptors; leucine5-enkephalin inhibits angiotensin release of vasopressin; and an endogenously synthesized opiate ligand(s) may affect angiotensin drinking behavior.
Negative_regulation (inhibits) of Localization (release) of angiotensin associated with opiate and enkephalin
6) Confidence 0.26 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7229996 Disease Relevance 0 Pain Relevance 0.66

General Comments

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