INT120089

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 17
Disease Relevance 10.36
Pain Relevance 5.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
brain 1
PNS 1
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 221 100.00 Very High Very High Very High
Neuritis 42 99.92 Very High Very High Very High
Sciatic nerve 8 99.60 Very High Very High Very High
Inflammation 84 99.30 Very High Very High Very High
antagonist 217 97.72 Very High Very High Very High
Peripheral nervous system 16 97.68 Very High Very High Very High
cytokine 13 97.00 Very High Very High Very High
Multiple sclerosis 60 92.88 High High
agonist 11 58.56 Quite High
potassium channel 22 27.92 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 36 99.92 Very High Very High Very High
Infection 109 99.48 Very High Very High Very High
INFLAMMATION 87 99.30 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 627 99.28 Very High Very High Very High
Recurrence 16 97.12 Very High Very High Very High
Severe Combined Immunodeficiency 11 97.04 Very High Very High Very High
Demyelinating Disease 82 93.60 High High
Syndrome 22 91.64 High High
Opportunistic Infections 11 82.88 Quite High
Hepatotoxicity 11 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR5 deficiency does not prevent P0 peptide 180-199 immunized mice from experimental autoimmune neuritis.
Negative_regulation (deficiency) of CCR5 associated with chemokine, experimental autoimmune neuritis and neuritis
1) Confidence 0.58 Published 2004 Journal Neurobiol. Dis. Section Title Doc Link 15262275 Disease Relevance 1.19 Pain Relevance 1.22
Future of CCR5 inhibition
Negative_regulation (inhibition) of CCR5
2) Confidence 0.55 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0 Pain Relevance 0.12
Removal of CCR5 from cell surfaces
Negative_regulation (Removal) of CCR5
3) Confidence 0.48 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.41 Pain Relevance 0.15
Increased MIP-1beta and IP-10 in sciatic nerves may compensate the CCR5 deficiency and contribute to inflammatory cells infiltrating to the PNS.
Negative_regulation (deficiency) of CCR5 in PNS associated with peripheral nervous system, inflammation and sciatic nerve
4) Confidence 0.43 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15262275 Disease Relevance 1.11 Pain Relevance 1.11
To explore the role of CC chemokine receptor 5 (CCR5) in the inflammatory process of EAN, we induced EAN in CCR5-deficient (CCR5(-/-)) mice with P0 protein peptide 180-199.
Negative_regulation (deficient) of CCR5 associated with chemokine, inflammation and neuritis
5) Confidence 0.43 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15262275 Disease Relevance 1.23 Pain Relevance 1.16
To explore the role of CC chemokine receptor 5 (CCR5) in the inflammatory process of EAN, we induced EAN in CCR5-deficient (CCR5(-/-)) mice with P0 protein peptide 180-199.
Negative_regulation (deficient) of CCR5 associated with chemokine, inflammation and neuritis
6) Confidence 0.43 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15262275 Disease Relevance 1.23 Pain Relevance 1.16
Their lead candidate PF-232798 is an imidazopiperidine CCR5 inhibitor that was identified in a medicinal chemistry synthetic campaign guided by a biological screening cascade after the identification of the triazole inhibitor maraviroc (Dorr et al 2008).
Negative_regulation (inhibitor) of CCR5
7) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.36 Pain Relevance 0.04
Besides maraviroc, several promising strategies for CCR5 blockade are currently being employed in the development of CCR5 antagonists.
Negative_regulation (blockade) of CCR5 associated with antagonist
8) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0 Pain Relevance 0.13
This review summarizes the recent literature on the use of maraviroc in the treatment of HIV infection as well as the future of CCR5 inhibitors.


Negative_regulation (inhibitors) of CCR5 associated with acquired immune deficiency syndrome or hiv infection and infection
9) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.73 Pain Relevance 0.09
It heralds a new class of ARV drugs, namely CCR5 inhibitors, with several other second-generation candidates following in the clinical pipeline.
Negative_regulation (inhibitors) of CCR5
10) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 1.20 Pain Relevance 0
Genetic disruption of CCR5 imparted robust, stable, and heritable protection against HIV-1 in a NOG/SCID mouse model of infection (Perez et al 2008).
Negative_regulation (disruption) of CCR5 associated with severe combined immunodeficiency, acquired immune deficiency syndrome or hiv infection and infection
11) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.89 Pain Relevance 0.03
Amongst these candidates the drugs that are farthest along in clinical development include the fusion inhibitors and the CCR5 coreceptor inhibitors.
Negative_regulation (inhibitors) of CCR5
12) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.05 Pain Relevance 0.06
However, in the case of CCR5 inhibitors the percentage of patients harboring R5 only using viruses is much higher in treatment-naïve patients (about 80% in naïve versus 48%–60% in experienced patients), arguing for a more favorable target population in these rather than more experienced subjects.
Negative_regulation (inhibitors) of CCR5
13) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.07 Pain Relevance 0.04
Following the successful licensing of maraviroc, Pfizer is developing a second-generation CCR5 inhibitor.
Negative_regulation (inhibitor) of CCR5
14) Confidence 0.41 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.36 Pain Relevance 0.04
Resistance to CCR5 inhibitors could also result from viruses that bind coreceptor with higher affinity (and can therefore compete out bound drug), or are able to enter by scavenging low levels of coreceptor either due to higher affinity or a greater proclivity for Env protein triggering.
Negative_regulation (inhibitors) of CCR5
15) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.20 Pain Relevance 0
Also the absence of CCR5 receptor in Plasmodium berghei ANKA-infected mouse brain resulted in a reduced Th1 cytokine production [9].
Negative_regulation (absence) of CCR5 receptor in brain associated with cytokine
16) Confidence 0.35 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.59 Pain Relevance 0.31
The observation regarding the association of CCR5 with RRMS is consistent with a previous study revealing that patients with the defective CCR5 receptor (CCR5 ?
Negative_regulation (defective) of CCR5 receptor
17) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.75 Pain Relevance 0.28

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