INT120090

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.94
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL4) extracellular space (CCL4) extracellular region (CCL4)
cell adhesion (CCL4) cell-cell signaling (CCL4)
Anatomy Link Frequency
monocytes 4
plasma 2
sciatic nerves 2
microglia 2
CCL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 100.00 Very High Very High Very High
chemokine 34 100.00 Very High Very High Very High
Sciatic nerve 2 99.84 Very High Very High Very High
Inflammation 52 99.20 Very High Very High Very High
Neuritis 10 94.48 High High
Inflammatory response 6 89.60 High High
cINOD 2 85.64 High High
Inflammatory stimuli 1 85.20 High High
Peripheral nervous system 4 79.40 Quite High
Central nervous system 15 58.24 Quite High
Disease Link Frequency Relevance Heat
Disease 29 99.48 Very High Very High Very High
INFLAMMATION 66 99.20 Very High Very High Very High
Critical Illness 37 95.36 Very High Very High Very High
Experimental Autoimmune Neuritis 9 94.48 High High
Alzheimer's Dementia 4 91.60 High High
Neurodegenerative Disease 10 91.40 High High
Apoptosis 56 78.16 Quite High
Syndrome 1 76.92 Quite High
Influenza Virus Infection 15 75.00 Quite High
Demyelinating Disease 1 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, increased IP-10 and MIP-1beta production in sciatic nerves were seen in CCR5(-/-) mice.
Positive_regulation (increased) of Gene_expression (production) of MIP-1beta in sciatic nerves associated with sciatic nerve
1) Confidence 0.49 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15262275 Disease Relevance 1.12 Pain Relevance 1.18
Our previous studies showed that interaction of Abeta1-40 or fibrilar Abeta1-42 caused activation of nuclear transcription factor, early growth response-1 (Egr-1), which resulted in increased expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in monocytes.
Positive_regulation (resulted) of Gene_expression (expression) of MIP-1beta in monocytes associated with chemokine and cytokine
2) Confidence 0.49 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.87 Pain Relevance 0.43
Our previous studies showed that interaction of Abeta1-40 or fibrilar Abeta1-42 caused activation of nuclear transcription factor, early growth response-1 (Egr-1), which resulted in increased expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in monocytes.
Positive_regulation (increased) of Gene_expression (expression) of MIP-1beta in monocytes associated with chemokine and cytokine
3) Confidence 0.49 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.86 Pain Relevance 0.43
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Positive_regulation (increased) of Gene_expression (levels) of CCL4 in plasma associated with disease
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Positive_regulation (contributes) of Gene_expression (expression) of CCL4 in microglia associated with chemokine and inflammation
5) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.49 Pain Relevance 0.21

General Comments

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