INT120076

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.33
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Anatomy Link Frequency
lenses 4
bowel 4
lens epithelium 2
lung 2
Smad7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 385 99.46 Very High Very High Very High
fibrosis 32 98.62 Very High Very High Very High
cytokine 102 98.00 Very High Very High Very High
metalloproteinase 57 97.68 Very High Very High Very High
anesthesia 11 94.12 High High
antagonist 59 94.08 High High
chemokine 64 81.72 Quite High
agonist 13 55.44 Quite High
imagery 6 26.12 Quite Low
Bioavailability 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 293 99.92 Very High Very High Very High
Inflammatory Bowel Disease 6 99.84 Very High Very High Very High
Injury 58 99.60 Very High Very High Very High
Wound Healing 4 99.30 Very High Very High Very High
Death 84 99.28 Very High Very High Very High
Targeted Disruption 44 98.96 Very High Very High Very High
Pulmonary Fibrosis 8 98.62 Very High Very High Very High
INFLAMMATION 411 97.32 Very High Very High Very High
Metastasis 109 96.28 Very High Very High Very High
Soft Tissue Injuries 1 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice.
Positive_regulation (transfer) of Gene_expression (transfer) of Smad7 in lens epithelium associated with injury
1) Confidence 0.65 Published 2004 Journal Lab. Invest. Section Title Doc Link 15258599 Disease Relevance 0.27 Pain Relevance 0.08
A mixture of recombinant adenovirus carrying CAG promoter-driven Cre (Cre adv) and mouse Smad7 complementary DNA (Smad7 adv) was administered to induce Smad7 expression, while control lenses were treated with Cre adv alone.
Positive_regulation (induce) of Gene_expression (expression) of Smad7 in lenses
2) Confidence 0.65 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.25 Pain Relevance 0.09
We conclude that gene transfer of Smad7 in mice prevents injury-induced EMT of lens epithelial cells and sealing of the capsular break with fibrous tissue.
Positive_regulation (transfer) of Gene_expression (transfer) of Smad7 in lens associated with injury
3) Confidence 0.65 Published 2004 Journal Lab. Invest. Section Abstract Doc Link 15258599 Disease Relevance 0.27 Pain Relevance 0
signaling, has been shown to attenuate bleomycin-induced lung fibrosis in mice receiving intratracheal injection of recombinant adenovirus overexpressing Smad7 [42].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Smad7 in lung associated with fibrosis and pulmonary fibrosis
4) Confidence 0.48 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.83 Pain Relevance 0.22
Moreover, the blockade of Smad activation by Smad7 overexpression diminished statin-induced VSMC apoptosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad7 associated with apoptosis
5) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 1.37 Pain Relevance 0.06
signaling by knockdown of Smad4 [11], [12], overexpression of the inhibitory Smad7 [13], or treatment with pharmacologic inhibitors, such as SD-208 [14], an ATP-competitive inhibitor of the T?
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad7
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.20 Pain Relevance 0.04
The addition of TSA to cultures upregulated the expression of Smad7 and TGIF in a dose-dependent manner (Figure 2A).
Positive_regulation (upregulated) of Gene_expression (expression) of Smad7
7) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.03
In vivo wound healing study with mice demonstrated that overexpression of Smad7 inhibits TGF?
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad7 associated with wound healing
8) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.28 Pain Relevance 0.24
The most prominent gene induction was seen for MADH7,
Positive_regulation (induction) of Gene_expression (seen) of MADH7
9) Confidence 0.29 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0
The expression of MADH7 was induced in all the cell types examined.
Positive_regulation (induced) of Gene_expression (expression) of MADH7
10) Confidence 0.27 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
Cotransfection with DN-RhoA and Smad7 markedly suppressed DN-RhoA-induced cell death (Figure 4a and b).


Positive_regulation (Cotransfection) of Gene_expression (Cotransfection) of Smad7 associated with death
11) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.84 Pain Relevance 0
Smad7 overexpression decreased statin-induced cell death compared to cells transfected with an empty vector (Figure 2d) - suggesting that the Smad pathway drives statin-induced cell death.


Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad7 associated with death
12) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.83 Pain Relevance 0
To evaluate the involvement of the Smad pathway in statin-induced cell death in 10% FBS, cells were transiently transfected with a Smad7 overexpressing vector that inhibits TGF-?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Smad7 associated with death
13) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.78 Pain Relevance 0
To evaluate the involvement of the Smad pathway in statin-induced cell death in 10% FBS, cells were transiently transfected with a Smad7 overexpressing vector that inhibits TGF-?
Positive_regulation (transfected) of Gene_expression (transfected) of Smad7 associated with death
14) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.78 Pain Relevance 0
Reducing overexpression of Smad7 in patients with inflammatory bowel disease (IBD) using antisense Smad7 oligonucleotides caused a decreased production of proinflammatory cytokines IFN?
Positive_regulation (overexpression) of Gene_expression (overexpression) of Smad7 in bowel associated with inflammatory bowel disease, inflammation and cytokine
15) Confidence 0.21 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.27 Pain Relevance 0.23
Reducing overexpression of Smad7 in patients with inflammatory bowel disease (IBD) using antisense Smad7 oligonucleotides caused a decreased production of proinflammatory cytokines IFN?
Positive_regulation (antisense) of Gene_expression (oligonucleotides) of Smad7 in bowel associated with inflammatory bowel disease, inflammation and cytokine
16) Confidence 0.21 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.29 Pain Relevance 0.26

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