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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.34
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp2) extracellular space (Bmp2) growth (Bmp2)
extracellular region (Bmp2) embryo development (Bmp2) protein complex (Bmp2)
Anatomy Link Frequency
canal 1
periosteum 1
Bmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 21 99.68 Very High Very High Very High
cytokine 20 93.40 High High
Inflammation 79 93.00 High High
antagonist 8 85.28 High High
Pain 2 78.36 Quite High
chemokine 7 78.32 Quite High
cINOD 26 59.44 Quite High
Osteoarthritis 4 50.00 Quite Low
Inflammatory response 11 35.76 Quite Low
fibrosis 3 26.48 Quite Low
Disease Link Frequency Relevance Heat
Stomach Cancer 58 99.68 Very High Very High Very High
Neurodegenerative Disease 128 97.24 Very High Very High Very High
Malignant Neoplastic Disease 10 96.96 Very High Very High Very High
Apoptosis 2 95.12 Very High Very High Very High
INFLAMMATION 94 93.00 High High
Cancer 66 91.64 High High
Metastasis 7 90.96 High High
Gliosis 23 89.28 High High
Pain 2 78.36 Quite High
Osteoarthritis 4 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2).
Gene_expression (use) of bone morphogenetic protein-2 in canal
1) Confidence 0.27 Published 2008 Journal Spine J Section Title Doc Link 18037352 Disease Relevance 0.08 Pain Relevance 0.08
superfamily ligands such as BMP1, BMP2, BMP5, and BMP7 were also expressed in the CNS after KA-induced neurodegeneration (supporting information Table 1).
Gene_expression (expressed) of BMP2 associated with central nervous system
2) Confidence 0.21 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.90 Pain Relevance 0.31
In addition, production of growth factors (TGFbeta, BMP-2 and BMP-4) in the lining was largely prevented but production of these growth factors in deeper layers of the synovium and the periosteum did not differ from controls.
Gene_expression (production) of BMP-2 in periosteum
3) Confidence 0.20 Published 2004 Journal Osteoarthr. Cartil. Section Body Doc Link 15262242 Disease Relevance 0.14 Pain Relevance 0
and BMP2, is overexpressed in the gastric cancers relative to the paired normal [32].
Gene_expression (overexpressed) of BMP2 associated with stomach cancer
4) Confidence 0.13 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.22 Pain Relevance 0.04
Statin can induce the gene expression of bone morphogenetic protein-2.
Gene_expression (expression) of bone morphogenetic protein-2
5) Confidence 0.06 Published 2008 Journal Chin Med Section Abstract Doc Link PMC2294127 Disease Relevance 0 Pain Relevance 0

General Comments

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