INT120073

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 23.45
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Itk) kinase activity (Itk) cytoplasm (Itk)
Anatomy Link Frequency
4T1 3
epithelial cells 3
stem 3
endometrium 2
stem cells 2
Itk (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 84 99.08 Very High Very High Very High
antagonist 87 91.80 High High
cytokine 18 79.84 Quite High
Inflammation 81 78.80 Quite High
fibrosis 66 77.56 Quite High
anesthesia 6 45.28 Quite Low
COX-2 inhibitor 1 31.24 Quite Low
cINOD 5 12.52 Low Low
imagery 99 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 32 99.98 Very High Very High Very High
Non-small-cell Lung Cancer 24 99.84 Very High Very High Very High
Carcinoma 112 99.66 Very High Very High Very High
Breast Cancer 933 99.56 Very High Very High Very High
Targeted Disruption 66 99.50 Very High Very High Very High
Cancer 2265 99.44 Very High Very High Very High
Recurrence 57 99.24 Very High Very High Very High
Dysmenorrhea 84 99.08 Very High Very High Very High
Metastasis 1199 97.96 Very High Very High Very High
Disease 113 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that oestrogen-induced EMT is critical in the pathogenesis of adenomyosis.
Positive_regulation (induced) of EMT associated with dismenorea
1) Confidence 0.44 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.77 Pain Relevance 0.68
Epithelial-mesenchymal transition (EMT) endows cells with migratory and invasive properties and can be induced by oestrogen.
Positive_regulation (induced) of EMT
2) Confidence 0.32 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.66 Pain Relevance 0.56
In adenomyosis, the serum E2 level was negatively correlated with E-cadherin expression in the epithelial components of the eutopic endometrium and adenomyotic lesions, suggesting the involvement of oestrogen-induced EMT in endometrial cells.
Positive_regulation (induced) of EMT in endometrium associated with dismenorea
3) Confidence 0.32 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 1.02 Pain Relevance 0.91
Collectively, these data highlight the crucial role of oestrogen-induced EMT in the development of adenomyosis and suggest that raloxifene may be a potential therapeutic agent for adenomyosis patients.
Positive_regulation (induced) of EMT associated with dismenorea
4) Confidence 0.32 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.79 Pain Relevance 0.70
To determine the role of oestrogen-induced EMT in the implantation of ectopic endometrium, we xenotransplanted eutopic endometrium or adenomyotic lesions from adenomyosis patients into ovariectomized SCID mice.
Positive_regulation (induced) of EMT in endometrium associated with severe combined immunodeficiency and dismenorea
5) Confidence 0.32 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.88 Pain Relevance 0.93
In oestrogen receptor-positive Ishikawa endometrial epithelial cells, oestrogen induced a morphological change to a fibroblast-like phenotype, a shift from epithelial marker expression to mesenchymal marker expression, increased migration and invasion, and up-regulation of the EMT regulator Slug.
Positive_regulation (up-regulation) of EMT in fibroblast
6) Confidence 0.30 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.88 Pain Relevance 0.92
and doxorubicin in inducing EMT in murine breast cancer cells in vitro.


Positive_regulation (inducing) of EMT associated with breast cancer
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.16 Pain Relevance 0
We have used this model to study whether doxorubicin induced EMT can promote the formation of mammospheres which represents self-renewing stem/early progenitor cells.
Positive_regulation (induced) of EMT in stem
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.35 Pain Relevance 0
signaling, doxorubicin has the ability to induce EMT and generate tumor cells with stem cell phenotypes.
Positive_regulation (induce) of EMT in stem cell associated with cancer
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.77 Pain Relevance 0
The fact that EMT can generate stem-like cancer cells [26] suggests that therapeutic-resistant cancer stem cells may be the result of either the transformation of normal stem cells or via the induction of EMT in more differentiated cancer cells.
Positive_regulation (induction) of EMT in stem cells associated with cancer
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.97 Pain Relevance 0
signaling, which has the potential to induce EMT and to generate drug resistant stem-like cancer cells.
Positive_regulation (induce) of EMT in stem associated with cancer
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.81 Pain Relevance 0
Induction of EMT has been shown to promote mammosphere formation in primary human mammary epithelial cells after prolonged treatment with TGF?
Positive_regulation (Induction) of EMT in epithelial cells
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.48 Pain Relevance 0
and surprisingly also doxorubicin can induce EMT as evidenced by the mesenchymal morphology, reorganization of the actin cytoskeleton and nuclear localization of the embryonic transcription factor Snail.
Positive_regulation (induce) of EMT
13) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.97 Pain Relevance 0
We also observed an increased nuclear translocation of the transcription factor Snail, which is known to promote EMT [36] after the treatment of the 4T1 cells with TGF?
Positive_regulation (promote) of EMT in 4T1
14) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.11 Pain Relevance 0
-induced EMT may result in the maintenance and formation of stem-like breast cancer cells.
Positive_regulation (induced) of EMT in stem associated with breast cancer
15) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.79 Pain Relevance 0
Doxorubicin induced EMT, promoted invasion and enhanced generation of cells with stem cell phenotype in murine 4T1 breast cancer cell line in vitro, which were significantly inhibited by T?
Positive_regulation (induced) of EMT in 4T1 associated with breast cancer
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.10 Pain Relevance 0.04
is a potent inducer of EMT and has been shown to promote tumor progression in various breast cancer cell and animal models.


Positive_regulation (inducer) of EMT associated with cancer and breast cancer
17) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2860989 Disease Relevance 0.83 Pain Relevance 0
Induction of EMT by TGF?
Positive_regulation (Induction) of EMT
18) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.88 Pain Relevance 0
Recent studies suggested that induction of epithelial-mesenchymal transition (EMT) might confer both metastatic and self-renewal properties to breast tumor cells resulting in drug resistance and tumor recurrence.
Positive_regulation (induction) of EMT associated with cancer, breast cancer and recurrence
19) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2860989 Disease Relevance 0.66 Pain Relevance 0
It induces EMT not only during embryonic development but also during tumor progression in vivo [34].
Positive_regulation (induces) of EMT associated with cancer
20) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.53 Pain Relevance 0

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