INT120072

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 20.87
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Anatomy Link Frequency
pancreas 3
lenses 2
bowel 2
lens epithelium 2
uterus 2
Smad7 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 85 99.56 Very High Very High Very High
Inflammation 503 99.28 Very High Very High Very High
agonist 41 98.72 Very High Very High Very High
Chronic pancreatitis 10 98.36 Very High Very High Very High
cytokine 148 98.00 Very High Very High Very High
metalloproteinase 82 97.68 Very High Very High Very High
antagonist 84 94.08 High High
anesthesia 21 93.84 High High
ischemia 1 93.84 High High
imagery 15 83.08 Quite High
Disease Link Frequency Relevance Heat
Osteolysis 10 100.00 Very High Very High Very High
Apoptosis 411 99.92 Very High Very High Very High
Inflammatory Bowel Disease 8 99.64 Very High Very High Very High
Injury 79 99.60 Very High Very High Very High
Fibrosis 88 99.56 Very High Very High Very High
Cancer 311 99.36 Very High Very High Very High
Wound Healing 6 99.30 Very High Very High Very High
Death 104 99.28 Very High Very High Very High
Targeted Disruption 60 99.00 Very High Very High Very High
Pulmonary Fibrosis 8 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to inter-implantation sites, both Smad7 and Tmem55a were also highly expressed at implantation sites.
Gene_expression (expressed) of Smad7
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
In order to examine whether the expression of Tmem55a, Timp3 and Smad7 was similar between activation of delayed implantation and implantation sites, the expression of Tmem55a, Timp3 and Smad7 was also examined in mouse uterus on day 5 of pregnancy.
Spec (examined) Gene_expression (expression) of Smad7 in uterus
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
In order to examine whether the expression of Tmem55a, Timp3 and Smad7 was similar between activation of delayed implantation and implantation sites, the expression of Tmem55a, Timp3 and Smad7 was also examined in mouse uterus on day 5 of pregnancy.
Gene_expression (expression) of Smad7 in uterus
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice.
Gene_expression (transfer) of Smad7 in lens epithelium associated with injury
4) Confidence 0.73 Published 2004 Journal Lab. Invest. Section Title Doc Link 15258599 Disease Relevance 0.27 Pain Relevance 0.08
A mixture of recombinant adenovirus carrying CAG promoter-driven Cre (Cre adv) and mouse Smad7 complementary DNA (Smad7 adv) was administered to induce Smad7 expression, while control lenses were treated with Cre adv alone.
Gene_expression (expression) of Smad7 in lenses
5) Confidence 0.73 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.25 Pain Relevance 0.09
We examined the effect of adenovirus-mediated transient expression of Smad7, an inhibitory Smad in TGFbeta/activin signaling, on injury-induced epithelial-mesenchymal transition (EMT) of lens epithelium in mice.
Gene_expression (expression) of Smad7 in lens epithelium associated with injury
6) Confidence 0.73 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.25 Pain Relevance 0.07
We conclude that gene transfer of Smad7 in mice prevents injury-induced EMT of lens epithelial cells and sealing of the capsular break with fibrous tissue.
Gene_expression (transfer) of Smad7 in lens associated with injury
7) Confidence 0.73 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.27 Pain Relevance 0
During healing, marked expression of Smad7 was observed in lens epithelial cells in the Smad7 adv group with loss of nuclear translocation of Smads2/3, while little Smad7 and abundant nuclear Smads2/3 were seen in cells in the Cre adv group.
Gene_expression (expression) of Smad7 in epithelial cells
8) Confidence 0.73 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.23 Pain Relevance 0.08
Klf9, Gatm and Dnajb9 were predicted to be the target genes of unedited let-7a, whereas Tmem55a, Timp3 and Smad7 were predicted to be target genes of edited let-7a-5C.
Gene_expression (predicted) of Smad7
9) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7.
Gene_expression (expression) of Smad7 in pancreas associated with fibrosis
10) Confidence 0.59 Published 2009 Journal Biochim. Biophys. Acta Section Title Doc Link 19015026 Disease Relevance 1.16 Pain Relevance 0.43
Smad7 expression in the pancreas was able to significantly inhibit cerulein-induced pancreatic fibrosis.
Gene_expression (expression) of Smad7 in pancreas associated with fibrosis
11) Confidence 0.59 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19015026 Disease Relevance 1.14 Pain Relevance 0.45
Smad7, an intracellular inhibitory protein that antagonizes TGF-beta signaling, was specifically expressed in the pancreas using a transgenic mouse model.
Gene_expression (expressed) of Smad7 in pancreas associated with targeted disruption
12) Confidence 0.59 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19015026 Disease Relevance 1.18 Pain Relevance 0.46
In our study, Smad7 expression is mainly localized in the subluminal stromal cells at implantation sites under activation, suggesting that Smad7 and MMP-2 should be co-localized at subluminal stromal cells at implantation sites.
Gene_expression (expression) of Smad7 in stromal cells
13) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0.05
The expression of Tmem55a, Timp3 and Smad7 was determined by qRT-PCR.
Spec (determined) Gene_expression (expression) of Smad7
14) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
signaling, has been shown to attenuate bleomycin-induced lung fibrosis in mice receiving intratracheal injection of recombinant adenovirus overexpressing Smad7 [42].
Gene_expression (overexpressing) of Smad7 in lung associated with fibrosis and pulmonary fibrosis
15) Confidence 0.53 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.83 Pain Relevance 0.22
The addition of TSA to cultures upregulated the expression of Smad7 and TGIF in a dose-dependent manner (Figure 2A).
Gene_expression (expression) of Smad7
16) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.03
compared to the expression levels of THBS1, vWF, MADH7, and Sec Pro.
Gene_expression (expression) of MADH7
17) Confidence 0.46 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0
In the present study, we monitored the expression of RGS1, CC3, THBS1, vWF, MADH7, and a novel gene encoding a secreted protein in irradiated Jurkat, TK6, HeLa, and HFL1 cells.
Gene_expression (expression) of MADH7 in HFL1
18) Confidence 0.46 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
signaling by knockdown of Smad4 [11], [12], overexpression of the inhibitory Smad7 [13], or treatment with pharmacologic inhibitors, such as SD-208 [14], an ATP-competitive inhibitor of the T?
Gene_expression (overexpression) of Smad7
19) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.20 Pain Relevance 0.04
Moreover, the blockade of Smad activation by Smad7 overexpression diminished statin-induced VSMC apoptosis.
Gene_expression (overexpression) of Smad7 associated with apoptosis
20) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 1.37 Pain Relevance 0.06

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