INT120106

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.25
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
IVD 1
Mmp13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 116 100.00 Very High Very High Very High
agonist 57 97.76 Very High Very High Very High
Osteoarthritis 12 95.32 Very High Very High Very High
fibrosis 33 91.84 High High
Potency 16 90.08 High High
Inflammation 11 85.72 High High
Pain 5 84.52 Quite High
Arthritis 4 81.12 Quite High
Chronic low back pain 1 70.60 Quite High
Angina 1 55.24 Quite High
Disease Link Frequency Relevance Heat
Syndrome 2 98.48 Very High Very High Very High
Osteoarthritis 17 95.32 Very High Very High Very High
Disease 7 94.82 High High
Fibrosis 24 91.84 High High
Increased Venous Pressure Under Development 1 88.68 High High
INFLAMMATION 12 85.72 High High
Atherosclerotic Plaque 6 84.44 Quite High
Neck Pain 1 83.08 Quite High
Intervertebral Disk Degeneration 1 75.00 Quite High
Low Back Pain 1 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, highly selective inhibition of MMP13 in patients may overcome the major safety and efficacy challenges that have limited previously tested non-selective MMP inhibitors.
Negative_regulation (inhibition) of MMP13
1) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17623656 Disease Relevance 0.40 Pain Relevance 0.22
In our efforts to develop a disease-modifying osteoarthritis drug, we have discovered MMP13 inhibitors that differ greatly from previous MMP inhibitors; they do not bind to the catalytic zinc ion, they are noncompetitive with respect to substrate binding, and they show extreme selectivity for inhibiting MMP13.
Negative_regulation (inhibiting) of MMP13 associated with disease and osteoarthritis
2) Confidence 0.51 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17623656 Disease Relevance 0.43 Pain Relevance 0.24
Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months.
Negative_regulation (decreased) of MMP13 in IVD associated with metalloproteinase
3) Confidence 0.41 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20472983 Disease Relevance 0.23 Pain Relevance 0.20
TAA slightly increased MT1-MMP and decreased MMP-13 levels, but not significantly.
Negative_regulation (decreased) of MMP-13
4) Confidence 0.17 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.44 Pain Relevance 0.38
1 decreased global MMP and MMP-13 activities by 66% and by 19%, respectively, (Figures 4(a) and 4(b)), while increasing TIMP-1 levels by 75% (Figure 4(c)).
Negative_regulation (decreased) of MMP-13 associated with metalloproteinase
5) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.64
On the basis of these previous studies, we discuss the need for studies on the effect of statin treatment on the serum levels of MMP-13 and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels in hypercholesterolemic patients.
Negative_regulation (inhibitor) of MMP-13 associated with metalloproteinase
6) Confidence 0.05 Published 2008 Journal J Cardiovasc Med (Hagerstown) Section Abstract Doc Link 19001938 Disease Relevance 0.75 Pain Relevance 0.40
RESULTS: There was a significant increase in collagenase-3 (MMP-13) mRNA levels, a decrease in stromelysin-1 (MMP-3) mRNA levels, and a decrease in tissue inhibitor of metalloproteinase-2, -3, and -4 mRNA levels.
Negative_regulation (decrease) of collagenase-3
7) Confidence 0.02 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0
RESULTS: There was a significant increase in collagenase-3 (MMP-13) mRNA levels, a decrease in stromelysin-1 (MMP-3) mRNA levels, and a decrease in tissue inhibitor of metalloproteinase-2, -3, and -4 mRNA levels.
Negative_regulation (decrease) of collagenase-3
8) Confidence 0.02 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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