INT120074

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.05
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Anatomy Link Frequency
lens epithelium 2
Smad7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 100 99.08 Very High Very High Very High
anesthesia 1 74.08 Quite High
cINOD 2 59.12 Quite High
cytokine 25 55.52 Quite High
corticosteroid 5 54.72 Quite High
agonist 1 48.96 Quite Low
metalloproteinase 19 45.84 Quite Low
chemokine 20 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 144 100.00 Very High Very High Very High
INFLAMMATION 106 99.08 Very High Very High Very High
Injury 13 97.84 Very High Very High Very High
Emphysema 22 97.04 Very High Very High Very High
Nicotine Addiction 49 71.52 Quite High
Stress 23 64.52 Quite High
Asthma 12 56.16 Quite High
Inflammatory Bowel Disease 2 51.56 Quite High
Wound Healing 1 42.24 Quite Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of adenovirus-mediated transient expression of Smad7, an inhibitory Smad in TGFbeta/activin signaling, on injury-induced epithelial-mesenchymal transition (EMT) of lens epithelium in mice.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Smad7 in lens epithelium associated with injury
1) Confidence 0.58 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.25 Pain Relevance 0.07
1 and Smad7 expression in pulmonary cells of patients with COPD seems to be delicate and may affect tissue remodeling and inflammation differently depending on the COPD phenotype.
Spec (may) Regulation (affect) of Gene_expression (expression) of Smad7 associated with pulmonary disease and inflammation
2) Confidence 0.19 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.80 Pain Relevance 0.43

General Comments

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