INT120067

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.13
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
Anatomy Link Frequency
cerebrospinal fluid 3
Plasma 2
NHA 2
dorsal root ganglion 2
PBMC 2
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 50 100.00 Very High Very High Very High
Multiple sclerosis 13 100.00 Very High Very High Very High
Neuritis 2 100.00 Very High Very High Very High
dorsal root ganglion 4 99.54 Very High Very High Very High
Inflammation 65 97.72 Very High Very High Very High
Morphine 6 97.60 Very High Very High Very High
Opioid 2 94.12 High High
antagonist 5 88.48 High High
narcan 2 87.52 High High
imagery 3 86.80 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 14 100.00 Very High Very High Very High
Optic Neuritis 2 100.00 Very High Very High Very High
Injury 3 99.88 Very High Very High Very High
Infection 36 99.68 Very High Very High Very High
Ganglion Cysts 5 99.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 115 99.48 Very High Very High Very High
Nociception 3 97.78 Very High Very High Very High
INFLAMMATION 68 97.72 Very High Very High Very High
Bordatella Infection 1 95.96 Very High Very High Very High
Multiple Sclerosis 2 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR.
Positive_regulation (upregulating) of Gene_expression (expression) of CCR2b in NHA associated with chemokine and morphine
1) Confidence 0.46 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.87
We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients.
Positive_regulation (concentration) of Gene_expression (expression) of CCR2 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
2) Confidence 0.30 Published 2004 Journal Eur. J. Neurol. Section Abstract Doc Link 15257681 Disease Relevance 0.85 Pain Relevance 0.58
Moreover, patients with high CCR2 levels on their PDCs (range 437–581) had a better clinical outcome (p?
Positive_regulation (high) of Gene_expression (levels) of CCR2
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.46 Pain Relevance 0
This was also illustrated for the chemokine receptors CCR5/CCR2 as well where the heterodimer was shown to couple to Gq/11, a subunit that does not interact with CCR5 homodimer or CCR2 homodimer [35].
Positive_regulation (illustrated) of Gene_expression (receptors) of CCR2 associated with chemokine
4) Confidence 0.25 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.10 Pain Relevance 0.14
They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].


Positive_regulation (activated) of Gene_expression (express) of CCR2 associated with chemokine
5) Confidence 0.23 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.21
They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].


Positive_regulation (levels) of Gene_expression (express) of CCR2 associated with chemokine
6) Confidence 0.23 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.21
Of note, HIV infection of macrophages increased their expression of the CCL2 receptor, CCR2, and CCL2 mediated transmigration of HIV-infected PBMC reduced tight junction proteins occludin, claudin-1 and ZO-1 expression in a BBB model in vitro [94].
Positive_regulation (increased) of Gene_expression (expression) of CCR2 in PBMC associated with acquired immune deficiency syndrome or hiv infection and infection
7) Confidence 0.17 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.26 Pain Relevance 0.21
Plasma monocyte chemotactic protein-1 (MCP-1) increased significantly after 14 days and 6 months and monocyte CCR2 expression increased 24 hr and 48 hr after stenting in the BMS but not the SES group.
Positive_regulation (increased) of Gene_expression (expression) of CCR2 in Plasma
8) Confidence 0.15 Published 2008 Journal Intern. Med. Section Body Doc Link 18175998 Disease Relevance 0.07 Pain Relevance 0
We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients.
Positive_regulation (concentration) of in blood Gene_expression (expression) of CCR2 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
9) Confidence 0.10 Published 2004 Journal Eur. J. Neurol. Section Abstract Doc Link 15257681 Disease Relevance 0.85 Pain Relevance 0.58
Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both MCP-1 and mRNA for its receptor CCR2.
Positive_regulation (upregulates) of in dorsal root ganglion Gene_expression (expression) of CCR2 in DRG associated with ganglion cysts, nociception, dorsal root ganglion and injury
10) Confidence 0.08 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775210 Disease Relevance 0.82 Pain Relevance 0.22

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