INT120085

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.61
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
periosteum 2
bone marrow 2
Bmp4 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 52 72.88 Quite High
rheumatoid arthritis 35 72.88 Quite High
Osteoarthritis 37 72.32 Quite High
chemokine 2 40.04 Quite Low
cytokine 12 39.56 Quite Low
Inflammation 34 5.00 Very Low Very Low Very Low
Arthritis 17 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 8 96.96 Very High Very High Very High
Congenital Anomalies 3 92.28 High High
Mucositis 42 79.80 Quite High
Rheumatoid Arthritis 35 72.88 Quite High
Osteoarthritis 37 72.32 Quite High
Osteophyte 5 67.48 Quite High
Arthritis 25 50.00 Quite Low
Apoptosis 30 26.68 Quite Low
Frailty 21 15.92 Low Low
INFLAMMATION 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At day 2, this decrease in BMP4 expression level progressed and was almost significant (P=0.05) in comparison to the control level.
Negative_regulation (decrease) of Gene_expression (expression) of BMP4
1) Confidence 0.55 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.09 Pain Relevance 0.04
BMP4 expression decreased almost significant at day 2, which correlated well with an increasing degree of morphological damage, increased proliferation, and loss of epithelial differentiation as measured by the decreased SI and likely TFF3 expression.
Negative_regulation (decreased) of Gene_expression (expression) of BMP4
2) Confidence 0.55 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.08 Pain Relevance 0.06
Here we show that there indeed might be a close relationship between BMP and Wnt pathways, because at day 1 when BMP4 expression is decreased, expression of TCF4, a Wnt effector, increased significantly, which correlated well with increased proliferation and inhibited epithelial differentiation.
Negative_regulation (decreased) of Gene_expression (expression) of BMP4
3) Confidence 0.48 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.06 Pain Relevance 0
In addition, production of growth factors (TGFbeta, BMP-2 and BMP-4) in the lining was largely prevented but production of these growth factors in deeper layers of the synovium and the periosteum did not differ from controls.
Negative_regulation (prevented) of Gene_expression (production) of BMP-4 in periosteum
4) Confidence 0.11 Published 2004 Journal Osteoarthr. Cartil. Section Body Doc Link 15262242 Disease Relevance 0.14 Pain Relevance 0
type I receptor and reduced expression of BMP-2, BMP-4, and BMP-6 when compared with bone marrow MSCs, supplementation with BMP-6 and TGF-?
Negative_regulation (reduced) of Gene_expression (expression) of BMP-4 in bone marrow
5) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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