INT120071

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.06
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
macrophage 2
epithelium 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 12 97.96 Very High Very High Very High
cytokine 12 97.00 Very High Very High Very High
fibrosis 39 96.00 Very High Very High Very High
Inflammation 30 90.32 High High
anesthesia 4 50.64 Quite High
chemokine 16 15.12 Low Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 15 100.00 Very High Very High Very High
Injury 6 100.00 Very High Very High Very High
Pancreatitis 13 97.96 Very High Very High Very High
Respiratory Syncytial Virus 102 96.40 Very High Very High Very High
Pulmonary Fibrosis 9 96.00 Very High Very High Very High
Apoptosis 56 94.12 High High
INFLAMMATION 27 90.32 High High
Infection 23 83.04 Quite High
Fibrosis 37 82.36 Quite High
Pneumonia 5 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, cell proliferation increased in epithelium infected with Smad7 adv consistent with suppression of injury-induced upregulation of TGFbeta1 in epithelium.
Negative_regulation (suppression) of Positive_regulation (upregulation) of TGFbeta1 in epithelium associated with injury
1) Confidence 0.16 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.17 Pain Relevance 0.05
Most interestingly, only normal acini suppressed TGFbeta1 expression and accumulation specifically in normal macrophage cultures, while CP acini lost this ability.
Negative_regulation (suppressed) of Positive_regulation (accumulation) of TGFbeta1 in macrophage associated with chronic pancreatitis
2) Confidence 0.12 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18421760 Disease Relevance 1.55 Pain Relevance 1.31
1 or collagen mRNAs at 21 days and completely suppressed V2O5 induction of TGF-?
Negative_regulation (suppressed) of Positive_regulation (induction) of TGF
3) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.56 Pain Relevance 0.18
We have observed in VSMCs that preincubation with L-mevalonate, the direct HMG-CoA reductase metabolite, or GGPP, completely abolished simvastatin-induced cell death in both 10% FBS and in TGF-?
Negative_regulation (abolished) of Positive_regulation (induced) of TGF associated with death
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.77 Pain Relevance 0

General Comments

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