INT120062

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 16
Disease Relevance 28.86
Pain Relevance 3.91

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unfolded protein binding (AIP) cytoplasm (AIP) signal transducer activity (AIP)
cytosol (AIP) signal transduction (AIP) nucleolus (AIP)
Anatomy Link Frequency
pseudotumor 2
MDP 2
salivary gland 2
plasma cells 1
AIP (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 492 99.98 Very High Very High Very High
Inflammation 258 99.74 Very High Very High Very High
Chronic pancreatitis 123 99.36 Very High Very High Very High
Bile 216 94.16 High High
Piles 2 83.60 Quite High
abdominal pain 13 83.24 Quite High
imagery 72 56.88 Quite High
Pain 24 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 2046 100.00 Very High Very High Very High
Disease 484 100.00 Very High Very High Very High
Porphyria 8 100.00 Very High Very High Very High
Sclerosing Cholangitis 204 99.98 Very High Very High Very High
Retroperitoneal Fibrosis 180 99.98 Very High Very High Very High
Plasma Cell Granuloma 96 99.98 Very High Very High Very High
Interstitial Nephritis 24 99.98 Very High Very High Very High
Fibrosis 348 99.82 Very High Very High Very High
Hepatocellular Cancer 5 99.80 Very High Very High Very High
Cancer 98 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immune-mediated inflammation of the MDP may be associated with AIP.
AIP Binding (associated) of in MDP associated with inflammation and pancreatitis
1) Confidence 0.42 Published 2004 Journal Pancreas Section Abstract Doc Link 15257109 Disease Relevance 0.82 Pain Relevance 0.21
Furthermore, the salivary gland lesion associated with AIP is different from that of Sjögren’s syndrome.
AIP Binding (associated) of in salivary gland associated with syndrome and pancreatitis
2) Confidence 0.40 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.13 Pain Relevance 0.03
Other reported lesions associated with AIP are pseudotumor of the hypophysis,111 immune thrombocytopenic purpura,112,113 autoimmune sensorineural hearing loss,113 hypothyroidism,114 anosmia,115 and loss of taste.115


AIP Binding (associated) of in pseudotumor associated with purpura, thyroid disease, pancreatitis, sensorineural hearing loss and loss of sense of smell
3) Confidence 0.40 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.35 Pain Relevance 0.38
Two cases (in a 64-year-old man108 and a 66-year-old man109) of tubulointerstitial nephritis associated with AIP have been reported.
AIP Binding (associated) of associated with interstitial nephritis and pancreatitis
4) Confidence 0.40 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.80 Pain Relevance 0.18
These retroperitoneal fibrotic lesions associated with AIP seem to be retroperitoneal lesions of IgG4-related systemic disease.
AIP Binding (associated) of associated with fibrosis, pancreatitis and disease
5) Confidence 0.40 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.29 Pain Relevance 0.32
Zen et al.13 reported nine cases (five men, four women; average age, 56.8 years) with an inflammatory pseudotumor of the lung that had the same pathological findings as those mentioned above; no cases were associated with AIP, and two cases were associated with sclerosing sialadenitis or lymphadenopathy.
AIP Binding (associated) of in pseudotumor associated with inflammation, lymphadenopathy, pancreatitis and sialadenitis
6) Confidence 0.40 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.35 Pain Relevance 0.42
We report 2 cases, a 56-year-old man and a 29-year-old woman, with AIP associated with immune-mediated inflammation of the main duodenal papilla (MDP).
AIP Binding (associated) of in papilla associated with inflammation and pancreatitis
7) Confidence 0.31 Published 2004 Journal Pancreas Section Abstract Doc Link 15257109 Disease Relevance 0.94 Pain Relevance 0.23
We experienced a patient with AIP showing enlargement of bilateral lacrimal glands that improved after steroid therapy.98 Thus, many cases of sclerosing sialadenitis, including Kuttner’s tumor and Mikulicz’s disease, could be salivary gland lesions of IgG4-related systemic disease.


AIP Binding (patient) of in salivary gland associated with disorders of the lacrimal system, cancer, pancreatitis, sialadenitis and disease
8) Confidence 0.31 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.13 Pain Relevance 0.13
Many new clinical aspects of AIP have been clarified during the past 10 years, and AIP has become a distinct entity recognized worldwide.4–6
AIP Binding (recognized) of associated with pancreatitis
9) Confidence 0.31 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.67 Pain Relevance 0.19
A total of ten patients (ten men; average age, 63.5 years), including our four patients, have been reported to have retroperitoneal fibrosis associated with AIP.46,100–103 In three cases, retroperitoneal fibrosis occurred 10 to 18 months before the onset of AIP.
AIP Binding (associated) of associated with fibrosis, retroperitoneal fibrosis and pancreatitis
10) Confidence 0.31 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.07 Pain Relevance 0.33
In two reported cases (a 48-year-old man65 and a 79-year-old man110) of hepatic inflammatory pseudotumor associated with AIP, the tumor showed dense infiltration of IgG4-positive plasma cells, fibrosis, and obliterative phlebitis.
AIP Binding (associated) of in plasma cells associated with fibrosis, inflammation, cv general 2 under development, cancer and pancreatitis
11) Confidence 0.30 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.02 Pain Relevance 0.44
Sclerosing cholangitis is frequently associated with AIP.
AIP Binding (associated) of associated with pancreatitis and sclerosing cholangitis
12) Confidence 0.30 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.15 Pain Relevance 0.34
Sclerosing cholangitis, sclerosing sialadenitis, and retroperitoneal fibrosis associated with AIP are different from PSC, Sjögren’s syndrome, and so-called idiopathic retroperitoneal fibrosis.
AIP Binding (associated) of associated with fibrosis, syndrome, retroperitoneal fibrosis, primary sclerosing cholangitis, pancreatitis, sialadenitis and sclerosing cholangitis
13) Confidence 0.30 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 2.95 Pain Relevance 0.25
Given the age at onset, associated diseases, pancreatographic findings, response to steroid therapy, prognosis, and IgG4-related serological and immunohistochemical data, sclerosing cholangitis associated with AIP should be differentiated from PSC.92,93 In particular, discrimination between the two diseases is necessary before making therapeutic decisions.
AIP Binding (associated) of associated with primary sclerosing cholangitis, pancreatitis, sclerosing cholangitis and disease
14) Confidence 0.30 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.84 Pain Relevance 0.28
OBJECTIVES: Although autoimmune pancreatitis (AIP) has been recently recognized as a new disease entity of chronic pancreatitis, the clinical diagnosis of the disease remains disputed.
AIP Binding (recognized) of associated with pancreatitis, disease and chronic pancreatitis
15) Confidence 0.22 Published 2006 Journal Pancreas Section Abstract Doc Link 16804408 Disease Relevance 0.66 Pain Relevance 0.10
In Northern Sweden, Lithner and Wetterberg [7] and Hardell et al.[8] have found a clear association between AIP and hepatocellular carcinoma, also confirmed by other authors [9].
AIP Spec (clear) Binding (association) of associated with porphyria and hepatocellular cancer
16) Confidence 0.18 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.71 Pain Relevance 0.08

General Comments

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