INT120074

Context Info Confidence 0.58 First Reported 2004 Last Reported 2007 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.05 Pain Relevance 0.50

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7) intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)

Anatomy Link Frequency lens epithelium 2 Smad7 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 100 99.08 anesthesia 1 74.08 cINOD 2 59.12 cytokine 25 55.52 corticosteroid 5 54.72 agonist 1 48.96 metalloproteinase 19 45.84 chemokine 20 5.00 antagonist 19 5.00 Bioavailability 11 5.00

Disease Link Frequency Relevance Heat Pulmonary Disease 144 100.00 INFLAMMATION 106 99.08 Injury 13 97.84 Emphysema 22 97.04 Nicotine Addiction 49 71.52 Stress 23 64.52 Asthma 12 56.16 Inflammatory Bowel Disease 2 51.56 Wound Healing 1 42.24 Disease 13 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We examined the effect of adenovirus-mediated transient expression of Smad7, an inhibitory Smad in TGFbeta/activin signaling, on injury-induced epithelial-mesenchymal transition (EMT) of lens epithelium in mice.

Spec (examined) Regulation (effect) of Gene_expression (expression) of Smad7 in lens epithelium associated with injury

1) Confidence 0.58 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.25 Pain Relevance 0.07

1 and Smad7 expression in pulmonary cells of patients with COPD seems to be delicate and may affect tissue remodeling and inflammation differently depending on the COPD phenotype.

Spec (may) Regulation (affect) of Gene_expression (expression) of Smad7 associated with pulmonary disease and inflammation

2) Confidence 0.19 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.80 Pain Relevance 0.43

General Comments

This test has worked.